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- W2039323901 abstract "The relation between the radiosensitivity of Ehrlich ascites tumor cells and the concentration of oxygen in the medium in which the cells are suspended at the time of irradiation was determined at various temperatures and found to conform to the relation ( alpha - alpha /sub N/)/ alpha /sub N/ = (m-1) STAO/sub 2/!/(STAO/sub 2/! + K), where alpha is the coefficient of abnormal anaphase production per roentgen. The constants m and K have been evaluated at different temperatures. In experiments involving the measurement of the partial pressure of oxygen in a turbulent fluid, the equilibration of ascites tumor cell suspensions with gases of low oxygen content has been studied. Tumor cell suspensions have been irradiated at room temperature under conditions in which the partial pressure of oxygen in the liquid phase is less than that in the gas phase by no more than the equivalent of 1 mu M/l of dissolved oxygen. Under these conditions, it is estimated that m = 3.10 plus or minus 0.27 and K = 5 plus or minus 2 mu M/l. The aberration coefficients under both anaerobic and fully aerobic conditions rise by about 30% over the temperature range 3 to 30 deg C,more » but their ratio, m, remains constant, within the limits of experimental error. The small increase with temperature of individual aberration coefficients could, at least in part, be due to a different distribution with respect to phase in the mitotic cycle of the cells irradiated at different temperatures. Measurements at 36 deg C are consistent with a value of K which is the same as at 18 deg C, but uncertainty regarding the concentration of dissolved oxygen is in this case greater, and a tem perature dependence of K amounting to a factor of about 2 over this temperature range is not in any way ruled out. (auth)« less" @default.
- W2039323901 created "2016-06-24" @default.
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- W2039323901 title "Influence of Oxygen Tension on X-Ray-Induced Chromosomal Damage in Ehrlich Ascites Tumor Cells Irradiated in Vitro and in Vivo" @default.
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- W2039323901 doi "https://doi.org/10.2307/3570739" @default.
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