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- W2039338235 abstract "Since the first reports of the capacity of bone marrow stem cells for use in cardiac repair and regeneration after acute myocardial infarction, today, the therapeutic strategy of direct cell administration during cardiac surgery is entering clinical practice. Here we report on the current knowledge of the new cellular tool in the cardiac surgeon's hands that is enabling them to exceed the limits of modern methods for myocardial revascularization and repair in cardiac surgery. Therefore, we discuss preclinical data focusing on bone marrow stem cell types and point to the current mechanistic explanation of their effects. With 7 years' experience after completing Phase I and Phase II clinical trials with cardiac transplantation of autologous intramyocardial bone marrow stem cells, we draw conclusions about surgical applicability, safety, and efficacy. At present, the functional effects of this treatment are highly promising to become a standard treatment. Further clarification by prospective randomized clinical Phase III trials is necessary in this field." @default.
- W2039338235 created "2016-06-24" @default.
- W2039338235 creator A5055249856 @default.
- W2039338235 creator A5067974161 @default.
- W2039338235 date "2008-06-01" @default.
- W2039338235 modified "2023-10-16" @default.
- W2039338235 title "Current Status of Intramyocardial Bone Marrow Stem Cell Transplantation" @default.
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- W2039338235 doi "https://doi.org/10.1053/j.semtcvs.2008.03.003" @default.
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