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- W2039348922 abstract "Parkinson's disease (PD) is a movement disorder characterized by a progressive loss of nigrostriatal dopaminergic neurons. Microglia activation and neuroinflammation have been associated with the pathogenesis of PD. Indeed, cytokines have been proposed as candidates that mediate the apoptotic cell death of dopaminergic neurons seen in PD. In this study, we investigated the effect of two natural polyphenols, resveratrol and quercetin, on neuroinflammation. For glial cells, we observed that lipopolysaccharide (LPS)-induced mRNA levels of two proinflammatory genes, interleukin 1-alpha and tumor necrosis factor-alpha, are strongly decreased by treatments with resveratrol or quercetin. We also undertook microglial-neuronal coculture to examine the influence of resveratrol and quercetin on dopaminergic neuronal cell death evoked by LPS-activated microglia. Cytotoxicity assays were performed to evaluate the percentage of cell death, with apoptotic cells identified by both the TdT-mediated dUTP nick end labeling technique and the detection of cleaved caspase-3. We report that treatment of N9 microglial cells with resveratrol or quercetin successfully reduced the inflammation-mediated apoptotic death of neuronal cells in our coculture system. Altogether our results demonstrate that resveratrol and quercetin diminished apoptotic neuronal cell death induced by microglial activation and suggest that these two phytoestrogens may be potent antiinflammatory compounds." @default.
- W2039348922 created "2016-06-24" @default.
- W2039348922 creator A5009389751 @default.
- W2039348922 creator A5010091165 @default.
- W2039348922 creator A5017887174 @default.
- W2039348922 date "2007-10-10" @default.
- W2039348922 modified "2023-10-09" @default.
- W2039348922 title "Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation" @default.
- W2039348922 cites W1530199299 @default.
- W2039348922 cites W1629697287 @default.
- W2039348922 cites W171118067 @default.
- W2039348922 cites W1874568289 @default.
- W2039348922 cites W1967939624 @default.
- W2039348922 cites W1968666033 @default.
- W2039348922 cites W1968998365 @default.
- W2039348922 cites W1974854661 @default.
- W2039348922 cites W1975177900 @default.
- W2039348922 cites W1977598635 @default.
- W2039348922 cites W1979501382 @default.
- W2039348922 cites W1980959448 @default.
- W2039348922 cites W1981045684 @default.
- W2039348922 cites W1981988940 @default.
- W2039348922 cites W1984128456 @default.
- W2039348922 cites W1991805788 @default.
- W2039348922 cites W1993735050 @default.
- W2039348922 cites W1994971891 @default.
- W2039348922 cites W1997326200 @default.
- W2039348922 cites W2004611188 @default.
- W2039348922 cites W2005089402 @default.
- W2039348922 cites W2008168871 @default.
- W2039348922 cites W2010807769 @default.
- W2039348922 cites W2015555425 @default.
- W2039348922 cites W2017154472 @default.
- W2039348922 cites W2017364016 @default.
- W2039348922 cites W2018351075 @default.
- W2039348922 cites W2018651845 @default.
- W2039348922 cites W2026229470 @default.
- W2039348922 cites W2026463041 @default.
- W2039348922 cites W2034993146 @default.
- W2039348922 cites W2037577786 @default.
- W2039348922 cites W2042193205 @default.
- W2039348922 cites W2046294512 @default.
- W2039348922 cites W2047357186 @default.
- W2039348922 cites W2049970571 @default.
- W2039348922 cites W2055140428 @default.
- W2039348922 cites W2055691476 @default.
- W2039348922 cites W2060787688 @default.
- W2039348922 cites W2061194161 @default.
- W2039348922 cites W2062523063 @default.
- W2039348922 cites W2062927833 @default.
- W2039348922 cites W2063249182 @default.
- W2039348922 cites W2068082089 @default.
- W2039348922 cites W2071102503 @default.
- W2039348922 cites W2071491662 @default.
- W2039348922 cites W2080258249 @default.
- W2039348922 cites W2082682346 @default.
- W2039348922 cites W2083310921 @default.
- W2039348922 cites W2085426503 @default.
- W2039348922 cites W2091849689 @default.
- W2039348922 cites W2100042702 @default.
- W2039348922 cites W2111398489 @default.
- W2039348922 cites W2116916791 @default.
- W2039348922 cites W2117442313 @default.
- W2039348922 cites W2120487488 @default.
- W2039348922 cites W2121214791 @default.
- W2039348922 cites W2122113931 @default.
- W2039348922 cites W2126619846 @default.
- W2039348922 cites W2127563454 @default.
- W2039348922 cites W2128471985 @default.
- W2039348922 cites W2136033205 @default.
- W2039348922 cites W2136232322 @default.
- W2039348922 cites W2149907219 @default.
- W2039348922 cites W2162946620 @default.
- W2039348922 cites W2165738847 @default.
- W2039348922 cites W2165807863 @default.
- W2039348922 cites W2167550154 @default.
- W2039348922 cites W2168259756 @default.
- W2039348922 cites W2497192675 @default.
- W2039348922 cites W4294309387 @default.
- W2039348922 cites W62603772 @default.
- W2039348922 doi "https://doi.org/10.1002/jnr.21503" @default.
- W2039348922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17929310" @default.
- W2039348922 hasPublicationYear "2007" @default.
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