FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039261608> ?p ?o ?g. }

• W2039261608 endingPage "746" @default.
• W2039261608 startingPage "733" @default.
• W2039261608 abstract "Locus control regions (LCRs) are defined by their ability to confer reproducible physiological levels of transgene expression in mice and therefore thought to possess the ability to generate dominantly a transcriptionally active chromatin structure. We report the first characterization of a muscle-cell-specific LCR, which is linked to the human desmin gene (DES). The DES LCR consists of five regions of muscle-specific DNase I hypersensitivity (HS) localized between -9 and -18 kb 5' of DES and reproducibly drives full physiological levels of expression in all muscle cell types. The DES LCR DNase I HS regions are highly conserved between humans and other mammals and can potentially bind a broad range of muscle-specific and ubiquitous transcription factors. Bioinformatics and direct molecular analysis show that the DES locus consists of three muscle-specific (DES) or muscle preferentially expressed genes (APEG1 and SPEG, the human orthologue of murine striated-muscle-specific serine/threonine protein kinase, Speg). The DES LCR may therefore regulate expression of SPEG and APEG1 as well as DES." @default.
• W2039261608 created "2016-06-24" @default.
• W2039261608 creator A5003109192 @default.
• W2039261608 creator A5022373311 @default.
• W2039261608 creator A5022832176 @default.
• W2039261608 creator A5035112505 @default.
• W2039261608 creator A5046261021 @default.
• W2039261608 creator A5048092079 @default.
• W2039261608 creator A5051580706 @default.
• W2039261608 creator A5055891535 @default.
• W2039261608 creator A5056347519 @default.
• W2039261608 creator A5062520767 @default.
• W2039261608 date "2006-06-01" @default.
• W2039261608 modified "2023-10-04" @default.
• W2039261608 title "The human desmin locus: Gene organization and LCR-mediated transcriptional control" @default.
• W2039261608 cites W1431639342 @default.
• W2039261608 cites W1484529414 @default.
• W2039261608 cites W1486302160 @default.
• W2039261608 cites W1533890682 @default.
• W2039261608 cites W1595583901 @default.
• W2039261608 cites W1805746022 @default.
• W2039261608 cites W1821582542 @default.
• W2039261608 cites W1966339894 @default.
• W2039261608 cites W1966794959 @default.
• W2039261608 cites W1973862215 @default.
• W2039261608 cites W1981101983 @default.
• W2039261608 cites W1982474337 @default.
• W2039261608 cites W1982498248 @default.
• W2039261608 cites W1990061796 @default.
• W2039261608 cites W1992358357 @default.
• W2039261608 cites W1997170085 @default.
• W2039261608 cites W1999909705 @default.
• W2039261608 cites W2006247010 @default.
• W2039261608 cites W2017258611 @default.
• W2039261608 cites W2021331849 @default.
• W2039261608 cites W2030629446 @default.
• W2039261608 cites W2035430192 @default.
• W2039261608 cites W2043509272 @default.
• W2039261608 cites W2059080932 @default.
• W2039261608 cites W2066638490 @default.
• W2039261608 cites W2068011423 @default.
• W2039261608 cites W2068044409 @default.
• W2039261608 cites W2070057207 @default.
• W2039261608 cites W2072606138 @default.
• W2039261608 cites W2086368962 @default.
• W2039261608 cites W2090705888 @default.
• W2039261608 cites W2092668266 @default.
• W2039261608 cites W2100108701 @default.
• W2039261608 cites W2102365433 @default.
• W2039261608 cites W2112851680 @default.
• W2039261608 cites W2117288851 @default.
• W2039261608 cites W2118704009 @default.
• W2039261608 cites W2119080072 @default.
• W2039261608 cites W2122978927 @default.
• W2039261608 cites W2125365759 @default.
• W2039261608 cites W2129159166 @default.
• W2039261608 cites W2133138033 @default.
• W2039261608 cites W2139756851 @default.
• W2039261608 cites W2141340108 @default.
• W2039261608 cites W2147933625 @default.
• W2039261608 cites W2148212953 @default.
• W2039261608 cites W2149231832 @default.
• W2039261608 cites W2150009446 @default.
• W2039261608 cites W2164547597 @default.
• W2039261608 cites W2167989032 @default.
• W2039261608 cites W2168639912 @default.
• W2039261608 cites W2171242022 @default.
• W2039261608 cites W2334152511 @default.
• W2039261608 cites W4254353414 @default.
• W2039261608 doi "https://doi.org/10.1016/j.ygeno.2006.01.009" @default.
• W2039261608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16545539" @default.
• W2039261608 hasPublicationYear "2006" @default.
• W2039261608 type Work @default.
• W2039261608 sameAs 2039261608 @default.
• W2039261608 citedByCount "19" @default.
• W2039261608 countsByYear W20392616082012 @default.
• W2039261608 countsByYear W20392616082013 @default.
• W2039261608 countsByYear W20392616082014 @default.
• W2039261608 countsByYear W20392616082015 @default.
• W2039261608 countsByYear W20392616082016 @default.
• W2039261608 countsByYear W20392616082017 @default.
• W2039261608 countsByYear W20392616082018 @default.
• W2039261608 countsByYear W20392616082020 @default.
• W2039261608 countsByYear W20392616082021 @default.
• W2039261608 countsByYear W20392616082022 @default.
• W2039261608 crossrefType "journal-article" @default.
• W2039261608 hasAuthorship W2039261608A5003109192 @default.
• W2039261608 hasAuthorship W2039261608A5022373311 @default.
• W2039261608 hasAuthorship W2039261608A5022832176 @default.
• W2039261608 hasAuthorship W2039261608A5035112505 @default.
• W2039261608 hasAuthorship W2039261608A5046261021 @default.
• W2039261608 hasAuthorship W2039261608A5048092079 @default.
• W2039261608 hasAuthorship W2039261608A5051580706 @default.
• W2039261608 hasAuthorship W2039261608A5055891535 @default.
• W2039261608 hasAuthorship W2039261608A5056347519 @default.
• W2039261608 hasAuthorship W2039261608A5062520767 @default.
• W2039261608 hasConcept C101762097 @default.
• W2039261608 hasConcept C102230213 @default.

• next