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- W2039202014 abstract "Homoplasmy is a basic genetic state of mitochondria, in which all of the hundreds to thousands of mitochondrial (mt)DNA copies within a cell or an individual have the same nucleotide-sequence. It was recently found that vegetative segregation to generate homoplasmic cells is an active process under genetic control. In the yeast Saccharomyces cerevisiae, the Mhr1 protein which catalyzes a key reaction in mtDNA homologous recombination, plays a pivotal role in vegetative segregation. Conversely, within the nuclear genome, homologous DNA recombination causes genetic diversity. Considering these contradictory roles of this key reaction in DNA recombination, possible functions of homoplasmy are discussed." @default.
- W2039202014 created "2016-06-24" @default.
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- W2039202014 date "2007-02-01" @default.
- W2039202014 modified "2023-09-27" @default.
- W2039202014 title "DNA recombination protein-dependent mechanism of homoplasmy and its proposed functions" @default.
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- W2039202014 doi "https://doi.org/10.1016/j.mito.2006.11.024" @default.
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