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• W2039387002 abstract "We hypothesized that inhibition of nitric oxide synthase (NOS) by N G -nitro-l-arginine methyl ester (l-NAME) would alleviate the inhibition of mitochondrial oxygen uptake (V̇o 2 ) by nitric oxide and result in a speeding of phase II pulmonary V̇o 2 kinetics at the onset of heavy-intensity exercise. Seven men performed square-wave transitions from unloaded cycling to a work rate requiring 40% of the difference between the gas exchange threshold and peak V̇o 2 with and without prior intravenous infusion of l-NAME (4 mg/kg in 50 ml saline over 60 min). Pulmonary gas exchange was measured breath by breath, and V̇o 2 kinetics were determined from the averaged response to two exercise bouts performed in each condition. There were no significant differences between the control (C) and l-NAME conditions (L) for baseline V̇o 2 , the duration of phase I, or the amplitude of the primary V̇o 2 response. However, the time constant of the V̇o 2 response in phase II was significantly smaller (mean ± SE: C: 25.1 ± 3.0 s; L: 21.8 ± 3.3 s; P < 0.05), and the amplitude of the V̇o 2 slow component was significantly greater (C: 240 ± 47 ml/min; L: 363 ± 24 ml/min; P < 0.05) after l-NAME infusion. These data indicate that inhibition of NOS by l-NAME results in a significant (13%) speeding of V̇o 2 kinetics and a significant increase in the amplitude of the V̇o 2 slow component in the transition to heavy-intensity cycle exercise in men. The speeding of the primary component V̇o 2 kinetics after l-NAME infusion indicates that at least part of the intrinsic inertia to oxidative metabolism at the onset of heavy-intensity exercise may result from inhibition of mitochondrial V̇o 2 by nitric oxide. The cause of the larger V̇o 2 slow-component amplitude with l-NAME requires further investigation but may be related to differences in muscle blood flow early in the rest-to-exercise transition." @default.
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• W2039387002 date "2004-03-01" @default.
• W2039387002 modified "2023-10-15" @default.
• W2039387002 title "Influence of <scp>l</scp>-NAME on pulmonary O₂ uptake kinetics during heavy-intensity cycle exercise" @default.
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• W2039387002 doi "https://doi.org/10.1152/japplphysiol.00381.2003" @default.
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