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• W2039210018 endingPage "88" @default.
• W2039210018 startingPage "7079" @default.
• W2039210018 abstract "Expression of transforming growth factor alpha (TGFalpha), a member of the epidermal growth factor (EGF) family, is a general response of adult murine motoneurons to genetic and experimental lesions, TGFalpha appearing as an inducer of astrogliosis in these situations. Here we address the possibility that TGFalpha expression is not specific to pathological situations but may participate to the embryonic development of motoneurons. mRNA of TGFalpha and its receptor, the EGF receptor (EGFR), were detected by ribonuclease protection assay in the ventral part of the cervical spinal cord from embryonic day 12 (E12) until adult ages. Reverse transcription-PCR amplification of their transcripts from immunopurified E15 motoneurons, associated with in situ double-immunohistological assays, identified embryonic motoneurons as cellular sources of the TGFalpha-EGFR couple. In vitro, TGFalpha promoted the survival of immunopurified E15 motoneurons in a dose-dependent manner, with a magnitude similar to BDNF neuroprotective effects at equivalent concentrations. In a transgenic mouse expressing a human TGFalpha transgene under the control of the metallothionein 1 promoter, axotomy of the facial nerve provoked significantly less degeneration in the relevant motor pool of 1-week-old mice than in wild-type animals. No protection was observed in neonates, when the transgene exhibits only weak expression levels in the brainstem. In conclusion, our results point to TGFalpha as a physiologically relevant candidate for a neurotrophic role on developing motoneurons. Its expression by the embryonic motoneurons, which also synthesize its receptor, suggests that this chemokine is endowed with the capability to promote motoneuron survival in an autocrine-paracrine manner." @default.
• W2039210018 created "2016-06-24" @default.
• W2039210018 creator A5018387769 @default.
• W2039210018 creator A5063313067 @default.
• W2039210018 creator A5063505336 @default.
• W2039210018 creator A5080792840 @default.
• W2039210018 creator A5091605363 @default.
• W2039210018 date "2001-09-15" @default.
• W2039210018 modified "2023-10-17" @default.
• W2039210018 title "Transforming growth factor alpha: a promoter of motoneuron survival of potential biological relevance." @default.
• W2039210018 cites W1490707732 @default.
• W2039210018 cites W1554054932 @default.
• W2039210018 cites W1591551951 @default.
• W2039210018 cites W1636162490 @default.
• W2039210018 cites W1651337007 @default.
• W2039210018 cites W1869834948 @default.
• W2039210018 cites W1898295630 @default.
• W2039210018 cites W1936791884 @default.
• W2039210018 cites W1964309940 @default.
• W2039210018 cites W1972036696 @default.
• W2039210018 cites W1976857475 @default.
• W2039210018 cites W1976999923 @default.
• W2039210018 cites W1977350867 @default.
• W2039210018 cites W1977609618 @default.
• W2039210018 cites W1977707793 @default.
• W2039210018 cites W1978276254 @default.
• W2039210018 cites W1978596328 @default.
• W2039210018 cites W1981238340 @default.
• W2039210018 cites W1982882974 @default.
• W2039210018 cites W1983673947 @default.
• W2039210018 cites W1983777466 @default.
• W2039210018 cites W1984684782 @default.
• W2039210018 cites W1986335023 @default.
• W2039210018 cites W1989434542 @default.
• W2039210018 cites W1991152935 @default.
• W2039210018 cites W1994071831 @default.
• W2039210018 cites W1994452959 @default.
• W2039210018 cites W1999238264 @default.
• W2039210018 cites W1999805805 @default.
• W2039210018 cites W2001684443 @default.
• W2039210018 cites W2002273560 @default.
• W2039210018 cites W2004493177 @default.
• W2039210018 cites W2005994034 @default.
• W2039210018 cites W2011642803 @default.
• W2039210018 cites W2011896419 @default.
• W2039210018 cites W2012928993 @default.
• W2039210018 cites W2013331112 @default.
• W2039210018 cites W2015882344 @default.
• W2039210018 cites W2016446826 @default.
• W2039210018 cites W2017891937 @default.
• W2039210018 cites W2018068734 @default.
• W2039210018 cites W2019864299 @default.
• W2039210018 cites W2021658407 @default.
• W2039210018 cites W2025342494 @default.
• W2039210018 cites W2025972963 @default.
• W2039210018 cites W2030393022 @default.
• W2039210018 cites W2030789321 @default.
• W2039210018 cites W2033160367 @default.
• W2039210018 cites W2033828028 @default.
• W2039210018 cites W2033836165 @default.
• W2039210018 cites W2040142253 @default.
• W2039210018 cites W2045644801 @default.
• W2039210018 cites W2046739492 @default.
• W2039210018 cites W2067376187 @default.
• W2039210018 cites W2073297965 @default.
• W2039210018 cites W2074369656 @default.
• W2039210018 cites W2074511156 @default.
• W2039210018 cites W2079860906 @default.
• W2039210018 cites W2080692154 @default.
• W2039210018 cites W2082460645 @default.
• W2039210018 cites W2088690191 @default.
• W2039210018 cites W2089163904 @default.
• W2039210018 cites W2090561457 @default.
• W2039210018 cites W2099583536 @default.
• W2039210018 cites W2099890567 @default.
• W2039210018 cites W2099976535 @default.
• W2039210018 cites W2101849511 @default.
• W2039210018 cites W2102469270 @default.
• W2039210018 cites W2128454299 @default.
• W2039210018 cites W2134812217 @default.
• W2039210018 cites W2143508222 @default.
• W2039210018 cites W2162073357 @default.
• W2039210018 cites W2166654160 @default.
• W2039210018 cites W2168418943 @default.
• W2039210018 cites W2293142484 @default.
• W2039210018 cites W2346002398 @default.
• W2039210018 cites W969128459 @default.
• W2039210018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6762970" @default.
• W2039210018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11549718" @default.
• W2039210018 hasPublicationYear "2001" @default.
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