Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039176282> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2039176282 endingPage "352" @default.
- W2039176282 startingPage "348" @default.
- W2039176282 abstract "Combined determination of urokinase-type plasminogen activator (uPA) and its inhibitor, activator inhibitor type 1 (PAI-1), supports risk-adapted individualized therapy concepts, particularly in node-negative breast cancer. The prognostic impact of both factors in primary breast cancer was substantiated by a pooled analysis of > 8000 patients with breast cancer and a multicenter prospective randomized therapy trial in node-negative breast cancer; findings achieved the highest level of evidence for tumor biomarkers. Patients with node-negative breast cancer with low antigen levels of uPA and PAI-1 in their primary tumor tissue have a very good prognosis and therefore may be spared the burden of adjuvant chemotherapy, whereas those with elevated uPA/PAI-1 antigen levels carry an increased risk of disease recurrence. Recent retrospective analysis of > 3000 patients indicated that patients with breast cancer with high uPA/PAI-1 values derive a significantly greater benefit from adjuvant chemotherapy than patients with low uPA/PAI-1 levels. Similarly, in the multicenter prospective Chemo N0 trial, administration of cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy led to a substantial reduction in risk of disease recurrence in patients with high uPA/PAI-1. However, benefit from adjuvant endocrine therapy appears to be independent of a patient's uPA/PAI-1 status. In metastatic breast cancer, retrospective studies showed that elevated uPA or PAI-1 present in the primary tumor tissue are associated with a poor response to later palliative endocrine therapy. These findings suggest that high levels of uPA and/or PAI-1 do reflect an aggressive phenotype that may be overcome or suppressed by early systemic therapy in the adjuvant setting but may be too advanced for response to palliative therapy at a later stage." @default.
- W2039176282 created "2016-06-24" @default.
- W2039176282 creator A5001617286 @default.
- W2039176282 creator A5022444628 @default.
- W2039176282 creator A5023638355 @default.
- W2039176282 creator A5027231412 @default.
- W2039176282 creator A5033215285 @default.
- W2039176282 creator A5047836442 @default.
- W2039176282 creator A5065210354 @default.
- W2039176282 creator A5066680524 @default.
- W2039176282 creator A5079436601 @default.
- W2039176282 date "2004-12-01" @default.
- W2039176282 modified "2023-09-23" @default.
- W2039176282 title "Urokinase-Type Plasminogen Activator and Its Inhibitor Type 1 Predict Disease Outcome and Therapy Response in Primary Breast Cancer" @default.
- W2039176282 cites W1970797634 @default.
- W2039176282 cites W1996881264 @default.
- W2039176282 cites W2005113904 @default.
- W2039176282 cites W2032809211 @default.
- W2039176282 cites W2073582034 @default.
- W2039176282 cites W2091842478 @default.
- W2039176282 cites W2096025008 @default.
- W2039176282 cites W2115581335 @default.
- W2039176282 cites W2128985829 @default.
- W2039176282 cites W2150776809 @default.
- W2039176282 cites W2155498341 @default.
- W2039176282 cites W2160450758 @default.
- W2039176282 cites W2177606629 @default.
- W2039176282 cites W2323421875 @default.
- W2039176282 cites W2405442768 @default.
- W2039176282 cites W4256508844 @default.
- W2039176282 doi "https://doi.org/10.3816/cbc.2004.n.040" @default.
- W2039176282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15585071" @default.
- W2039176282 hasPublicationYear "2004" @default.
- W2039176282 type Work @default.
- W2039176282 sameAs 2039176282 @default.
- W2039176282 citedByCount "95" @default.
- W2039176282 countsByYear W20391762822012 @default.
- W2039176282 countsByYear W20391762822013 @default.
- W2039176282 countsByYear W20391762822014 @default.
- W2039176282 countsByYear W20391762822015 @default.
- W2039176282 countsByYear W20391762822016 @default.
- W2039176282 countsByYear W20391762822017 @default.
- W2039176282 countsByYear W20391762822018 @default.
- W2039176282 countsByYear W20391762822019 @default.
- W2039176282 countsByYear W20391762822020 @default.
- W2039176282 countsByYear W20391762822022 @default.
- W2039176282 crossrefType "journal-article" @default.
- W2039176282 hasAuthorship W2039176282A5001617286 @default.
- W2039176282 hasAuthorship W2039176282A5022444628 @default.
- W2039176282 hasAuthorship W2039176282A5023638355 @default.
- W2039176282 hasAuthorship W2039176282A5027231412 @default.
- W2039176282 hasAuthorship W2039176282A5033215285 @default.
- W2039176282 hasAuthorship W2039176282A5047836442 @default.
- W2039176282 hasAuthorship W2039176282A5065210354 @default.
- W2039176282 hasAuthorship W2039176282A5066680524 @default.
- W2039176282 hasAuthorship W2039176282A5079436601 @default.
- W2039176282 hasConcept C121608353 @default.
- W2039176282 hasConcept C126322002 @default.
- W2039176282 hasConcept C143998085 @default.
- W2039176282 hasConcept C2776694085 @default.
- W2039176282 hasConcept C2776755627 @default.
- W2039176282 hasConcept C2777982462 @default.
- W2039176282 hasConcept C2779679481 @default.
- W2039176282 hasConcept C530470458 @default.
- W2039176282 hasConcept C71924100 @default.
- W2039176282 hasConceptScore W2039176282C121608353 @default.
- W2039176282 hasConceptScore W2039176282C126322002 @default.
- W2039176282 hasConceptScore W2039176282C143998085 @default.
- W2039176282 hasConceptScore W2039176282C2776694085 @default.
- W2039176282 hasConceptScore W2039176282C2776755627 @default.
- W2039176282 hasConceptScore W2039176282C2777982462 @default.
- W2039176282 hasConceptScore W2039176282C2779679481 @default.
- W2039176282 hasConceptScore W2039176282C530470458 @default.
- W2039176282 hasConceptScore W2039176282C71924100 @default.
- W2039176282 hasIssue "5" @default.
- W2039176282 hasLocation W20391762821 @default.
- W2039176282 hasLocation W20391762822 @default.
- W2039176282 hasOpenAccess W2039176282 @default.
- W2039176282 hasPrimaryLocation W20391762821 @default.
- W2039176282 hasRelatedWork W2348231456 @default.
- W2039176282 hasRelatedWork W2354050160 @default.
- W2039176282 hasRelatedWork W2365277249 @default.
- W2039176282 hasRelatedWork W2367105124 @default.
- W2039176282 hasRelatedWork W2368979736 @default.
- W2039176282 hasRelatedWork W2369039771 @default.
- W2039176282 hasRelatedWork W2379151083 @default.
- W2039176282 hasRelatedWork W2388730008 @default.
- W2039176282 hasRelatedWork W2791179561 @default.
- W2039176282 hasRelatedWork W4214554217 @default.
- W2039176282 hasVolume "5" @default.
- W2039176282 isParatext "false" @default.
- W2039176282 isRetracted "false" @default.
- W2039176282 magId "2039176282" @default.
- W2039176282 workType "article" @default.