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- W2039357143 abstract "The validity of estimating the effect of drugs on venous return by recording outflow from the cannulated left auricle (LAO) in the mechanical left ventricle method (animals are under the controlled cardiac output) was examined in 33 dogs using adrenaline (Adr). That the increase in LAO after intraaortic injection of Adr is mostly due to increase in venous return was confirmed by the following results. 1) Through th e double T-cannulae inserted into descending aorta, Adr was injected proximally (i.a.p.), distally (i.a.d.) or bidirectionally (i.a.m.) and the increase in LAO was greater in the case of i.a.d. injection (excluding cardiac action) than i.a.p. injection (including cardiac action). 2) Inc rease in LAO due to intracoronary injection of 0.25 μg/kg of Adr was only 1/12 to 1/4 of that due to i.a.m. injection of 1 μg/kg of Adr, showing that the cardiac stimulant action of Adr has minor role in increasing LAO. It is concluded that this method is one of useful methods for estimating the effect of drugs on venous return." @default.
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- W2039357143 title "Studies on the mechanical left ventricle method for estimating the effect of drugs on venous return" @default.
- W2039357143 doi "https://doi.org/10.1254/fpj.66.675" @default.
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