FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039246411> ?p ?o ?g. }

• W2039246411 endingPage "13530" @default.
• W2039246411 startingPage "13525" @default.
• W2039246411 abstract "The formalin model is widely used for evaluating the effects of analgesic compounds in laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; the first phase is thought to result from direct activation of primary afferent sensory neurons, whereas the second phase has been proposed to reflect the combined effects of afferent input and central sensitization in the dorsal horn. Here we show that formalin excites sensory neurons by directly activating TRPA1, a cation channel that plays an important role in inflammatory pain. Formalin induced robust calcium influx in cells expressing cloned or native TRPA1 channels, and these responses were attenuated by a previously undescribed TRPA1-selective antagonist. Moreover, sensory neurons from TRPA1-deficient mice lacked formalin sensitivity. At the behavioral level, pharmacologic blockade or genetic ablation of TRPA1 produced marked attenuation of the characteristic flinching, licking, and lifting responses resulting from intraplantar injection of formalin. Our results show that TRPA1 is the principal site of formalin's pain-producing action in vivo , and that activation of this excitatory channel underlies the physiological and behavioral responses associated with this model of pain hypersensitivity." @default.
• W2039246411 created "2016-06-24" @default.
• W2039246411 creator A5001964251 @default.
• W2039246411 creator A5002079697 @default.
• W2039246411 creator A5008671669 @default.
• W2039246411 creator A5012227593 @default.
• W2039246411 creator A5014886042 @default.
• W2039246411 creator A5033662116 @default.
• W2039246411 creator A5044271442 @default.
• W2039246411 creator A5046596714 @default.
• W2039246411 creator A5047802854 @default.
• W2039246411 creator A5084124205 @default.
• W2039246411 creator A5090685833 @default.
• W2039246411 date "2007-08-14" @default.
• W2039246411 modified "2023-10-18" @default.
• W2039246411 title "TRPA1 mediates formalin-induced pain" @default.
• W2039246411 cites W1980798939 @default.
• W2039246411 cites W2001933690 @default.
• W2039246411 cites W2009345240 @default.
• W2039246411 cites W2014100166 @default.
• W2039246411 cites W2014614933 @default.
• W2039246411 cites W2020595768 @default.
• W2039246411 cites W2020833052 @default.
• W2039246411 cites W2027053525 @default.
• W2039246411 cites W2032998637 @default.
• W2039246411 cites W2035257142 @default.
• W2039246411 cites W2044686423 @default.
• W2039246411 cites W2062978707 @default.
• W2039246411 cites W2066451287 @default.
• W2039246411 cites W2090734244 @default.
• W2039246411 cites W2106097986 @default.
• W2039246411 cites W2109879418 @default.
• W2039246411 cites W2120229762 @default.
• W2039246411 cites W2124339046 @default.
• W2039246411 cites W2129326126 @default.
• W2039246411 cites W2132829674 @default.
• W2039246411 cites W2146958131 @default.
• W2039246411 cites W2156733405 @default.
• W2039246411 cites W2159017711 @default.
• W2039246411 cites W2171205074 @default.
• W2039246411 cites W2278324798 @default.
• W2039246411 doi "https://doi.org/10.1073/pnas.0705924104" @default.
• W2039246411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1941642" @default.
• W2039246411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17686976" @default.
• W2039246411 hasPublicationYear "2007" @default.
• W2039246411 type Work @default.
• W2039246411 sameAs 2039246411 @default.
• W2039246411 citedByCount "1065" @default.
• W2039246411 countsByYear W20392464112012 @default.
• W2039246411 countsByYear W20392464112013 @default.
• W2039246411 countsByYear W20392464112014 @default.
• W2039246411 countsByYear W20392464112015 @default.
• W2039246411 countsByYear W20392464112016 @default.
• W2039246411 countsByYear W20392464112017 @default.
• W2039246411 countsByYear W20392464112018 @default.
• W2039246411 countsByYear W20392464112019 @default.
• W2039246411 countsByYear W20392464112020 @default.
• W2039246411 countsByYear W20392464112021 @default.
• W2039246411 countsByYear W20392464112022 @default.
• W2039246411 countsByYear W20392464112023 @default.
• W2039246411 crossrefType "journal-article" @default.
• W2039246411 hasAuthorship W2039246411A5001964251 @default.
• W2039246411 hasAuthorship W2039246411A5002079697 @default.
• W2039246411 hasAuthorship W2039246411A5008671669 @default.
• W2039246411 hasAuthorship W2039246411A5012227593 @default.
• W2039246411 hasAuthorship W2039246411A5014886042 @default.
• W2039246411 hasAuthorship W2039246411A5033662116 @default.
• W2039246411 hasAuthorship W2039246411A5044271442 @default.
• W2039246411 hasAuthorship W2039246411A5046596714 @default.
• W2039246411 hasAuthorship W2039246411A5047802854 @default.
• W2039246411 hasAuthorship W2039246411A5084124205 @default.
• W2039246411 hasAuthorship W2039246411A5090685833 @default.
• W2039246411 hasBestOaLocation W20392464111 @default.
• W2039246411 hasConcept C112592302 @default.
• W2039246411 hasConcept C126322002 @default.
• W2039246411 hasConcept C150903083 @default.
• W2039246411 hasConcept C15490471 @default.
• W2039246411 hasConcept C155164980 @default.
• W2039246411 hasConcept C169760540 @default.
• W2039246411 hasConcept C170493617 @default.
• W2039246411 hasConcept C17077164 @default.
• W2039246411 hasConcept C172659308 @default.
• W2039246411 hasConcept C185592680 @default.
• W2039246411 hasConcept C207001950 @default.
• W2039246411 hasConcept C2776032975 @default.
• W2039246411 hasConcept C2776217527 @default.
• W2039246411 hasConcept C2776281502 @default.
• W2039246411 hasConcept C2776885963 @default.
• W2039246411 hasConcept C2779245659 @default.
• W2039246411 hasConcept C2780723003 @default.
• W2039246411 hasConcept C519063684 @default.
• W2039246411 hasConcept C55493867 @default.
• W2039246411 hasConcept C71924100 @default.
• W2039246411 hasConcept C86803240 @default.
• W2039246411 hasConcept C94487597 @default.
• W2039246411 hasConcept C98274493 @default.
• W2039246411 hasConceptScore W2039246411C112592302 @default.
• W2039246411 hasConceptScore W2039246411C126322002 @default.

• next