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- W2039272475 abstract "To investigate the possible mechanisms involved in the stable and long-lasting levcromakalim-induced relaxation of the resting urethral tone, we have performed mechanical and voltage-clamp experiments using intact tissue and isolated cells from pig urethra, respectively. At negative membrane potentials, levcromakalim induced time- and voltage-independent membrane currents in whole-cell configurations. In cell-attached patches, levcromakalim not only increased the open-state probability (the NPo value) of the glibenclamide-sensitive 43 pS K+ channel (KGS) in a concentration-dependent manner, but also activated KGS with a time- and voltage-independence. During long burst-like channel activity, neither the mean open lifetime nor the mean closed time of KGS exhibited voltage-dependency between −100 and −40 mV. It is concluded that levcromakalim causes a stable and potent relaxation of pig urethra through opening of KGS which possesses time- and voltage-independent activating mechanisms." @default.
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- W2039272475 date "1999-01-01" @default.
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- W2039272475 title "Glibenclamide-sensitive K+ channels underlying levcromakalim-induced relaxation in pig urethra" @default.
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- W2039272475 doi "https://doi.org/10.1016/s0014-2999(98)00885-1" @default.
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