Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039261865> ?p ?o ?g. }
- W2039261865 endingPage "2759" @default.
- W2039261865 startingPage "2753" @default.
- W2039261865 abstract "X-chromosome inactivation (XCI) is the process in which females transcriptionally silence one of their two X chromosomes in early embryonic development, equalizing X chromosome gene expression between males and females. XCI depends on a gene called XIST, a functional RNA molecule that does not code for a protein. Recent studies indicate abundant intergenic transcription and nonprotein coding RNAs in the human genome, which are suspected to function in modulating gene expression. XCI may therefore serve as a useful model to learn and understand the potential function of these elements, as well as their effects on human disease. Here, we review the genetic and molecular basis of XCI and describe how the mechanistics of this process lead to the phenotypes of X-linked skin diseases, most notably in the pattern of lines, swirls, and whorls first noted by the dermatologist Alfred Blaschko. We suggest that XCI, and other epigenetic phenomena, will continue to impact our understanding of the genetic mechanisms of disease.Journal of Investigative Dermatology (2008) 128, 2753-2759; doi:10.1038/jid.2008.145; published online 29 May 2008." @default.
- W2039261865 created "2016-06-24" @default.
- W2039261865 creator A5013016915 @default.
- W2039261865 creator A5017303827 @default.
- W2039261865 date "2008-12-01" @default.
- W2039261865 modified "2023-10-17" @default.
- W2039261865 title "X-Chromosome Inactivation and Skin Disease" @default.
- W2039261865 cites W1532278399 @default.
- W2039261865 cites W1535914077 @default.
- W2039261865 cites W1629078953 @default.
- W2039261865 cites W1713385705 @default.
- W2039261865 cites W1979807834 @default.
- W2039261865 cites W1985567657 @default.
- W2039261865 cites W1986801877 @default.
- W2039261865 cites W2002259190 @default.
- W2039261865 cites W2006460442 @default.
- W2039261865 cites W2011794376 @default.
- W2039261865 cites W2014143877 @default.
- W2039261865 cites W2015766746 @default.
- W2039261865 cites W2020956187 @default.
- W2039261865 cites W2020958409 @default.
- W2039261865 cites W2036241360 @default.
- W2039261865 cites W2043688997 @default.
- W2039261865 cites W2047333953 @default.
- W2039261865 cites W2052074936 @default.
- W2039261865 cites W2052717400 @default.
- W2039261865 cites W2054661742 @default.
- W2039261865 cites W2065108572 @default.
- W2039261865 cites W2071167517 @default.
- W2039261865 cites W2072253445 @default.
- W2039261865 cites W2078028724 @default.
- W2039261865 cites W2080455379 @default.
- W2039261865 cites W2086465071 @default.
- W2039261865 cites W2091151146 @default.
- W2039261865 cites W2093533550 @default.
- W2039261865 cites W2095579742 @default.
- W2039261865 cites W2102462903 @default.
- W2039261865 cites W2106962105 @default.
- W2039261865 cites W2117626302 @default.
- W2039261865 cites W2118239133 @default.
- W2039261865 cites W2144418505 @default.
- W2039261865 cites W2156981627 @default.
- W2039261865 cites W2168334038 @default.
- W2039261865 doi "https://doi.org/10.1038/jid.2008.145" @default.
- W2039261865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18509358" @default.
- W2039261865 hasPublicationYear "2008" @default.
- W2039261865 type Work @default.
- W2039261865 sameAs 2039261865 @default.
- W2039261865 citedByCount "48" @default.
- W2039261865 countsByYear W20392618652012 @default.
- W2039261865 countsByYear W20392618652013 @default.
- W2039261865 countsByYear W20392618652014 @default.
- W2039261865 countsByYear W20392618652015 @default.
- W2039261865 countsByYear W20392618652016 @default.
- W2039261865 countsByYear W20392618652017 @default.
- W2039261865 countsByYear W20392618652018 @default.
- W2039261865 countsByYear W20392618652019 @default.
- W2039261865 countsByYear W20392618652020 @default.
- W2039261865 countsByYear W20392618652021 @default.
- W2039261865 countsByYear W20392618652022 @default.
- W2039261865 countsByYear W20392618652023 @default.
- W2039261865 crossrefType "journal-article" @default.
- W2039261865 hasAuthorship W2039261865A5013016915 @default.
- W2039261865 hasAuthorship W2039261865A5017303827 @default.
- W2039261865 hasBestOaLocation W20392618651 @default.
- W2039261865 hasConcept C104317684 @default.
- W2039261865 hasConcept C110411900 @default.
- W2039261865 hasConcept C127716648 @default.
- W2039261865 hasConcept C138885662 @default.
- W2039261865 hasConcept C142724271 @default.
- W2039261865 hasConcept C179926584 @default.
- W2039261865 hasConcept C2779134260 @default.
- W2039261865 hasConcept C35158069 @default.
- W2039261865 hasConcept C41091548 @default.
- W2039261865 hasConcept C41895202 @default.
- W2039261865 hasConcept C4323932 @default.
- W2039261865 hasConcept C54355233 @default.
- W2039261865 hasConcept C71924100 @default.
- W2039261865 hasConcept C86803240 @default.
- W2039261865 hasConceptScore W2039261865C104317684 @default.
- W2039261865 hasConceptScore W2039261865C110411900 @default.
- W2039261865 hasConceptScore W2039261865C127716648 @default.
- W2039261865 hasConceptScore W2039261865C138885662 @default.
- W2039261865 hasConceptScore W2039261865C142724271 @default.
- W2039261865 hasConceptScore W2039261865C179926584 @default.
- W2039261865 hasConceptScore W2039261865C2779134260 @default.
- W2039261865 hasConceptScore W2039261865C35158069 @default.
- W2039261865 hasConceptScore W2039261865C41091548 @default.
- W2039261865 hasConceptScore W2039261865C41895202 @default.
- W2039261865 hasConceptScore W2039261865C4323932 @default.
- W2039261865 hasConceptScore W2039261865C54355233 @default.
- W2039261865 hasConceptScore W2039261865C71924100 @default.
- W2039261865 hasConceptScore W2039261865C86803240 @default.
- W2039261865 hasIssue "12" @default.
- W2039261865 hasLocation W20392618651 @default.
- W2039261865 hasLocation W20392618652 @default.
- W2039261865 hasOpenAccess W2039261865 @default.
- W2039261865 hasPrimaryLocation W20392618651 @default.