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- W2039392337 abstract "Objective To determine the frequency of antineutrophil cytoplasmic antibodies with perinuclear staining in patients with treatment-resistant left-sided ulcerative colitis. Methods We studied four groups: treatment-resistant left-sided ulcerative colitis, treatment-responsive left-sided ulcerative colitis, ulcerative colitis historical controls, and healthy control subjects. Antineotrophil cytoplasmic antibodies were detected by enzyme-linked immunosorbent assay, and positive results were confirmed by demonstration of a perinuclear staining pattern by indirect immunofluorescence assay. Results The frequency of perinuclear antineutrophil cytoplasmic antibodies was significantly greater in treatment-resistant left-sided ulcerative colitis (90&x0025;) than in treatment-responsive left-sided ulcerative colitis (62&x0025;) (P &x003D; 0.03) or in ulcerative colitis historical controls (60&x0025;). Conclusion The increased frequency of perinuclear antineutrophil cytoplasmic antibodies in treatment-resistant left-sided ulcerative colitis suggests a possible association between these antibodies and relative resistance to medical therapy in patients with ulcerative colitis. To determine the frequency of antineutrophil cytoplasmic antibodies with perinuclear staining in patients with treatment-resistant left-sided ulcerative colitis. We studied four groups: treatment-resistant left-sided ulcerative colitis, treatment-responsive left-sided ulcerative colitis, ulcerative colitis historical controls, and healthy control subjects. Antineotrophil cytoplasmic antibodies were detected by enzyme-linked immunosorbent assay, and positive results were confirmed by demonstration of a perinuclear staining pattern by indirect immunofluorescence assay. The frequency of perinuclear antineutrophil cytoplasmic antibodies was significantly greater in treatment-resistant left-sided ulcerative colitis (90&x0025;) than in treatment-responsive left-sided ulcerative colitis (62&x0025;) (P &x003D; 0.03) or in ulcerative colitis historical controls (60&x0025;). The increased frequency of perinuclear antineutrophil cytoplasmic antibodies in treatment-resistant left-sided ulcerative colitis suggests a possible association between these antibodies and relative resistance to medical therapy in patients with ulcerative colitis." @default.
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- W2039392337 date "1996-05-01" @default.
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- W2039392337 title "Association of Antineutrophil Cytoplasmic Antibodies With Resistance to Treatment of Left-Sided Ulcerative Colitis: Results of a Pilot Study" @default.
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- W2039392337 doi "https://doi.org/10.4065/71.5.431" @default.
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