FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039220360> ?p ?o ?g. }

• W2039220360 endingPage "56" @default.
• W2039220360 startingPage "49" @default.
• W2039220360 abstract "Allogeneic peripheral blood progenitor cells (PBPCs) have mostly been mobilized by granulocyte colony-stimulating factor (G-CSF). There is neither clinical nor experimental data available addressing the question if other hematopoietic growth factors or combinations thereof might influence engraftment, graft-versus-host disease (GvHD), and graft-versus-leukemia (GvL) effects after allogeneic peripheral blood progenitor cell transplantation (PBPCT). We used a murine model to investigate these parameters after transplantation of PBPCs mobilized with G-CSF and SCF either alone or in combination. Treatment of splenectomized DBA and Balb/c mice with 250 μg/kg/day G-CSF for 5 days resulted in an increase of CFU-gm from 0 to 53/μl. The highest progenitor cell numbers (147/μl) were observed after treatment with 100 μg/kg/day SCF administered in conjunction with G-SCF. No differences were detected with regard to the number of T cells (CD3+), T cell subsets (CD4+, CD8+), B cells (CD19+) and NK cells (NK1.1+) in PBPC grafts mobilized by G-CSF plus SCF compared to those mobilized with G-CSF alone. The antileukemic activity of syngeneic and MHC-identical allogeneic PBPC grafts was investigated in lethally irradiated Balb/c mice bearing the B-lymphatic leukemia cell line A20. In this model, PBPCs mobilized by G-CSF plus SCF exerted a significantly higher antileukemic activity compared to grafts mobilized by G-CSF alone (94 vs 71% freedom from leukemia at day 100, P<0.05). The antileukemic effect was lowest after BMT (38% freedom from leukemia). Since significant differences in the incidence of lethal GvHD were not observed, improved GVL-activity resulted in superior overall survival. Our data demonstrate that the utilization of specific hematopoietic growth factors not only improve the yield of hematopoietic progenitor cells but can also significantly enhance the immunotherapeutic potential of allografts." @default.
• W2039220360 created "2016-06-24" @default.
• W2039220360 creator A5002498295 @default.
• W2039220360 creator A5039235274 @default.
• W2039220360 creator A5039643813 @default.
• W2039220360 creator A5057398513 @default.
• W2039220360 creator A5060155106 @default.
• W2039220360 creator A5085146093 @default.
• W2039220360 creator A5086135617 @default.
• W2039220360 date "2003-06-23" @default.
• W2039220360 modified "2023-10-12" @default.
• W2039220360 title "Enhanced antileukemic activity of allogeneic peripheral blood progenitor cell transplants following donor treatment with the combination of granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) in a murine transplantation model" @default.
• W2039220360 cites W1256794680 @default.
• W2039220360 cites W1604668557 @default.
• W2039220360 cites W162415999 @default.
• W2039220360 cites W1842423069 @default.
• W2039220360 cites W190201512 @default.
• W2039220360 cites W1976183578 @default.
• W2039220360 cites W1988855837 @default.
• W2039220360 cites W2001283066 @default.
• W2039220360 cites W2035147988 @default.
• W2039220360 cites W2045204290 @default.
• W2039220360 cites W2066790739 @default.
• W2039220360 cites W2076724485 @default.
• W2039220360 cites W2078660810 @default.
• W2039220360 cites W2095962660 @default.
• W2039220360 cites W2097069418 @default.
• W2039220360 cites W2168048025 @default.
• W2039220360 cites W2170933182 @default.
• W2039220360 cites W218195593 @default.
• W2039220360 cites W2274303087 @default.
• W2039220360 cites W2286707908 @default.
• W2039220360 cites W2292001986 @default.
• W2039220360 cites W2302003442 @default.
• W2039220360 cites W2324449270 @default.
• W2039220360 cites W2335097692 @default.
• W2039220360 cites W2335261075 @default.
• W2039220360 cites W2337680764 @default.
• W2039220360 cites W2337976783 @default.
• W2039220360 cites W2338191126 @default.
• W2039220360 cites W2343294262 @default.
• W2039220360 cites W2343448346 @default.
• W2039220360 cites W2343492792 @default.
• W2039220360 cites W2407768420 @default.
• W2039220360 cites W2415300244 @default.
• W2039220360 cites W2417849984 @default.
• W2039220360 cites W2418745023 @default.
• W2039220360 cites W2418932463 @default.
• W2039220360 cites W279961367 @default.
• W2039220360 cites W289749226 @default.
• W2039220360 cites W324624459 @default.
• W2039220360 cites W4240698417 @default.
• W2039220360 cites W4251093572 @default.
• W2039220360 cites W4254579396 @default.
• W2039220360 cites W79123086 @default.
• W2039220360 doi "https://doi.org/10.1038/sj.bmt.1704072" @default.
• W2039220360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12815478" @default.
• W2039220360 hasPublicationYear "2003" @default.
• W2039220360 type Work @default.
• W2039220360 sameAs 2039220360 @default.
• W2039220360 citedByCount "4" @default.
• W2039220360 countsByYear W20392203602014 @default.
• W2039220360 crossrefType "journal-article" @default.
• W2039220360 hasAuthorship W2039220360A5002498295 @default.
• W2039220360 hasAuthorship W2039220360A5039235274 @default.
• W2039220360 hasAuthorship W2039220360A5039643813 @default.
• W2039220360 hasAuthorship W2039220360A5057398513 @default.
• W2039220360 hasAuthorship W2039220360A5060155106 @default.
• W2039220360 hasAuthorship W2039220360A5085146093 @default.
• W2039220360 hasAuthorship W2039220360A5086135617 @default.
• W2039220360 hasBestOaLocation W20392203601 @default.
• W2039220360 hasConcept C109159458 @default.
• W2039220360 hasConcept C126322002 @default.
• W2039220360 hasConcept C167672396 @default.
• W2039220360 hasConcept C201750760 @default.
• W2039220360 hasConcept C2022786 @default.
• W2039220360 hasConcept C203014093 @default.
• W2039220360 hasConcept C2776694085 @default.
• W2039220360 hasConcept C2777767877 @default.
• W2039220360 hasConcept C2778461978 @default.
• W2039220360 hasConcept C2778957590 @default.
• W2039220360 hasConcept C28328180 @default.
• W2039220360 hasConcept C2911091166 @default.
• W2039220360 hasConcept C502942594 @default.
• W2039220360 hasConcept C54355233 @default.
• W2039220360 hasConcept C71924100 @default.
• W2039220360 hasConcept C86803240 @default.
• W2039220360 hasConcept C8891405 @default.
• W2039220360 hasConceptScore W2039220360C109159458 @default.
• W2039220360 hasConceptScore W2039220360C126322002 @default.
• W2039220360 hasConceptScore W2039220360C167672396 @default.
• W2039220360 hasConceptScore W2039220360C201750760 @default.
• W2039220360 hasConceptScore W2039220360C2022786 @default.
• W2039220360 hasConceptScore W2039220360C203014093 @default.
• W2039220360 hasConceptScore W2039220360C2776694085 @default.
• W2039220360 hasConceptScore W2039220360C2777767877 @default.
• W2039220360 hasConceptScore W2039220360C2778461978 @default.
• W2039220360 hasConceptScore W2039220360C2778957590 @default.

• next