Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039286502> ?p ?o ?g. }
- W2039286502 endingPage "225" @default.
- W2039286502 startingPage "215" @default.
- W2039286502 abstract "In fibroblasts and other cell types, pertussis toxin (PTX) inhibits DNA synthesis in response to serum and certain growth factors. GTPase deficient forms of the PTX-sensitive G-protein alpha i2 subunit have been shown to induce partial transformation in fibroblasts. In order to determine whether other PTX-sensitive G-proteins can stimulate mitogenic pathways, we stably expressed constitutively activated G-protein alpha i1 and alpha i3 subunits in NIH 3T3 cells. Expression of activated alpha i1, alpha i2 or alpha i3 results in inhibition of forskolin-stimulated cAMP accumulation in intact cells. Constitutively activated alpha i1, but not alpha i3, induces a loss of contact inhibition, a loss of anchorage-dependence, a reduced serum requirement and a decreased doubling time in NIH 3T3 cells. We conclude that alpha i1 and alpha i2 are both capable of transducing mitogenic signals, but that alpha i3 is not involved in the regulation of fibroblast growth. Furthermore, adenylyl cyclase inhibition is clearly not sufficient to explain the effect of alpha i2 on fibroblast growth." @default.
- W2039286502 created "2016-06-24" @default.
- W2039286502 creator A5004120768 @default.
- W2039286502 creator A5056157634 @default.
- W2039286502 creator A5066873761 @default.
- W2039286502 date "1993-03-01" @default.
- W2039286502 modified "2023-09-26" @default.
- W2039286502 title "Mitogenic effects of pertussis toxin-sensitive G-protein α subunits: The mitogenic action of αi2 in NIH 3T3 cells is mimicked by αi1, but not αi3" @default.
- W2039286502 cites W1131560862 @default.
- W2039286502 cites W1483263363 @default.
- W2039286502 cites W1489654012 @default.
- W2039286502 cites W1497932001 @default.
- W2039286502 cites W1499460529 @default.
- W2039286502 cites W1513011654 @default.
- W2039286502 cites W1513857523 @default.
- W2039286502 cites W1534335694 @default.
- W2039286502 cites W1539675729 @default.
- W2039286502 cites W1560455251 @default.
- W2039286502 cites W1587897574 @default.
- W2039286502 cites W1601533531 @default.
- W2039286502 cites W1662189542 @default.
- W2039286502 cites W1754450379 @default.
- W2039286502 cites W1927136327 @default.
- W2039286502 cites W1964265039 @default.
- W2039286502 cites W1972760976 @default.
- W2039286502 cites W1976079385 @default.
- W2039286502 cites W1977598234 @default.
- W2039286502 cites W1978834984 @default.
- W2039286502 cites W1981416199 @default.
- W2039286502 cites W1984548670 @default.
- W2039286502 cites W1990401009 @default.
- W2039286502 cites W1994152829 @default.
- W2039286502 cites W2003492314 @default.
- W2039286502 cites W2005189737 @default.
- W2039286502 cites W2017451004 @default.
- W2039286502 cites W2037305550 @default.
- W2039286502 cites W2038552415 @default.
- W2039286502 cites W2039777099 @default.
- W2039286502 cites W2046126244 @default.
- W2039286502 cites W2061334048 @default.
- W2039286502 cites W2067804507 @default.
- W2039286502 cites W2076244996 @default.
- W2039286502 cites W2078614179 @default.
- W2039286502 cites W2089393609 @default.
- W2039286502 cites W2091757239 @default.
- W2039286502 cites W2119965520 @default.
- W2039286502 cites W2149439788 @default.
- W2039286502 cites W2160392761 @default.
- W2039286502 cites W2162741613 @default.
- W2039286502 cites W2173886481 @default.
- W2039286502 cites W4293247451 @default.
- W2039286502 doi "https://doi.org/10.1016/0898-6568(93)90072-t" @default.
- W2039286502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8388703" @default.
- W2039286502 hasPublicationYear "1993" @default.
- W2039286502 type Work @default.
- W2039286502 sameAs 2039286502 @default.
- W2039286502 citedByCount "16" @default.
- W2039286502 crossrefType "journal-article" @default.
- W2039286502 hasAuthorship W2039286502A5004120768 @default.
- W2039286502 hasAuthorship W2039286502A5056157634 @default.
- W2039286502 hasAuthorship W2039286502A5066873761 @default.
- W2039286502 hasConcept C104292427 @default.
- W2039286502 hasConcept C104317684 @default.
- W2039286502 hasConcept C111798993 @default.
- W2039286502 hasConcept C121608353 @default.
- W2039286502 hasConcept C134018914 @default.
- W2039286502 hasConcept C153911025 @default.
- W2039286502 hasConcept C159110408 @default.
- W2039286502 hasConcept C161473406 @default.
- W2039286502 hasConcept C170493617 @default.
- W2039286502 hasConcept C176303035 @default.
- W2039286502 hasConcept C202751555 @default.
- W2039286502 hasConcept C2775944032 @default.
- W2039286502 hasConcept C2776746612 @default.
- W2039286502 hasConcept C2777006276 @default.
- W2039286502 hasConcept C2779178603 @default.
- W2039286502 hasConcept C2779276759 @default.
- W2039286502 hasConcept C2780381497 @default.
- W2039286502 hasConcept C49453240 @default.
- W2039286502 hasConcept C49773422 @default.
- W2039286502 hasConcept C54009773 @default.
- W2039286502 hasConcept C54355233 @default.
- W2039286502 hasConcept C55493867 @default.
- W2039286502 hasConcept C62478195 @default.
- W2039286502 hasConcept C64943373 @default.
- W2039286502 hasConcept C71924100 @default.
- W2039286502 hasConcept C80631254 @default.
- W2039286502 hasConcept C81885089 @default.
- W2039286502 hasConcept C83730767 @default.
- W2039286502 hasConcept C85771745 @default.
- W2039286502 hasConcept C86803240 @default.
- W2039286502 hasConcept C95444343 @default.
- W2039286502 hasConceptScore W2039286502C104292427 @default.
- W2039286502 hasConceptScore W2039286502C104317684 @default.
- W2039286502 hasConceptScore W2039286502C111798993 @default.
- W2039286502 hasConceptScore W2039286502C121608353 @default.
- W2039286502 hasConceptScore W2039286502C134018914 @default.
- W2039286502 hasConceptScore W2039286502C153911025 @default.