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• W2039297713 startingPage "10792" @default.
• W2039297713 abstract "Knowledge of the molecular bases underlying the interaction of fungal pathogens with immune cells is critical to our understanding of fungal infections and offers exciting perspectives for controlling immune responses for therapy. Although fluorescence microscopy is a valuable tool to visualize pathogen–host interactions, the spatial resolution is low, meaning the fine structural details of the interacting cells cannot be observed. Here, we demonstrate the ability of correlated fluorescence-atomic force microscopy (AFM) to image the various steps of the interaction between fungal pathogens and macrophages with nanoscale resolution. We focus on Candida albicans, known to grow as two morphological forms (yeast cells, filamentous hyphae) that play important roles in modulating the interaction with macrophages. We observe the main steps of macrophage infection, including initial intercellular contact, phagocytosis by internalization of yeast cells, intracellular hyphal growth leading to mechanical stretching, and piercing of the macrophage membrane resulting in pathogen escape. While fluorescence imaging clearly distinguishes fungal cells from macrophages during the various steps of the process, AFM captures nanoscale structural features of the macrophage surface that are of high biological relevance, including ruffles, lamellipodia, filopodia, membrane remnants, and phagocytic cups. As fungal pathogenesis is mainly controlled by the ability of fungi to escape from immune cells, the nanoimaging platform established here has great potential in nanomedicine for understanding and controlling fungal infections." @default.
• W2039297713 created "2016-06-24" @default.
• W2039297713 creator A5015970740 @default.
• W2039297713 creator A5066628190 @default.
• W2039297713 date "2012-11-12" @default.
• W2039297713 modified "2023-10-16" @default.
• W2039297713 title "Nanoscale Imaging of the <i>Candida</i>–Macrophage Interaction Using Correlated Fluorescence-Atomic Force Microscopy" @default.
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• W2039297713 doi "https://doi.org/10.1021/nn304116f" @default.
• W2039297713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23146149" @default.
• W2039297713 hasPublicationYear "2012" @default.
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