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• W2039242552 startingPage "471" @default.
• W2039242552 abstract "A number of derivatives of tryptamine and phenethylamine, and certain other compounds, were tested on neurones in the cerebral cortex of cats by iontophoretic release from micro-pipettes. The characteristic action of many of these compounds was a depression of the neuronal discharge initiated by synaptic activity or by the application of l-glutamate; imidazolylacetic acid, dopamine, ephedrine and ergometrine were particularly effective. Catechol amines, hydroxytryptamines and imidazolylacetic acid had a relatively quick and rapidly reversible action, not unlike that of γ-aminobutyric acid, whereas ephedrine and derivatives of lysergic acid diethylamide caused a slower and more prolonged depression of the amplitude of spikes, rather like atropine. Several compounds, including 5-hydroxytryptamine, adrenaline and ergometrine, could also excite the same neurone when larger amounts were applied. A few substances, such as dopa and methylergometrine, had a predominantly excitant action." @default.
• W2039242552 created "2016-06-24" @default.
• W2039242552 creator A5035655971 @default.
• W2039242552 creator A5055716619 @default.
• W2039242552 date "1963-06-01" @default.
• W2039242552 modified "2023-10-15" @default.
• W2039242552 title "ACTIONS OF CERTAIN AMINES ON CEREBRAL CORTICAL NEURONES" @default.
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• W2039242552 doi "https://doi.org/10.1111/j.1476-5381.1963.tb01484.x" @default.
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