FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039194013> ?p ?o ?g. }

• W2039194013 endingPage "145" @default.
• W2039194013 startingPage "135" @default.
• W2039194013 abstract "In this study we used liver neoplasms induced by several chemical carcinogens to investigate potential nuclear targets associated with beta-catenin/Wnt signaling and potential membrane-associated beta-catenin binding partners. Strong expression of cyclin D1, in a pattern similar to that observed previously for beta-catenin, was observed by Western analysis for all five hepatoblastomas examined regardless of treatment. Increased expression of cyclin D1 was also detected in 12 of 35 (34%) hepatocellular neoplasms. Ten of 15 tumors (67%) that had mutations in the Catnb gene had upregulation of cyclin D1, while only 2 of 20 tumors (10%) without Catnb mutations had increased cyclin D1 expression. Immunohistochemical analysis confirmed strong expression of cyclin D1 in most nuclei of hepatoblastomas and scattered nuclear staining in hepatocellular tumors that had Catnb mutations. Increased c-Jun expression was observed in 19 of 30 (63%) hepatocellular tumors and all hepatoblastomas, although upregulation was not completely correlated with Catnb mutation. C-Myc expression was not increased in the tumors. Reduced expression of E-cadherin, which interacts with beta-catenin at the membrane, was observed in some tumors, but this did not correlate with Catnb mutation. Expression of the epidermal growth factor receptor, which may have a role in beta-catenin tyrosine phosphorylation, was lower in some tumors than in normal tissue depending on chemical treatment. The results provide evidence that increased expression of cyclin D1 and c-Jun may provide an advantage during tumor progression and in the transition from hepatocellular neoplasms to hepatoblastomas. Moreover, it is likely increased cyclin D1 expression results at least in part from Catnb mutation, beta-catenin accumulation, and increased Wnt signaling." @default.
• W2039194013 created "2016-06-24" @default.
• W2039194013 creator A5011105647 @default.
• W2039194013 creator A5012922006 @default.
• W2039194013 creator A5086073952 @default.
• W2039194013 creator A5089257042 @default.
• W2039194013 date "2003-07-01" @default.
• W2039194013 modified "2023-09-27" @default.
• W2039194013 title "Expression of potential β-catenin targets, cyclin D1, c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice" @default.
• W2039194013 cites W1554815317 @default.
• W2039194013 cites W1967137553 @default.
• W2039194013 cites W1968619142 @default.
• W2039194013 cites W1973046279 @default.
• W2039194013 cites W1987944557 @default.
• W2039194013 cites W1990563353 @default.
• W2039194013 cites W1992772703 @default.
• W2039194013 cites W1993255107 @default.
• W2039194013 cites W1994219871 @default.
• W2039194013 cites W1998523803 @default.
• W2039194013 cites W2000476522 @default.
• W2039194013 cites W2002404925 @default.
• W2039194013 cites W2014995450 @default.
• W2039194013 cites W2041123249 @default.
• W2039194013 cites W2047602605 @default.
• W2039194013 cites W2074339256 @default.
• W2039194013 cites W2082294278 @default.
• W2039194013 cites W2082965102 @default.
• W2039194013 cites W2108590677 @default.
• W2039194013 cites W2109069210 @default.
• W2039194013 cites W2122829982 @default.
• W2039194013 cites W2126553652 @default.
• W2039194013 cites W2128739161 @default.
• W2039194013 cites W2332035597 @default.
• W2039194013 doi "https://doi.org/10.1016/s0041-008x(03)00170-4" @default.
• W2039194013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12878043" @default.
• W2039194013 hasPublicationYear "2003" @default.
• W2039194013 type Work @default.
• W2039194013 sameAs 2039194013 @default.
• W2039194013 citedByCount "47" @default.
• W2039194013 countsByYear W20391940132012 @default.
• W2039194013 countsByYear W20391940132013 @default.
• W2039194013 countsByYear W20391940132015 @default.
• W2039194013 countsByYear W20391940132016 @default.
• W2039194013 countsByYear W20391940132017 @default.
• W2039194013 countsByYear W20391940132018 @default.
• W2039194013 countsByYear W20391940132019 @default.
• W2039194013 countsByYear W20391940132022 @default.
• W2039194013 crossrefType "journal-article" @default.
• W2039194013 hasAuthorship W2039194013A5011105647 @default.
• W2039194013 hasAuthorship W2039194013A5012922006 @default.
• W2039194013 hasAuthorship W2039194013A5086073952 @default.
• W2039194013 hasAuthorship W2039194013A5089257042 @default.
• W2039194013 hasConcept C104317684 @default.
• W2039194013 hasConcept C120089663 @default.
• W2039194013 hasConcept C121608353 @default.
• W2039194013 hasConcept C127561419 @default.
• W2039194013 hasConcept C137620995 @default.
• W2039194013 hasConcept C199835354 @default.
• W2039194013 hasConcept C203014093 @default.
• W2039194013 hasConcept C204232928 @default.
• W2039194013 hasConcept C2779324961 @default.
• W2039194013 hasConcept C29537977 @default.
• W2039194013 hasConcept C502942594 @default.
• W2039194013 hasConcept C54355233 @default.
• W2039194013 hasConcept C62478195 @default.
• W2039194013 hasConcept C86803240 @default.
• W2039194013 hasConcept C95444343 @default.
• W2039194013 hasConceptScore W2039194013C104317684 @default.
• W2039194013 hasConceptScore W2039194013C120089663 @default.
• W2039194013 hasConceptScore W2039194013C121608353 @default.
• W2039194013 hasConceptScore W2039194013C127561419 @default.
• W2039194013 hasConceptScore W2039194013C137620995 @default.
• W2039194013 hasConceptScore W2039194013C199835354 @default.
• W2039194013 hasConceptScore W2039194013C203014093 @default.
• W2039194013 hasConceptScore W2039194013C204232928 @default.
• W2039194013 hasConceptScore W2039194013C2779324961 @default.
• W2039194013 hasConceptScore W2039194013C29537977 @default.
• W2039194013 hasConceptScore W2039194013C502942594 @default.
• W2039194013 hasConceptScore W2039194013C54355233 @default.
• W2039194013 hasConceptScore W2039194013C62478195 @default.
• W2039194013 hasConceptScore W2039194013C86803240 @default.
• W2039194013 hasConceptScore W2039194013C95444343 @default.
• W2039194013 hasIssue "2" @default.
• W2039194013 hasLocation W20391940131 @default.
• W2039194013 hasLocation W20391940132 @default.
• W2039194013 hasOpenAccess W2039194013 @default.
• W2039194013 hasPrimaryLocation W20391940131 @default.
• W2039194013 hasRelatedWork W2050712818 @default.
• W2039194013 hasRelatedWork W2081291037 @default.
• W2039194013 hasRelatedWork W2129293703 @default.
• W2039194013 hasRelatedWork W2146122330 @default.
• W2039194013 hasRelatedWork W2382776397 @default.
• W2039194013 hasRelatedWork W2467618102 @default.
• W2039194013 hasRelatedWork W2762525387 @default.
• W2039194013 hasRelatedWork W2892174226 @default.
• W2039194013 hasRelatedWork W3144358926 @default.
• W2039194013 hasRelatedWork W4313395918 @default.
• W2039194013 hasVolume "190" @default.

• next