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• W2039348718 endingPage "1967" @default.
• W2039348718 startingPage "1955" @default.
• W2039348718 abstract "Fragile X syndrome, caused by the mutation of the Fmr1 gene, is characterized by deficits of attention and learning ability. In the hippocampus of Fmr1 knockout mice (KO), long-term depression is enhanced whereas long-term potentiation (LTP) including late-phase LTP (L-LTP) is reduced or unaffected. Here we examined L-LTP in the anterior cingulate cortex (ACC) in Fmr1 KO mice by using a 64-electrode array recording system. In wild-type mice, theta-burst stimulation induced L-LTP that does not occur in all active electrodes/channels within the cingulate circuit and is typically detected in ∼75% of active channels. Furthermore, L-LTP recruited new responses from previous inactive channels. Both L-LTP and the recruitment of inactive responses were blocked in the ACC slices of Fmr1 KO mice. Bath application of metabotropic glutamate receptor 5 (mGluR5) antagonist or glycogen synthase kinase-3 (GSK3) inhibitors rescued the L-LTP and network recruitment. Our results demonstrate that loss of FMRP will greatly impair L-LTP and recruitment of cortical network in the ACC that can be rescued by pharmacological inhibition of mGluR5 or GSK3. This study is the first report of the network properties of L-LTP in the ACC, and provides basic mechanisms for future treatment of cortex-related cognitive defects in fragile X patients." @default.
• W2039348718 created "2016-06-24" @default.
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• W2039348718 date "2014-02-20" @default.
• W2039348718 modified "2023-10-17" @default.
• W2039348718 title "Pharmacological Rescue of Cortical Synaptic and Network Potentiation in a Mouse Model for Fragile X Syndrome" @default.
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• W2039348718 cites W2001197698 @default.
• W2039348718 cites W2002364516 @default.
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• W2039348718 doi "https://doi.org/10.1038/npp.2014.44" @default.
• W2039348718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4059905" @default.
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• W2039348718 hasPublicationYear "2014" @default.
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