FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039220817> ?p ?o ?g. }

• W2039220817 endingPage "354" @default.
• W2039220817 startingPage "347" @default.
• W2039220817 abstract "•The PPP is critical for cancer cell survival and ribonucleotide and lipid biosynthesis. •Cancer cells modulate the PPP to maintain anabolic demands and redox homeostasis. •Targeting the PPP for cancer therapy is challenging. •Further studies on PPP regulation in cancer cells are required for targeting the PPP. The pentose phosphate pathway (PPP), which branches from glycolysis at the first committed step of glucose metabolism, is required for the synthesis of ribonucleotides and is a major source of NADPH. NADPH is required for and consumed during fatty acid synthesis and the scavenging of reactive oxygen species (ROS). Therefore, the PPP plays a pivotal role in helping glycolytic cancer cells to meet their anabolic demands and combat oxidative stress. Recently, several neoplastic lesions were shown to have evolved to facilitate the flux of glucose into the PPP. This review summarizes the fundamental functions of the PPP, its regulation in cancer cells, and its importance in cancer cell metabolism and survival. The pentose phosphate pathway (PPP), which branches from glycolysis at the first committed step of glucose metabolism, is required for the synthesis of ribonucleotides and is a major source of NADPH. NADPH is required for and consumed during fatty acid synthesis and the scavenging of reactive oxygen species (ROS). Therefore, the PPP plays a pivotal role in helping glycolytic cancer cells to meet their anabolic demands and combat oxidative stress. Recently, several neoplastic lesions were shown to have evolved to facilitate the flux of glucose into the PPP. This review summarizes the fundamental functions of the PPP, its regulation in cancer cells, and its importance in cancer cell metabolism and survival." @default.
• W2039220817 created "2016-06-24" @default.
• W2039220817 creator A5021161819 @default.
• W2039220817 creator A5061829398 @default.
• W2039220817 date "2014-08-01" @default.
• W2039220817 modified "2023-10-17" @default.
• W2039220817 title "The pentose phosphate pathway and cancer" @default.
• W2039220817 cites W109810485 @default.
• W2039220817 cites W1497863497 @default.
• W2039220817 cites W1523040131 @default.
• W2039220817 cites W1611606593 @default.
• W2039220817 cites W1658821746 @default.
• W2039220817 cites W1785455093 @default.
• W2039220817 cites W1973454751 @default.
• W2039220817 cites W1982219839 @default.
• W2039220817 cites W1982817635 @default.
• W2039220817 cites W1983746940 @default.
• W2039220817 cites W1990755444 @default.
• W2039220817 cites W1992372128 @default.
• W2039220817 cites W1992501047 @default.
• W2039220817 cites W1992724001 @default.
• W2039220817 cites W2006294797 @default.
• W2039220817 cites W2013583349 @default.
• W2039220817 cites W2015384831 @default.
• W2039220817 cites W2016535776 @default.
• W2039220817 cites W2018299587 @default.
• W2039220817 cites W2023326549 @default.
• W2039220817 cites W2023947368 @default.
• W2039220817 cites W2024367581 @default.
• W2039220817 cites W2031039449 @default.
• W2039220817 cites W2031100736 @default.
• W2039220817 cites W2031526143 @default.
• W2039220817 cites W2032522782 @default.
• W2039220817 cites W2033633352 @default.
• W2039220817 cites W2035608099 @default.
• W2039220817 cites W2039193773 @default.
• W2039220817 cites W2046100445 @default.
• W2039220817 cites W2046332840 @default.
• W2039220817 cites W2051173337 @default.
• W2039220817 cites W2053047691 @default.
• W2039220817 cites W2057990702 @default.
• W2039220817 cites W2059318458 @default.
• W2039220817 cites W2069269337 @default.
• W2039220817 cites W2069651098 @default.
• W2039220817 cites W2072549244 @default.
• W2039220817 cites W2073332412 @default.
• W2039220817 cites W2074892828 @default.
• W2039220817 cites W2075914357 @default.
• W2039220817 cites W2076315300 @default.
• W2039220817 cites W2078530058 @default.
• W2039220817 cites W2082789532 @default.
• W2039220817 cites W2083975795 @default.
• W2039220817 cites W2087757787 @default.
• W2039220817 cites W2093792755 @default.
• W2039220817 cites W2093985232 @default.
• W2039220817 cites W2094714679 @default.
• W2039220817 cites W2098720660 @default.
• W2039220817 cites W2100628426 @default.
• W2039220817 cites W2108228283 @default.
• W2039220817 cites W2111768081 @default.
• W2039220817 cites W2112143589 @default.
• W2039220817 cites W2119239003 @default.
• W2039220817 cites W2122238728 @default.
• W2039220817 cites W2122826701 @default.
• W2039220817 cites W2123708141 @default.
• W2039220817 cites W2137741805 @default.
• W2039220817 cites W2138271341 @default.
• W2039220817 cites W2140161746 @default.
• W2039220817 cites W2141603634 @default.
• W2039220817 cites W2152937132 @default.
• W2039220817 cites W2166031628 @default.
• W2039220817 cites W2169695895 @default.
• W2039220817 cites W2310841469 @default.
• W2039220817 cites W2341758899 @default.
• W2039220817 doi "https://doi.org/10.1016/j.tibs.2014.06.005" @default.
• W2039220817 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4329227" @default.
• W2039220817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25037503" @default.
• W2039220817 hasPublicationYear "2014" @default.
• W2039220817 type Work @default.
• W2039220817 sameAs 2039220817 @default.
• W2039220817 citedByCount "952" @default.
• W2039220817 countsByYear W20392208172014 @default.
• W2039220817 countsByYear W20392208172015 @default.
• W2039220817 countsByYear W20392208172016 @default.
• W2039220817 countsByYear W20392208172017 @default.
• W2039220817 countsByYear W20392208172018 @default.
• W2039220817 countsByYear W20392208172019 @default.
• W2039220817 countsByYear W20392208172020 @default.
• W2039220817 countsByYear W20392208172021 @default.
• W2039220817 countsByYear W20392208172022 @default.
• W2039220817 countsByYear W20392208172023 @default.
• W2039220817 crossrefType "journal-article" @default.
• W2039220817 hasAuthorship W2039220817A5021161819 @default.
• W2039220817 hasAuthorship W2039220817A5061829398 @default.
• W2039220817 hasBestOaLocation W20392208172 @default.
• W2039220817 hasConcept C1008401 @default.
• W2039220817 hasConcept C121608353 @default.
• W2039220817 hasConcept C178790620 @default.

• next