FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039292786> ?p ?o ?g. }

• W2039292786 endingPage "336" @default.
• W2039292786 startingPage "332" @default.
• W2039292786 abstract "The influence of five antibiotics (netilmicin, ceftriaxone, cefepime, fleroxacin, and ciprofloxacin) on capsular polysaccharide distribution and on opsonophagocytosis by human polymorphonuclear leukocytes of unencapsulated and encapsulated Escherichia coli strains was studied. Unencapsulated E. coli strains were readily opsonized in serum and easily ingested by polymorphonuclear leukocytes, and antibiotics did not further enhance the phagocytosis rates. In contrast, encapsulated bacteria were poorly opsonized in human serum, and phagocytosis was enhanced after overnight exposure to 0.5x the MICs of the antibiotics, with the exception of cefepime. Incubation of unencapsulated as well as encapsulated bacteria in complement-inactivated serum markedly reduced the bacterial uptake by polymorphonuclear leukocytes regardless of the presence of antibiotics. Slide agglutination assays, performed either with a monoclonal antibody for capsular polysaccharide or with an antiserum raised against the stable unencapsulated mutant E. coli O7:K-, showed reduction but not lack of the capsular polysaccharide of encapsulated E. coli O7:K1, and better exposure of subcapsular epitopes, after incubation with 0.5x the MICs of antibiotics. Flow cytometric analysis of encapsulated E. coli exposed to netilmicin, ciprofloxacin, and fleroxacin revealed that the reduction in capsular material was homogeneous among the bacterial population. Treatment with cefepime and ceftriaxone induced two populations of bacteria that differed in the amount of K antigen present. These results indicate that sub-MICs of netilmicin, ceftriaxone, fleroxacin, and ciprofloxacin influenced complement-mediated opsonization, probably due to changes in the capsular polysaccharide structure." @default.
• W2039292786 created "2016-06-24" @default.
• W2039292786 creator A5004817782 @default.
• W2039292786 creator A5013859383 @default.
• W2039292786 creator A5039813863 @default.
• W2039292786 creator A5040449963 @default.
• W2039292786 creator A5058123402 @default.
• W2039292786 creator A5065619937 @default.
• W2039292786 date "1990-02-01" @default.
• W2039292786 modified "2023-10-14" @default.
• W2039292786 title "Enhanced phagocytosis of encapsulated Escherichia coli strains after exposure to sub-MICs of antibiotics is correlated to changes of the bacterial cell surface" @default.
• W2039292786 cites W1854128845 @default.
• W2039292786 cites W1920360550 @default.
• W2039292786 cites W1962713699 @default.
• W2039292786 cites W1968020208 @default.
• W2039292786 cites W1983464826 @default.
• W2039292786 cites W1989415742 @default.
• W2039292786 cites W1991848019 @default.
• W2039292786 cites W2000559951 @default.
• W2039292786 cites W2012806226 @default.
• W2039292786 cites W2020909866 @default.
• W2039292786 cites W2022203625 @default.
• W2039292786 cites W2027598363 @default.
• W2039292786 cites W2064149030 @default.
• W2039292786 cites W2067890024 @default.
• W2039292786 cites W2094535965 @default.
• W2039292786 cites W2096501606 @default.
• W2039292786 cites W2139225802 @default.
• W2039292786 cites W2164569622 @default.
• W2039292786 cites W2171807644 @default.
• W2039292786 cites W2922060158 @default.
• W2039292786 cites W2073209045 @default.
• W2039292786 doi "https://doi.org/10.1128/aac.34.2.332" @default.
• W2039292786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/171582" @default.
• W2039292786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2109580" @default.
• W2039292786 hasPublicationYear "1990" @default.
• W2039292786 type Work @default.
• W2039292786 sameAs 2039292786 @default.
• W2039292786 citedByCount "35" @default.
• W2039292786 countsByYear W20392927862016 @default.
• W2039292786 countsByYear W20392927862019 @default.
• W2039292786 crossrefType "journal-article" @default.
• W2039292786 hasAuthorship W2039292786A5004817782 @default.
• W2039292786 hasAuthorship W2039292786A5013859383 @default.
• W2039292786 hasAuthorship W2039292786A5039813863 @default.
• W2039292786 hasAuthorship W2039292786A5040449963 @default.
• W2039292786 hasAuthorship W2039292786A5058123402 @default.
• W2039292786 hasAuthorship W2039292786A5065619937 @default.
• W2039292786 hasBestOaLocation W20392927862 @default.
• W2039292786 hasConcept C104317684 @default.
• W2039292786 hasConcept C160448771 @default.
• W2039292786 hasConcept C168507396 @default.
• W2039292786 hasConcept C2775832221 @default.
• W2039292786 hasConcept C2777050379 @default.
• W2039292786 hasConcept C2777316974 @default.
• W2039292786 hasConcept C2778049240 @default.
• W2039292786 hasConcept C2778512257 @default.
• W2039292786 hasConcept C2778974779 @default.
• W2039292786 hasConcept C2778977604 @default.
• W2039292786 hasConcept C2779631663 @default.
• W2039292786 hasConcept C2908647359 @default.
• W2039292786 hasConcept C3019249092 @default.
• W2039292786 hasConcept C501593827 @default.
• W2039292786 hasConcept C523546767 @default.
• W2039292786 hasConcept C54355233 @default.
• W2039292786 hasConcept C547475151 @default.
• W2039292786 hasConcept C55493867 @default.
• W2039292786 hasConcept C71924100 @default.
• W2039292786 hasConcept C86803240 @default.
• W2039292786 hasConcept C89372155 @default.
• W2039292786 hasConcept C89423630 @default.
• W2039292786 hasConcept C94665300 @default.
• W2039292786 hasConcept C99454951 @default.
• W2039292786 hasConceptScore W2039292786C104317684 @default.
• W2039292786 hasConceptScore W2039292786C160448771 @default.
• W2039292786 hasConceptScore W2039292786C168507396 @default.
• W2039292786 hasConceptScore W2039292786C2775832221 @default.
• W2039292786 hasConceptScore W2039292786C2777050379 @default.
• W2039292786 hasConceptScore W2039292786C2777316974 @default.
• W2039292786 hasConceptScore W2039292786C2778049240 @default.
• W2039292786 hasConceptScore W2039292786C2778512257 @default.
• W2039292786 hasConceptScore W2039292786C2778974779 @default.
• W2039292786 hasConceptScore W2039292786C2778977604 @default.
• W2039292786 hasConceptScore W2039292786C2779631663 @default.
• W2039292786 hasConceptScore W2039292786C2908647359 @default.
• W2039292786 hasConceptScore W2039292786C3019249092 @default.
• W2039292786 hasConceptScore W2039292786C501593827 @default.
• W2039292786 hasConceptScore W2039292786C523546767 @default.
• W2039292786 hasConceptScore W2039292786C54355233 @default.
• W2039292786 hasConceptScore W2039292786C547475151 @default.
• W2039292786 hasConceptScore W2039292786C55493867 @default.
• W2039292786 hasConceptScore W2039292786C71924100 @default.
• W2039292786 hasConceptScore W2039292786C86803240 @default.
• W2039292786 hasConceptScore W2039292786C89372155 @default.
• W2039292786 hasConceptScore W2039292786C89423630 @default.
• W2039292786 hasConceptScore W2039292786C94665300 @default.
• W2039292786 hasConceptScore W2039292786C99454951 @default.
• W2039292786 hasIssue "2" @default.

• next