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- W2039235909 abstract "Abstract The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute inhibition of IKK-ε and TBK1 with amlexanox treatment increases cAMP levels in subcutaneous adipose depots of obese mice, promoting the synthesis and secretion of the cytokine IL-6 from adipocytes and preadipocytes, but not from macrophages. IL-6, in turn, stimulates the phosphorylation of hepatic Stat3 to suppress expression of genes involved in gluconeogenesis, in the process improving glucose handling in obese mice. Preliminary data in a small cohort of obese patients show a similar association. These data support an important role for a subcutaneous adipose tissue–liver axis in mediating the acute metabolic benefits of amlexanox on glucose metabolism, and point to a new therapeutic pathway for type 2 diabetes." @default.
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- W2039235909 date "2015-01-12" @default.
- W2039235909 modified "2023-10-18" @default.
- W2039235909 title "A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis" @default.
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- W2039235909 doi "https://doi.org/10.1038/ncomms7047" @default.
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