FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039302017> ?p ?o ?g. }

• W2039302017 endingPage "282" @default.
• W2039302017 startingPage "273" @default.
• W2039302017 abstract "The metabolic and hemodynamic alterations in diabetes activate podocytes to increase extracellular matrix (ECM) production, leading to thickening of the glomerular basement membrane (GBM). We hypothesized that diabetes would activate parietal epithelial cells (PECs) in a similar manner and cause thickening of Bowman's capsules. Periodic acid Schiff staining of human kidney biopsies of 30 patients with diabetic nephropathy (DN) revealed a significantly thicker Bowman's capsule as compared with 20 non-diabetic controls. The average thickness was 4.55±0.21 μm in the group of patients with DN compared with 2.92±0.21 μm in the group of non-diabetic controls (P<0.001). Transmission electron microscopy confirmed this finding. In vitro, short-term exposure of human PECs to hyperglycemic conditions (30 mM glucose) advanced glycation end products (100 μg/ml) or transforming growth factor-β1 (TGF-β1; 5 ng/ml) increased the mRNA expression of collagen type I α-1, collagen type IV (all six α-chains), bamacan, nidogen 1, laminin α-1, and perlecan. Western blot and colorimetric collagen assays confirmed these results for collagen type IV at the protein level. The production and secretion of TGF-β1 as a possible positive feedback loop was excluded as a mechanism for the autocrine activation of human PECs. To validate these findings in vivo, activation of the PECs was assessed by immunohistochemical staining for CD44 of 12 human biopsy cases with DN. Thickening of the Bowman's capsule showed strong association with CD44-positive PECs. In summary, metabolic alterations in diabetes activate PECs to increase the expression and secretion of Bowman's capsule proteins. This process may contribute to the thickening of the Bowman's capsule, similar to the thickening of the GBM that is driven by activated podocytes. These data may also imply that activated PECs contribute to ECM production once they migrate to the glomerular tuft, a process resulting in glomerular scaring, for example, in diabetic glomerulosclerosis." @default.
• W2039302017 created "2016-06-24" @default.
• W2039302017 creator A5009248690 @default.
• W2039302017 creator A5057600067 @default.
• W2039302017 creator A5059066646 @default.
• W2039302017 creator A5072935760 @default.
• W2039302017 creator A5073823290 @default.
• W2039302017 creator A5084003031 @default.
• W2039302017 creator A5086146495 @default.
• W2039302017 creator A5091004058 @default.
• W2039302017 date "2015-03-01" @default.
• W2039302017 modified "2023-10-18" @default.
• W2039302017 title "Glomerular parietal epithelial cell activation induces collagen secretion and thickening of Bowman's capsule in diabetes" @default.
• W2039302017 cites W135127122 @default.
• W2039302017 cites W1483496013 @default.
• W2039302017 cites W1983244507 @default.
• W2039302017 cites W1983678974 @default.
• W2039302017 cites W1992817828 @default.
• W2039302017 cites W1994905343 @default.
• W2039302017 cites W2003993289 @default.
• W2039302017 cites W2004659869 @default.
• W2039302017 cites W2008010521 @default.
• W2039302017 cites W2011211981 @default.
• W2039302017 cites W2025991566 @default.
• W2039302017 cites W2031018955 @default.
• W2039302017 cites W2032823887 @default.
• W2039302017 cites W2033798110 @default.
• W2039302017 cites W2034909520 @default.
• W2039302017 cites W2037797688 @default.
• W2039302017 cites W2068355636 @default.
• W2039302017 cites W2079837239 @default.
• W2039302017 cites W2097942434 @default.
• W2039302017 cites W2107705756 @default.
• W2039302017 cites W2127373567 @default.
• W2039302017 cites W2136490577 @default.
• W2039302017 cites W2137061781 @default.
• W2039302017 cites W2140862356 @default.
• W2039302017 cites W2145027776 @default.
• W2039302017 cites W2148643197 @default.
• W2039302017 cites W2159126069 @default.
• W2039302017 cites W2162196137 @default.
• W2039302017 cites W2165179204 @default.
• W2039302017 cites W2417785816 @default.
• W2039302017 doi "https://doi.org/10.1038/labinvest.2014.160" @default.
• W2039302017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25531564" @default.
• W2039302017 hasPublicationYear "2015" @default.
• W2039302017 type Work @default.
• W2039302017 sameAs 2039302017 @default.
• W2039302017 citedByCount "36" @default.
• W2039302017 countsByYear W20393020172015 @default.
• W2039302017 countsByYear W20393020172016 @default.
• W2039302017 countsByYear W20393020172017 @default.
• W2039302017 countsByYear W20393020172018 @default.
• W2039302017 countsByYear W20393020172019 @default.
• W2039302017 countsByYear W20393020172020 @default.
• W2039302017 countsByYear W20393020172021 @default.
• W2039302017 countsByYear W20393020172022 @default.
• W2039302017 countsByYear W20393020172023 @default.
• W2039302017 crossrefType "journal-article" @default.
• W2039302017 hasAuthorship W2039302017A5009248690 @default.
• W2039302017 hasAuthorship W2039302017A5057600067 @default.
• W2039302017 hasAuthorship W2039302017A5059066646 @default.
• W2039302017 hasAuthorship W2039302017A5072935760 @default.
• W2039302017 hasAuthorship W2039302017A5073823290 @default.
• W2039302017 hasAuthorship W2039302017A5084003031 @default.
• W2039302017 hasAuthorship W2039302017A5086146495 @default.
• W2039302017 hasAuthorship W2039302017A5091004058 @default.
• W2039302017 hasBestOaLocation W20393020171 @default.
• W2039302017 hasConcept C105702510 @default.
• W2039302017 hasConcept C126322002 @default.
• W2039302017 hasConcept C128240485 @default.
• W2039302017 hasConcept C134018914 @default.
• W2039302017 hasConcept C170493617 @default.
• W2039302017 hasConcept C185592680 @default.
• W2039302017 hasConcept C189165786 @default.
• W2039302017 hasConcept C22731427 @default.
• W2039302017 hasConcept C2776115139 @default.
• W2039302017 hasConcept C2776193487 @default.
• W2039302017 hasConcept C2777107211 @default.
• W2039302017 hasConcept C2777146197 @default.
• W2039302017 hasConcept C2779335624 @default.
• W2039302017 hasConcept C2779561371 @default.
• W2039302017 hasConcept C2779814568 @default.
• W2039302017 hasConcept C2780091579 @default.
• W2039302017 hasConcept C2780368995 @default.
• W2039302017 hasConcept C555293320 @default.
• W2039302017 hasConcept C71924100 @default.
• W2039302017 hasConcept C86803240 @default.
• W2039302017 hasConcept C95444343 @default.
• W2039302017 hasConceptScore W2039302017C105702510 @default.
• W2039302017 hasConceptScore W2039302017C126322002 @default.
• W2039302017 hasConceptScore W2039302017C128240485 @default.
• W2039302017 hasConceptScore W2039302017C134018914 @default.
• W2039302017 hasConceptScore W2039302017C170493617 @default.
• W2039302017 hasConceptScore W2039302017C185592680 @default.
• W2039302017 hasConceptScore W2039302017C189165786 @default.
• W2039302017 hasConceptScore W2039302017C22731427 @default.
• W2039302017 hasConceptScore W2039302017C2776115139 @default.

• next