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- W2039271100 endingPage "798" @default.
- W2039271100 startingPage "789" @default.
- W2039271100 abstract "The endoribonuclease L (RNase L) is the effector of the 2-5A system, a major enzymatic pathway involved in the molecular mechanism of interferons (IFNs). RNase L is a very unusual nuclease with a complex mechanism of regulation. It is a latent enzyme, expressed in nearly every mammalian cell type. Its activation requires its binding to a small oligonucleotide, 2-5A. 2-5A is a series of unique 5′-triphosphorylated oligoadenylates with 2′-5′ phosphodiester bonds. By regulating viral and cellular RNA expression, RNase L plays an important role in the antiviral and antiproliferative activities of IFN and contributes to innate immunity and cell metabolism. The 2-5A/RNase L pathway is implicated in mediating apoptosis in response to viral infections and to several types of external stimuli. Several recent studies have suggested that RNase L could have a role in cancer biology and evidence of a tumor suppressor function of RNase L has emerged from studies on the genetics of hereditary prostate cancer." @default.
- W2039271100 created "2016-06-24" @default.
- W2039271100 creator A5067358586 @default.
- W2039271100 creator A5073219925 @default.
- W2039271100 date "2007-06-01" @default.
- W2039271100 modified "2023-09-25" @default.
- W2039271100 title "Diverse functions of RNase L and implications in pathology" @default.
- W2039271100 cites W106733404 @default.
- W2039271100 cites W123576620 @default.
- W2039271100 cites W1481896249 @default.
- W2039271100 cites W1496120684 @default.
- W2039271100 cites W1532543449 @default.
- W2039271100 cites W1545326933 @default.
- W2039271100 cites W1550721230 @default.
- W2039271100 cites W1551309251 @default.
- W2039271100 cites W1557842650 @default.
- W2039271100 cites W1558747066 @default.
- W2039271100 cites W1563344692 @default.
- W2039271100 cites W1569936771 @default.
- W2039271100 cites W1572190823 @default.
- W2039271100 cites W1576737979 @default.
- W2039271100 cites W1576766503 @default.
- W2039271100 cites W1579443490 @default.
- W2039271100 cites W1633525445 @default.
- W2039271100 cites W166257218 @default.
- W2039271100 cites W1676562252 @default.
- W2039271100 cites W1823944837 @default.
- W2039271100 cites W1911770791 @default.
- W2039271100 cites W1929249076 @default.
- W2039271100 cites W1930219409 @default.
- W2039271100 cites W1964605210 @default.
- W2039271100 cites W1968345770 @default.
- W2039271100 cites W1969962178 @default.
- W2039271100 cites W1970480600 @default.
- W2039271100 cites W1970677867 @default.
- W2039271100 cites W1971324193 @default.
- W2039271100 cites W1972733192 @default.
- W2039271100 cites W1973458410 @default.
- W2039271100 cites W1974054239 @default.
- W2039271100 cites W1975243223 @default.
- W2039271100 cites W1981725382 @default.
- W2039271100 cites W1982419800 @default.
- W2039271100 cites W1985996776 @default.
- W2039271100 cites W1986557372 @default.
- W2039271100 cites W1990106239 @default.
- W2039271100 cites W1992614295 @default.
- W2039271100 cites W1993441524 @default.
- W2039271100 cites W1994362859 @default.
- W2039271100 cites W1994590732 @default.
- W2039271100 cites W199585338 @default.
- W2039271100 cites W1997499065 @default.
- W2039271100 cites W1998891861 @default.
- W2039271100 cites W1998985897 @default.
- W2039271100 cites W1999087217 @default.
- W2039271100 cites W1999643385 @default.
- W2039271100 cites W1999754890 @default.
- W2039271100 cites W1999867700 @default.
- W2039271100 cites W2000110844 @default.
- W2039271100 cites W2002779668 @default.
- W2039271100 cites W2010532053 @default.
- W2039271100 cites W2010630698 @default.
- W2039271100 cites W2013057753 @default.
- W2039271100 cites W2014250634 @default.
- W2039271100 cites W2018015019 @default.
- W2039271100 cites W2018071918 @default.
- W2039271100 cites W2018158124 @default.
- W2039271100 cites W2019616613 @default.
- W2039271100 cites W2021637764 @default.
- W2039271100 cites W2023289368 @default.
- W2039271100 cites W2026729363 @default.
- W2039271100 cites W2029401821 @default.
- W2039271100 cites W2030552125 @default.
- W2039271100 cites W2031256822 @default.
- W2039271100 cites W2031936012 @default.
- W2039271100 cites W2032420531 @default.
- W2039271100 cites W2032884648 @default.
- W2039271100 cites W2035488179 @default.
- W2039271100 cites W2036853011 @default.
- W2039271100 cites W2037886449 @default.
- W2039271100 cites W2039361749 @default.
- W2039271100 cites W2041169105 @default.
- W2039271100 cites W2041473192 @default.
- W2039271100 cites W2041519079 @default.
- W2039271100 cites W2041861141 @default.
- W2039271100 cites W2042191344 @default.
- W2039271100 cites W2042266259 @default.
- W2039271100 cites W2042416385 @default.
- W2039271100 cites W2043574598 @default.
- W2039271100 cites W2047502244 @default.
- W2039271100 cites W2048940551 @default.
- W2039271100 cites W2050515874 @default.
- W2039271100 cites W2053904381 @default.
- W2039271100 cites W2054243400 @default.
- W2039271100 cites W2054666300 @default.
- W2039271100 cites W2056043388 @default.
- W2039271100 cites W2056501152 @default.
- W2039271100 cites W2061925892 @default.
- W2039271100 cites W2063116879 @default.