FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039237011> ?p ?o ?g. }

• W2039237011 endingPage "224" @default.
• W2039237011 startingPage "216" @default.
• W2039237011 abstract "The effect of an acute oral load of 2 g ethanol/kg body weight was studied in a group of male and female 10-wk-old C3H/HeNCrj (C3H/He) mice to investigate gender change throughout differences of the hepatic ethanol metabolism of mice. The following parameters were measured in the serum from 0 h to 3 h after the start of the experiment: ethanol, acetaldehyde, and acetate. Their concentrations in the serum in female mice tended to show lower levels than in male mice. In female mice, the concentration of ethanol at 1 h and the concentration of acetate at 1 h, 2 h, and 3 h after ethanol administration showed significantly lower levels than in male mice. Ten-week-old male and female C3H/He mice were subcutaneously injected 50 microg/kg body weight beta-estradiol and 1.45 mmol/kg body weight testosterone propionate (testosterone) in olive oil, respectively, and changes in the activity of enzymes related to the hepatic ethanol metabolism of mice were examined at 24 h after the administration of sex hormones. The activity of the cytosolic alcohol dehydrogenase (ADH) and microsomal aniline hydroxylase (ANH) and the low Km, high Km and total aldehyde dehydrogenase (AlDH) activities in the mitochondrial, the cytosolic, and the microsomal fraction of the liver were higher. Moreover, the density of the band of CYP2E1 in the microsome in female mice was stronger than in male mice, and in the microsomal fraction of the liver, the total content of cytochrome P-450 (CYP) and ethoxyresorufin O-dealkylase (EROD) activity in male mice showed significantly higher values than in female mice. The density of the band of CYP2E1 and the three activities of AlDH in the hepatic mitochondrial fraction of male mice increased significantly under treatment with beta-estradiol. The three activities of AlDH of the cytosolic fraction of the liver in female mice significantly decreased under treatment with testosterone. The present findings suggested that in C3H/He mice livers, the rate of ethanol metabolism is faster in females than in males, and the enzymes related to ethanol metabolism are controlled by testosterone or beta-estradiol. It is suggested that ethanol and its metabolite disappear faster from the serum of female mice than from the serum of male mice because the activities of hepatic enzymes related to ethanol metabolism are higher in female mice than in male mice. C3H/He mice, hepatic ethanol metabolism, gender different, ADH, AlDH" @default.
• W2039237011 created "2016-06-24" @default.
• W2039237011 creator A5000414691 @default.
• W2039237011 creator A5004374545 @default.
• W2039237011 creator A5005082748 @default.
• W2039237011 creator A5057168639 @default.
• W2039237011 creator A5062383086 @default.
• W2039237011 creator A5066746081 @default.
• W2039237011 creator A5086677767 @default.
• W2039237011 date "2002-01-01" @default.
• W2039237011 modified "2023-10-16" @default.
• W2039237011 title "Gender-Related Differences in Mouse Hepatic Ethanol Metabolism." @default.
• W2039237011 cites W1489635319 @default.
• W2039237011 cites W1496968467 @default.
• W2039237011 cites W1506043065 @default.
• W2039237011 cites W1533807800 @default.
• W2039237011 cites W1537134958 @default.
• W2039237011 cites W1852809499 @default.
• W2039237011 cites W1852941485 @default.
• W2039237011 cites W1920770313 @default.
• W2039237011 cites W1964964343 @default.
• W2039237011 cites W1965977999 @default.
• W2039237011 cites W1967577977 @default.
• W2039237011 cites W1968784300 @default.
• W2039237011 cites W1971894785 @default.
• W2039237011 cites W1972269182 @default.
• W2039237011 cites W1979243197 @default.
• W2039237011 cites W1979454312 @default.
• W2039237011 cites W1982358260 @default.
• W2039237011 cites W1984526747 @default.
• W2039237011 cites W1984879272 @default.
• W2039237011 cites W1992295446 @default.
• W2039237011 cites W2002500242 @default.
• W2039237011 cites W2008646949 @default.
• W2039237011 cites W2008677803 @default.
• W2039237011 cites W2010063233 @default.
• W2039237011 cites W2010346458 @default.
• W2039237011 cites W2013790185 @default.
• W2039237011 cites W2017063028 @default.
• W2039237011 cites W2017201876 @default.
• W2039237011 cites W2028030841 @default.
• W2039237011 cites W2041670280 @default.
• W2039237011 cites W2056603901 @default.
• W2039237011 cites W2057787351 @default.
• W2039237011 cites W2079684382 @default.
• W2039237011 cites W2084075687 @default.
• W2039237011 cites W2088524561 @default.
• W2039237011 cites W2094372349 @default.
• W2039237011 cites W2172159364 @default.
• W2039237011 cites W2258557889 @default.
• W2039237011 cites W2316828431 @default.
• W2039237011 cites W2324761579 @default.
• W2039237011 cites W2337365529 @default.
• W2039237011 cites W2414652591 @default.
• W2039237011 cites W2418320674 @default.
• W2039237011 cites W2955761657 @default.
• W2039237011 doi "https://doi.org/10.3177/jnsv.48.216" @default.
• W2039237011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12350080" @default.
• W2039237011 hasPublicationYear "2002" @default.
• W2039237011 type Work @default.
• W2039237011 sameAs 2039237011 @default.
• W2039237011 citedByCount "24" @default.
• W2039237011 countsByYear W20392370112012 @default.
• W2039237011 countsByYear W20392370112013 @default.
• W2039237011 countsByYear W20392370112014 @default.
• W2039237011 countsByYear W20392370112015 @default.
• W2039237011 countsByYear W20392370112016 @default.
• W2039237011 countsByYear W20392370112017 @default.
• W2039237011 countsByYear W20392370112018 @default.
• W2039237011 countsByYear W20392370112020 @default.
• W2039237011 countsByYear W20392370112021 @default.
• W2039237011 countsByYear W20392370112022 @default.
• W2039237011 countsByYear W20392370112023 @default.
• W2039237011 crossrefType "journal-article" @default.
• W2039237011 hasAuthorship W2039237011A5000414691 @default.
• W2039237011 hasAuthorship W2039237011A5004374545 @default.
• W2039237011 hasAuthorship W2039237011A5005082748 @default.
• W2039237011 hasAuthorship W2039237011A5057168639 @default.
• W2039237011 hasAuthorship W2039237011A5062383086 @default.
• W2039237011 hasAuthorship W2039237011A5066746081 @default.
• W2039237011 hasAuthorship W2039237011A5086677767 @default.
• W2039237011 hasBestOaLocation W20392370111 @default.
• W2039237011 hasConcept C126322002 @default.
• W2039237011 hasConcept C134018914 @default.
• W2039237011 hasConcept C140027455 @default.
• W2039237011 hasConcept C181199279 @default.
• W2039237011 hasConcept C185592680 @default.
• W2039237011 hasConcept C25747580 @default.
• W2039237011 hasConcept C2777344606 @default.
• W2039237011 hasConcept C2777595113 @default.
• W2039237011 hasConcept C2777911890 @default.
• W2039237011 hasConcept C2779279991 @default.
• W2039237011 hasConcept C2780161600 @default.
• W2039237011 hasConcept C2781115071 @default.
• W2039237011 hasConcept C30153976 @default.
• W2039237011 hasConcept C526171541 @default.
• W2039237011 hasConcept C55493867 @default.
• W2039237011 hasConcept C62231903 @default.

• next