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• W2039284979 abstract "Exposure of human keratinocytes to UVA radiation induced an increase in ceramide (CER) intracellular content, with a dose-dependent effect within the range of 4–9 J/cm2. The production of CER reached a maximum 2 h after UVA irradiation. The increase of CER was proportional to the intracellular content of reactive oxygen species, was prevented by the antioxidant vitamin E, and enhanced by the prooxidant buthionine-sulfoximine, suggesting the involvement of an oxidative stress. UVA decreased both neutral and acid sphingomyelinase activities measured in vitro. A direct cleavage of sphingomyelin to CER by UVA, recently described, was not observed under our experimental conditions. We also show that, downstream of CER, UVA activated the Ser/Thr kinases ERK, JNK, and p38. Since ceramide has been shown to play a role in stress kinase activation, our results provide a possible mechanism for UVA-induced activation of stress kinases via ceramide formation. However, the actual mechanisms whereby CER is produced in cultured cells under UVA exposure remain to be specified." @default.
• W2039284979 created "2016-06-24" @default.
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• W2039284979 date "2001-02-01" @default.
• W2039284979 modified "2023-10-15" @default.
• W2039284979 title "UVA Radiation Stimulates Ceramide Production: Relationship to Oxidative Stress and Potential Role in ERK, JNK, and p38 Activation" @default.
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• W2039284979 doi "https://doi.org/10.1006/bbrc.2001.4348" @default.
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