Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039317791> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2039317791 endingPage "66" @default.
- W2039317791 startingPage "60" @default.
- W2039317791 abstract "A simple and sensitive liquid chromatography-mass spectrometry (LC-MS) method was developed for the routine determination of Clarithromycin in human plasma, with Alprazolam as the internal standard. The separation was carried out on an Phenomenex (C18 100 × 4.6 mm, i.d 5 µm) column, with Acetonitrile and 10 mM Ammonium acetate Buffer solution (95:5) as the mobile phase under isocratic conditions at a flow rate of 0.2 mL/min. Detection of the analytes was achieved using positive ion electrospray tandem mass spectrometry in selected reaction monitoring (SRM) mode. The standard curves were linear (r2 > 0.99) over the concentration range of 300–5000 ng/mL. The intra- and inter-day precision (RSD) values were below 15%. The method is validated for the estimation of Clarithromycin in human plasma over a concentration range of 300–5000 ng/mL. Expected recoveries were observed. Limit of detection of the methods is 3.0 ng/ mL and limit of quantitation is 10.0 ng/mL that shows that the developed method has adequate sensitivity. The method was successfully applied to the pharmacokinetic study of Clarithromycin tablets in healthy male volunteers after oral administration." @default.
- W2039317791 created "2016-06-24" @default.
- W2039317791 creator A5058254562 @default.
- W2039317791 creator A5063238087 @default.
- W2039317791 date "2010-04-30" @default.
- W2039317791 modified "2023-09-25" @default.
- W2039317791 title "A simple and sensitive liquid chromatography–mass spectrometry routine method for determination of clarithromycin in human plasma: Application to a clinical pharmacokinetic study" @default.
- W2039317791 cites W1969983041 @default.
- W2039317791 cites W1974315684 @default.
- W2039317791 cites W1977654602 @default.
- W2039317791 cites W1978421037 @default.
- W2039317791 cites W2000636557 @default.
- W2039317791 cites W2019593323 @default.
- W2039317791 cites W2020073775 @default.
- W2039317791 cites W2025164743 @default.
- W2039317791 cites W2033635511 @default.
- W2039317791 cites W2055908131 @default.
- W2039317791 cites W2083918638 @default.
- W2039317791 cites W2093341834 @default.
- W2039317791 cites W2093934197 @default.
- W2039317791 cites W2099223133 @default.
- W2039317791 cites W2141388901 @default.
- W2039317791 cites W2132058279 @default.
- W2039317791 doi "https://doi.org/10.3109/10601331003796634" @default.
- W2039317791 hasPublicationYear "2010" @default.
- W2039317791 type Work @default.
- W2039317791 sameAs 2039317791 @default.
- W2039317791 citedByCount "0" @default.
- W2039317791 crossrefType "journal-article" @default.
- W2039317791 hasAuthorship W2039317791A5058254562 @default.
- W2039317791 hasAuthorship W2039317791A5063238087 @default.
- W2039317791 hasConcept C10390740 @default.
- W2039317791 hasConcept C112705442 @default.
- W2039317791 hasConcept C119128265 @default.
- W2039317791 hasConcept C162356407 @default.
- W2039317791 hasConcept C179998833 @default.
- W2039317791 hasConcept C185592680 @default.
- W2039317791 hasConcept C194451485 @default.
- W2039317791 hasConcept C2776962512 @default.
- W2039317791 hasConcept C2780782300 @default.
- W2039317791 hasConcept C3019249092 @default.
- W2039317791 hasConcept C31827203 @default.
- W2039317791 hasConcept C40684141 @default.
- W2039317791 hasConcept C43617362 @default.
- W2039317791 hasConcept C501593827 @default.
- W2039317791 hasConcept C55493867 @default.
- W2039317791 hasConcept C64489805 @default.
- W2039317791 hasConcept C71043704 @default.
- W2039317791 hasConcept C71924100 @default.
- W2039317791 hasConcept C98274493 @default.
- W2039317791 hasConceptScore W2039317791C10390740 @default.
- W2039317791 hasConceptScore W2039317791C112705442 @default.
- W2039317791 hasConceptScore W2039317791C119128265 @default.
- W2039317791 hasConceptScore W2039317791C162356407 @default.
- W2039317791 hasConceptScore W2039317791C179998833 @default.
- W2039317791 hasConceptScore W2039317791C185592680 @default.
- W2039317791 hasConceptScore W2039317791C194451485 @default.
- W2039317791 hasConceptScore W2039317791C2776962512 @default.
- W2039317791 hasConceptScore W2039317791C2780782300 @default.
- W2039317791 hasConceptScore W2039317791C3019249092 @default.
- W2039317791 hasConceptScore W2039317791C31827203 @default.
- W2039317791 hasConceptScore W2039317791C40684141 @default.
- W2039317791 hasConceptScore W2039317791C43617362 @default.
- W2039317791 hasConceptScore W2039317791C501593827 @default.
- W2039317791 hasConceptScore W2039317791C55493867 @default.
- W2039317791 hasConceptScore W2039317791C64489805 @default.
- W2039317791 hasConceptScore W2039317791C71043704 @default.
- W2039317791 hasConceptScore W2039317791C71924100 @default.
- W2039317791 hasConceptScore W2039317791C98274493 @default.
- W2039317791 hasIssue "2" @default.
- W2039317791 hasLocation W20393177911 @default.
- W2039317791 hasOpenAccess W2039317791 @default.
- W2039317791 hasPrimaryLocation W20393177911 @default.
- W2039317791 hasRelatedWork W1998754189 @default.
- W2039317791 hasRelatedWork W2024934348 @default.
- W2039317791 hasRelatedWork W2051654846 @default.
- W2039317791 hasRelatedWork W2055908131 @default.
- W2039317791 hasRelatedWork W2083466110 @default.
- W2039317791 hasRelatedWork W2106793718 @default.
- W2039317791 hasRelatedWork W2124309600 @default.
- W2039317791 hasRelatedWork W2972429458 @default.
- W2039317791 hasRelatedWork W3023432142 @default.
- W2039317791 hasRelatedWork W3143827393 @default.
- W2039317791 hasVolume "27" @default.
- W2039317791 isParatext "false" @default.
- W2039317791 isRetracted "false" @default.
- W2039317791 magId "2039317791" @default.
- W2039317791 workType "article" @default.