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- W2039348730 abstract "Abstract The effects of five antidepressants, two phenothiazines and one butyrophenone neuroleptic drug on respiratory functions of rat heart mitochondria were studied in vitro using four different substrates. All compounds caused uncoupling of oxidative phosphorylation with comparable no-effect levels ranging from 1 × 10−6 to 5 × 10−5 moles per mg mitochondrial protein. The uncoupling effect was accompanied by increased oxygen consumption. The same drugs were given orally twice daily to rats. Uncoupling of oxidative phosphorylation was observed in mitochondria isolated from hearts of the treated animals. Oxygen consumption was not altered. Serum and myocardial tissue levels were determined with one of the test compounds (protriptyline). Serum concentrations in rats were higher than those observed in patients treated therapeutically, but well below those observed in human overdose situations. The effects on heart mitochondria are considered to be an indicator of altered membrane functions resulting from an accumulation of the drugs in lipid membranes." @default.
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- W2039348730 title "Effect of antidepressant and neuroleptic drugs on respiratory function of rat heart mitochondria" @default.
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- W2039348730 doi "https://doi.org/10.1016/0006-2952(79)90394-0" @default.
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