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- W2039333722 abstract "Abstract Neocarzinostatin solubilized chromatin from rat liver nuclei in the presence of 2-mercaptoethanol with little increase in acid-soluble materials. When DNA from the chromatins was electrophoresed on neutral and alkaline agarose gels, a series of bands with a multiple of a monomeric nucleosomal unit was observed, and the ratio of double-strand to single-strand breaks of DNA in chromatin was high (1:7) as compared with findings in the case of purified DNA (1:30). Hybridization analysis of the DNAs with cDNA of liver polysomal poly(A)+mRNA revealed that neocarzinostatin solubilized a specific chromatin and which differed from the active chromatin which was preferentially excised by micrococcal nuclease." @default.
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- W2039333722 date "1982-02-01" @default.
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- W2039333722 title "Action of neocarzinostatin on cell nuclei: Release of specific chromatin" @default.
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- W2039333722 doi "https://doi.org/10.1016/0006-291x(82)91332-8" @default.
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