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- W2039328925 abstract "A large percentage of current drugs target G-protein-coupled receptors, which couple to well-known signaling pathways involving cAMP or calcium. G-proteins themselves may subserve a second messenger function. Here, we review the role of tubulin and microtubules in directly mediating effects of heterotrimeric G-proteins on neuronal outgrowth, shape and differentiation. G-protein-tubulin interactions appear to be regulated by neurotransmitter activity, and, in turn, regulate the location of Galpha in membrane microdomains (such as lipid rafts) or the cytosol. Tubulin binds with nanomolar affinity to Gsalpha, Gialpha1 and Gqalpha (but not other Galpha subunits) as well as Gbeta(1)gamma(2) subunits. Galpha subunits destabilize microtubules by stimulating tubulin's GTPase, while Gbetagamma subunits promote microtubule stability. The same region on Gsalpha that binds adenylyl cyclase and Gbetagamma also interacts with tubulin, suggesting that cytoskeletal proteins are novel Galpha effectors. Additionally, intracellular Gialpha-GDP, in concert with other GTPase proteins and Gbetagamma, regulates the position of the mitotic spindle in mitosis. Thus, G-protein activation modulates cell growth and differentiation by directly altering microtubule stability. Further studies are needed to fully establish a structural mechanism of this interaction and its role in synaptic plasticity." @default.
- W2039328925 created "2016-06-24" @default.
- W2039328925 creator A5026181487 @default.
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- W2039328925 creator A5064859821 @default.
- W2039328925 creator A5078793776 @default.
- W2039328925 date "2009-01-01" @default.
- W2039328925 modified "2023-10-14" @default.
- W2039328925 title "Heterotrimeric G-Proteins Interact Directly with Cytoskeletal Components to Modify Microtubule-Dependent Cellular Processes" @default.
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- W2039328925 doi "https://doi.org/10.1159/000186693" @default.
- W2039328925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2836952" @default.
- W2039328925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19212143" @default.
- W2039328925 hasPublicationYear "2009" @default.
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