FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039227881> ?p ?o ?g. }

• W2039227881 abstract "During DNA repair, uracil DNA glycosylase (UDG) pulls unwanted uracil into its active site through hydrogen bonding and pi-pi stacking interactions. The reason why UDG binds only uracil tightly--and not its derivatives, such as thymine--remains unclear. In this study, we synthesized the stable, water-soluble receptor 1a as a structural mimic of the active site in UDG. Compound 1a contains a 2,6-bis(glycylamino)pyridine group, which mimics the amino acid residues of UDG that interact with uracil through a hydrogen-bonding network; it also possesses a pyrene moiety as a pi-pi stacking interaction element and fluorescent probe that mimics the aromatic groups (phenyl and fluorescent indolyl units) found in the active site of UDG. Receptor 1a binds selectively to uracil and derivatives (including thymine, 5-formyluracil, 5-fluorouracil, and 5-nitrouracil) and some DNA and RNA nucleosides (including thymidine and uridine) through hydrogen bonding and pi-pi stacking interactions. Interestingly, a plot of log K(b) with respect to the values of pK(a) of the N(3)H units of uracil and its derivatives was linear, with a negative slope (beta) of -0.24 +/- 0.03. Thus, compounds featuring lower values of pK(a) for their N(3)H units provided greater apparent binding constants for their complexes with receptor 1a, suggesting acidity-dependent binding of uracil and its derivatives to this receptor; notably, uracil bound more tightly than did thymine. Our study provides some insight into how uracil and its derivatives in DNA are bound by DNA repair enzymes through hydrogen bonding and pi-pi stacking interactions." @default.
• W2039227881 created "2016-06-24" @default.
• W2039227881 creator A5011598922 @default.
• W2039227881 creator A5020683530 @default.
• W2039227881 creator A5076348977 @default.
• W2039227881 creator A5076992719 @default.
• W2039227881 creator A5084986687 @default.
• W2039227881 date "2009-12-17" @default.
• W2039227881 modified "2023-09-26" @default.
• W2039227881 title "Selective Recognition of Uracil and Its Derivatives Using a DNA Repair Enzyme Structural Mimic" @default.
• W2039227881 cites W1511852170 @default.
• W2039227881 cites W1964724705 @default.
• W2039227881 cites W1967844460 @default.
• W2039227881 cites W1972418624 @default.
• W2039227881 cites W1974796420 @default.
• W2039227881 cites W1979749286 @default.
• W2039227881 cites W1982787267 @default.
• W2039227881 cites W1983003552 @default.
• W2039227881 cites W1991418410 @default.
• W2039227881 cites W1992100298 @default.
• W2039227881 cites W1995573025 @default.
• W2039227881 cites W1997203477 @default.
• W2039227881 cites W2003134554 @default.
• W2039227881 cites W2006318352 @default.
• W2039227881 cites W2006420271 @default.
• W2039227881 cites W2007730035 @default.
• W2039227881 cites W2008908432 @default.
• W2039227881 cites W2012357112 @default.
• W2039227881 cites W2014551800 @default.
• W2039227881 cites W2015586003 @default.
• W2039227881 cites W2017588746 @default.
• W2039227881 cites W2018535796 @default.
• W2039227881 cites W2022842176 @default.
• W2039227881 cites W2023578860 @default.
• W2039227881 cites W2024541899 @default.
• W2039227881 cites W2029842185 @default.
• W2039227881 cites W2034434107 @default.
• W2039227881 cites W2037838723 @default.
• W2039227881 cites W2043697653 @default.
• W2039227881 cites W2046069017 @default.
• W2039227881 cites W2050088472 @default.
• W2039227881 cites W2052645319 @default.
• W2039227881 cites W2057220750 @default.
• W2039227881 cites W2058663932 @default.
• W2039227881 cites W2064075969 @default.
• W2039227881 cites W2066564669 @default.
• W2039227881 cites W2071311001 @default.
• W2039227881 cites W2077890483 @default.
• W2039227881 cites W2080306402 @default.
• W2039227881 cites W2091010656 @default.
• W2039227881 cites W2098520782 @default.
• W2039227881 cites W2106514463 @default.
• W2039227881 cites W2109529256 @default.
• W2039227881 cites W2114166108 @default.
• W2039227881 cites W2120901082 @default.
• W2039227881 cites W2137835170 @default.
• W2039227881 cites W2154244011 @default.
• W2039227881 cites W2162900968 @default.
• W2039227881 cites W2950757303 @default.
• W2039227881 doi "https://doi.org/10.1021/jo901862x" @default.
• W2039227881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20017469" @default.
• W2039227881 hasPublicationYear "2009" @default.
• W2039227881 type Work @default.
• W2039227881 sameAs 2039227881 @default.
• W2039227881 citedByCount "19" @default.
• W2039227881 countsByYear W20392278812012 @default.
• W2039227881 countsByYear W20392278812013 @default.
• W2039227881 countsByYear W20392278812014 @default.
• W2039227881 countsByYear W20392278812015 @default.
• W2039227881 countsByYear W20392278812016 @default.
• W2039227881 countsByYear W20392278812017 @default.
• W2039227881 countsByYear W20392278812018 @default.
• W2039227881 countsByYear W20392278812021 @default.
• W2039227881 countsByYear W20392278812022 @default.
• W2039227881 countsByYear W20392278812023 @default.
• W2039227881 crossrefType "journal-article" @default.
• W2039227881 hasAuthorship W2039227881A5011598922 @default.
• W2039227881 hasAuthorship W2039227881A5020683530 @default.
• W2039227881 hasAuthorship W2039227881A5076348977 @default.
• W2039227881 hasAuthorship W2039227881A5076992719 @default.
• W2039227881 hasAuthorship W2039227881A5084986687 @default.
• W2039227881 hasConcept C112887158 @default.
• W2039227881 hasConcept C134935766 @default.
• W2039227881 hasConcept C178790620 @default.
• W2039227881 hasConcept C185592680 @default.
• W2039227881 hasConcept C192396546 @default.
• W2039227881 hasConcept C2776568683 @default.
• W2039227881 hasConcept C2776858809 @default.
• W2039227881 hasConcept C2778711568 @default.
• W2039227881 hasConcept C2779554091 @default.
• W2039227881 hasConcept C32909587 @default.
• W2039227881 hasConcept C33347731 @default.
• W2039227881 hasConcept C552990157 @default.
• W2039227881 hasConcept C55493867 @default.
• W2039227881 hasConcept C71240020 @default.
• W2039227881 hasConceptScore W2039227881C112887158 @default.
• W2039227881 hasConceptScore W2039227881C134935766 @default.
• W2039227881 hasConceptScore W2039227881C178790620 @default.
• W2039227881 hasConceptScore W2039227881C185592680 @default.
• W2039227881 hasConceptScore W2039227881C192396546 @default.

• next