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- W2039231750 abstract "Opioids and opiates decrease the duration of action potentials and the amount of neurotransmitter released from sensory neurons. The mu-type opioid receptor, the binding site for morphine, is thought to act exclusively on K+ channels. Here, we show that activation of the mu receptor inhibits Ca2+ channels in rat sensory neurons; the effect is blocked by a mu antagonist and is not mimicked by kappa or delta receptor agonists. Both low-threshold (T-type) and high-threshold Ca2+ currents are partially suppressed. omega-Conotoxin-sensitive and omega-conotoxin-insensitive, high-threshold Ca2+ currents are inhibited. The kinetic effect on high-threshold current is like that caused by diminished rest potential: the transient component is selectively lost, whereas the sustained component is spared." @default.
- W2039231750 created "2016-06-24" @default.
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- W2039231750 date "1991-01-01" @default.
- W2039231750 modified "2023-10-14" @default.
- W2039231750 title "Activation of μ opioid receptors inhibits transient high- and low-threshold Ca 2+ currents, but spares a sustained current" @default.
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- W2039231750 doi "https://doi.org/10.1016/0896-6273(91)90117-i" @default.
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