FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039378889> ?p ?o ?g. }

• W2039378889 endingPage "693" @default.
• W2039378889 startingPage "689" @default.
• W2039378889 abstract "Cellular senescence both protects multicellular organisms from cancer and contributes to their ageing. The pre-eminent tumour suppressor p53 has an important role in the induction and maintenance of senescence, but how it carries out this function remains poorly understood. In addition, although increasing evidence supports the idea that metabolic changes underlie many cell-fate decisions and p53-mediated tumour suppression, few connections between metabolic enzymes and senescence have been established. Here we describe a new mechanism by which p53 links these functions. We show that p53 represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells. Both malic enzymes are important for NADPH production, lipogenesis and glutamine metabolism, but ME2 has a more profound effect. Through the inhibition of malic enzymes, p53 regulates cell metabolism and proliferation. Downregulation of ME1 and ME2 reciprocally activates p53 through distinct MDM2- and AMP-activated protein kinase-mediated mechanisms in a feed-forward manner, bolstering this pathway and enhancing p53 activation. Downregulation of ME1 and ME2 also modulates the outcome of p53 activation, leading to strong induction of senescence, but not apoptosis, whereas enforced expression of either malic enzyme suppresses senescence. Our findings define physiological functions of malic enzymes, demonstrate a positive-feedback mechanism that sustains p53 activation, and reveal a connection between metabolism and senescence mediated by p53." @default.
• W2039378889 created "2016-06-24" @default.
• W2039378889 creator A5031059368 @default.
• W2039378889 creator A5038161005 @default.
• W2039378889 creator A5056512537 @default.
• W2039378889 creator A5062750514 @default.
• W2039378889 creator A5069362481 @default.
• W2039378889 date "2013-01-01" @default.
• W2039378889 modified "2023-10-05" @default.
• W2039378889 title "Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence" @default.
• W2039378889 cites W1513261706 @default.
• W2039378889 cites W1584132731 @default.
• W2039378889 cites W1599545708 @default.
• W2039378889 cites W1964719993 @default.
• W2039378889 cites W1970924670 @default.
• W2039378889 cites W1982395176 @default.
• W2039378889 cites W2004273407 @default.
• W2039378889 cites W2015691830 @default.
• W2039378889 cites W2017784962 @default.
• W2039378889 cites W2020110583 @default.
• W2039378889 cites W2038524754 @default.
• W2039378889 cites W2038783205 @default.
• W2039378889 cites W2039453951 @default.
• W2039378889 cites W2046100445 @default.
• W2039378889 cites W2058674722 @default.
• W2039378889 cites W2080769506 @default.
• W2039378889 cites W2083190417 @default.
• W2039378889 cites W2087404852 @default.
• W2039378889 cites W2102287393 @default.
• W2039378889 cites W2104014368 @default.
• W2039378889 cites W2110934787 @default.
• W2039378889 cites W2117275311 @default.
• W2039378889 cites W2118833232 @default.
• W2039378889 cites W2133959309 @default.
• W2039378889 cites W2135151730 @default.
• W2039378889 cites W2135730738 @default.
• W2039378889 cites W2143206501 @default.
• W2039378889 cites W2144575277 @default.
• W2039378889 cites W2154799239 @default.
• W2039378889 cites W2158676604 @default.
• W2039378889 cites W2167291962 @default.
• W2039378889 cites W2170569465 @default.
• W2039378889 cites W2171352413 @default.
• W2039378889 doi "https://doi.org/10.1038/nature11776" @default.
• W2039378889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3561500" @default.
• W2039378889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23334421" @default.
• W2039378889 hasPublicationYear "2013" @default.
• W2039378889 type Work @default.
• W2039378889 sameAs 2039378889 @default.
• W2039378889 citedByCount "381" @default.
• W2039378889 countsByYear W20393788892013 @default.
• W2039378889 countsByYear W20393788892014 @default.
• W2039378889 countsByYear W20393788892015 @default.
• W2039378889 countsByYear W20393788892016 @default.
• W2039378889 countsByYear W20393788892017 @default.
• W2039378889 countsByYear W20393788892018 @default.
• W2039378889 countsByYear W20393788892019 @default.
• W2039378889 countsByYear W20393788892020 @default.
• W2039378889 countsByYear W20393788892021 @default.
• W2039378889 countsByYear W20393788892022 @default.
• W2039378889 countsByYear W20393788892023 @default.
• W2039378889 crossrefType "journal-article" @default.
• W2039378889 hasAuthorship W2039378889A5031059368 @default.
• W2039378889 hasAuthorship W2039378889A5038161005 @default.
• W2039378889 hasAuthorship W2039378889A5056512537 @default.
• W2039378889 hasAuthorship W2039378889A5062750514 @default.
• W2039378889 hasAuthorship W2039378889A5069362481 @default.
• W2039378889 hasBestOaLocation W20393788892 @default.
• W2039378889 hasConcept C104317684 @default.
• W2039378889 hasConcept C127561419 @default.
• W2039378889 hasConcept C181199279 @default.
• W2039378889 hasConcept C2776317432 @default.
• W2039378889 hasConcept C2778957662 @default.
• W2039378889 hasConcept C522857546 @default.
• W2039378889 hasConcept C55493867 @default.
• W2039378889 hasConcept C62231903 @default.
• W2039378889 hasConcept C86803240 @default.
• W2039378889 hasConcept C95444343 @default.
• W2039378889 hasConceptScore W2039378889C104317684 @default.
• W2039378889 hasConceptScore W2039378889C127561419 @default.
• W2039378889 hasConceptScore W2039378889C181199279 @default.
• W2039378889 hasConceptScore W2039378889C2776317432 @default.
• W2039378889 hasConceptScore W2039378889C2778957662 @default.
• W2039378889 hasConceptScore W2039378889C522857546 @default.
• W2039378889 hasConceptScore W2039378889C55493867 @default.
• W2039378889 hasConceptScore W2039378889C62231903 @default.
• W2039378889 hasConceptScore W2039378889C86803240 @default.
• W2039378889 hasConceptScore W2039378889C95444343 @default.
• W2039378889 hasIssue "7434" @default.
• W2039378889 hasLocation W20393788891 @default.
• W2039378889 hasLocation W20393788892 @default.
• W2039378889 hasLocation W20393788893 @default.
• W2039378889 hasLocation W20393788894 @default.
• W2039378889 hasOpenAccess W2039378889 @default.
• W2039378889 hasPrimaryLocation W20393788891 @default.
• W2039378889 hasRelatedWork W1489121595 @default.
• W2039378889 hasRelatedWork W1599186079 @default.
• W2039378889 hasRelatedWork W2003189117 @default.

• next