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- W2039363994 abstract "The organometallic precursor fac-[99mTc(OH2)3(CO)3]+ was reacted with trimethyl-bromoacetanilido-iminodiacetic acid (mebrofenin) in phosphate buffered saline (pH 7) at 70°C for 1 h to produce the complex, 99mTc(CO)3-mebrofenin, in >95% yields. High performance liquid chromatography analysis indicated the formation of a single species. In vitro studies of 99mTc(CO)3-mebrofenin showed that the complex is stable for 24 h. No decomposition or alteration of the complex was observed in the presence of excess amount of cysteine and histidine. 99mTc-mebrofenin was also prepared for comparative evaluation by the conventional method using a ready to use kit HPLC analysis of this complex showed presence of two species. Biodistribution studies in normal Swiss mice with 99mTc(CO)3-mebrofenin showed hepatobiliary clearance. However, the retention in liver was higher (13% at 1 h p.i.) as compared to that of 99mTc-mebrofenin (3.4% at 1 h p.i.). Copyright © 2003 John Wiley & Sons, Ltd." @default.
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- W2039363994 date "2003-01-01" @default.
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- W2039363994 title "Synthesis of99mTc(CO)3-mebrofenin via [99mTc(OH2)3(CO)3]+ precursor and comparative pharmacokinetics studies with99mTc-mebrofenin" @default.
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- W2039363994 doi "https://doi.org/10.1002/jlcr.704" @default.
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