FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039216520> ?p ?o ?g. }

• W2039216520 endingPage "168" @default.
• W2039216520 startingPage "161" @default.
• W2039216520 abstract "Amylin, calcitonin gene-related peptide (CGRP) and calcitonin are structurally related peptides with overlapping peripheral and central actions. Amylin and calcitonin excite the majority of neurones in the subfornical organ (SFO), where high densities of so-called C-type G-protein-coupled receptors have been detected. Subcutaneous injection of these hormones stimulates drinking similar to angiotensin II (ANGII), a dipsogen acting via the SFO. We now show that in addition to amylin and rat calcitonin (rCT), CGRP and salmon calcitonin (sCT) also excite SFO neurones. In extracellular recordings of an in vitro slice preparation of the SFO, 78% of all neurones (n=31) superfused with CGRP (10(-6) M) were excited. The excitatory effect was dose-dependent and reversible with an average threshold concentration of 5x10(-7) M, which is approximately 15-fold higher than reported for amylin-induced excitations. sCT (10(-7) M), which behaves as a non-competitive agonist at amylin as well as calcitonin receptors, caused irreversible excitatory responses in 96% of all recordings (n=26). Amylin-, CRGP- and rCT-induced excitations could be blocked by the selective amylin receptor antagonist AC187 (10(-5) to 10(-6) M), whereas sCT-induced excitations were not inhibited. The receptor antagonist human CGRP(8-37) (10(-6) M) partly caused agonistic responses, but did not block CGRP-induced excitations. The pharmacological profile observed in the present work, and in a recent publication using the same preparation, indicating (1) that CGRP is a weaker agonist in the SFO than amylin, (2) that sCT excites SFO neurones, and (3) that responses are blocked by AC187 but not by CGRP(8-37), is inconsistent with activation via CGRP receptors, but is instead consistent with involvement of amylin (C3) and calcitonin (C1) receptors, which are co-localized to a high degree on the same subset of SFO-neurones. We propose that it is unlikely that blood-borne CGRP has a significant effect on neurones in the SFO." @default.
• W2039216520 created "2016-06-24" @default.
• W2039216520 creator A5029760327 @default.
• W2039216520 creator A5045376870 @default.
• W2039216520 creator A5079166638 @default.
• W2039216520 creator A5083636719 @default.
• W2039216520 date "1999-08-01" @default.
• W2039216520 modified "2023-10-18" @default.
• W2039216520 title "Pharmacological characterisation of amylin-related peptides activating subfornical organ neurones" @default.
• W2039216520 cites W1514346 @default.
• W2039216520 cites W1551244913 @default.
• W2039216520 cites W1928687819 @default.
• W2039216520 cites W1978259628 @default.
• W2039216520 cites W1991637403 @default.
• W2039216520 cites W2009155874 @default.
• W2039216520 cites W2009450398 @default.
• W2039216520 cites W2011141406 @default.
• W2039216520 cites W2018895555 @default.
• W2039216520 cites W2020840757 @default.
• W2039216520 cites W2024019669 @default.
• W2039216520 cites W2025663580 @default.
• W2039216520 cites W2027113419 @default.
• W2039216520 cites W2029911765 @default.
• W2039216520 cites W2043654095 @default.
• W2039216520 cites W2067231489 @default.
• W2039216520 cites W2068202200 @default.
• W2039216520 cites W2084172070 @default.
• W2039216520 cites W2111112233 @default.
• W2039216520 cites W2117309485 @default.
• W2039216520 cites W2151702699 @default.
• W2039216520 cites W2413269693 @default.
• W2039216520 doi "https://doi.org/10.1016/s0006-8993(99)01697-2" @default.
• W2039216520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10433998" @default.
• W2039216520 hasPublicationYear "1999" @default.
• W2039216520 type Work @default.
• W2039216520 sameAs 2039216520 @default.
• W2039216520 citedByCount "41" @default.
• W2039216520 countsByYear W20392165202012 @default.
• W2039216520 countsByYear W20392165202013 @default.
• W2039216520 countsByYear W20392165202014 @default.
• W2039216520 countsByYear W20392165202015 @default.
• W2039216520 countsByYear W20392165202017 @default.
• W2039216520 countsByYear W20392165202020 @default.
• W2039216520 countsByYear W20392165202022 @default.
• W2039216520 crossrefType "journal-article" @default.
• W2039216520 hasAuthorship W2039216520A5029760327 @default.
• W2039216520 hasAuthorship W2039216520A5045376870 @default.
• W2039216520 hasAuthorship W2039216520A5079166638 @default.
• W2039216520 hasAuthorship W2039216520A5083636719 @default.
• W2039216520 hasConcept C118303440 @default.
• W2039216520 hasConcept C126322002 @default.
• W2039216520 hasConcept C134018914 @default.
• W2039216520 hasConcept C163170386 @default.
• W2039216520 hasConcept C165220095 @default.
• W2039216520 hasConcept C170493617 @default.
• W2039216520 hasConcept C185592680 @default.
• W2039216520 hasConcept C2776885963 @default.
• W2039216520 hasConcept C2778938600 @default.
• W2039216520 hasConcept C2779306644 @default.
• W2039216520 hasConcept C2779627488 @default.
• W2039216520 hasConcept C2780705028 @default.
• W2039216520 hasConcept C2908929049 @default.
• W2039216520 hasConcept C71924100 @default.
• W2039216520 hasConcept C86803240 @default.
• W2039216520 hasConceptScore W2039216520C118303440 @default.
• W2039216520 hasConceptScore W2039216520C126322002 @default.
• W2039216520 hasConceptScore W2039216520C134018914 @default.
• W2039216520 hasConceptScore W2039216520C163170386 @default.
• W2039216520 hasConceptScore W2039216520C165220095 @default.
• W2039216520 hasConceptScore W2039216520C170493617 @default.
• W2039216520 hasConceptScore W2039216520C185592680 @default.
• W2039216520 hasConceptScore W2039216520C2776885963 @default.
• W2039216520 hasConceptScore W2039216520C2778938600 @default.
• W2039216520 hasConceptScore W2039216520C2779306644 @default.
• W2039216520 hasConceptScore W2039216520C2779627488 @default.
• W2039216520 hasConceptScore W2039216520C2780705028 @default.
• W2039216520 hasConceptScore W2039216520C2908929049 @default.
• W2039216520 hasConceptScore W2039216520C71924100 @default.
• W2039216520 hasConceptScore W2039216520C86803240 @default.
• W2039216520 hasIssue "1-2" @default.
• W2039216520 hasLocation W20392165201 @default.
• W2039216520 hasLocation W20392165202 @default.
• W2039216520 hasOpenAccess W2039216520 @default.
• W2039216520 hasPrimaryLocation W20392165201 @default.
• W2039216520 hasRelatedWork W1943192612 @default.
• W2039216520 hasRelatedWork W1966022945 @default.
• W2039216520 hasRelatedWork W1990414706 @default.
• W2039216520 hasRelatedWork W2003450342 @default.
• W2039216520 hasRelatedWork W2085871851 @default.
• W2039216520 hasRelatedWork W2136463004 @default.
• W2039216520 hasRelatedWork W2169259278 @default.
• W2039216520 hasRelatedWork W2312430269 @default.
• W2039216520 hasRelatedWork W2409125344 @default.
• W2039216520 hasRelatedWork W4290348824 @default.
• W2039216520 hasVolume "837" @default.
• W2039216520 isParatext "false" @default.
• W2039216520 isRetracted "false" @default.
• W2039216520 magId "2039216520" @default.

• next