FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039395810> ?p ?o ?g. }

• W2039395810 endingPage "68" @default.
• W2039395810 startingPage "61" @default.
• W2039395810 abstract "The extreme environment of space could affect microbial behavior and may increase the risk of infectious disease during spaceflight. However, the molecular genetic changes of methicillin-resistant Staphylococcus aureus (MRSA) in response to the spaceflight environment have not been fully clarified. In the present study, we determined the draft genome sequences for an ancestral S. aureus strain (LCT-SAO) isolated from a clinical sample and three derivative strains, LCT-SAS, LCT-SAM and LCT-SAG, cultured in parallel during the spaceflight Shenzhou-X, under simulated microgravity and on the ground, respectively. To evaluate the impact of short-term spaceflight on the MRSA strains, comparative genomic analysis was implemented. Genome-based mapping of toxin genes and antibiotic resistance genes confirmed that these strains have the conventional pathogenicity and resistance to drugs, as none of the strains showed significant changes in these regions after culturing in the three different environments; this result suggests that spaceflight may not change bacterial virulence or drug resistance. Thirty-nine strain-specific sequence variants (SVs) were identified throughout the genomes, and the three derivatives exhibited almost the same mutation rates. Fifty-nine percent of SVs were located in the intergenic regions of the genomes, indicating that S. aureus may have an extremely robust repair mechanism responsible for recognizing and repairing DNA replication mismatches. It is noteworthy that strain LCT-SAS, cultured in space, presented the most unique SVs (n=9) and shared the fewest SVs with LCT-SAM (n=5) and LCT-SAG (n=4). Furthermore, we identified 10 potential deletion regions and 2 potential insertion regions, with LCT-SAS appearing more fragile than other strains by this measure. These results suggest that the environment of space is inherently complicated, with multiple variables, and cannot be simulated in a simple manner. Our results represent the first analysis of nucleotide structure variation of S. aureus strains in a spaceflight environment and also provide a valuable insight for understanding the mutation strategies of MRSA on earth." @default.
• W2039395810 created "2016-06-24" @default.
• W2039395810 creator A5002188808 @default.
• W2039395810 creator A5005143509 @default.
• W2039395810 creator A5006876976 @default.
• W2039395810 creator A5018735035 @default.
• W2039395810 creator A5023948196 @default.
• W2039395810 creator A5028993654 @default.
• W2039395810 creator A5029444910 @default.
• W2039395810 creator A5063253432 @default.
• W2039395810 creator A5070568001 @default.
• W2039395810 creator A5088498091 @default.
• W2039395810 date "2015-01-01" @default.
• W2039395810 modified "2023-10-12" @default.
• W2039395810 title "Use of genome sequencing to assess nucleotide structure variation of Staphylococcus aureus strains cultured in spaceflight on Shenzhou-X, under simulated microgravity and on the ground" @default.
• W2039395810 cites W1964326294 @default.
• W2039395810 cites W1965155358 @default.
• W2039395810 cites W2020510999 @default.
• W2039395810 cites W2025225248 @default.
• W2039395810 cites W2033713984 @default.
• W2039395810 cites W2034017564 @default.
• W2039395810 cites W2038170777 @default.
• W2039395810 cites W2040041807 @default.
• W2039395810 cites W2041309650 @default.
• W2039395810 cites W2045843097 @default.
• W2039395810 cites W2052784122 @default.
• W2039395810 cites W2059819393 @default.
• W2039395810 cites W2066010919 @default.
• W2039395810 cites W2066641028 @default.
• W2039395810 cites W2066897136 @default.
• W2039395810 cites W2075291788 @default.
• W2039395810 cites W2075892592 @default.
• W2039395810 cites W2086569686 @default.
• W2039395810 cites W2092474200 @default.
• W2039395810 cites W2101213851 @default.
• W2039395810 cites W2110392562 @default.
• W2039395810 cites W2111113492 @default.
• W2039395810 cites W2112814753 @default.
• W2039395810 cites W2124960286 @default.
• W2039395810 cites W2125194704 @default.
• W2039395810 cites W2127675271 @default.
• W2039395810 cites W2133253129 @default.
• W2039395810 cites W2142513910 @default.
• W2039395810 cites W2144706728 @default.
• W2039395810 cites W2145808030 @default.
• W2039395810 cites W2149217638 @default.
• W2039395810 cites W2151183612 @default.
• W2039395810 cites W2157881732 @default.
• W2039395810 cites W2168482920 @default.
• W2039395810 cites W2168927628 @default.
• W2039395810 cites W2170367123 @default.
• W2039395810 doi "https://doi.org/10.1016/j.micres.2014.09.001" @default.
• W2039395810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25304992" @default.
• W2039395810 hasPublicationYear "2015" @default.
• W2039395810 type Work @default.
• W2039395810 sameAs 2039395810 @default.
• W2039395810 citedByCount "14" @default.
• W2039395810 countsByYear W20393958102015 @default.
• W2039395810 countsByYear W20393958102018 @default.
• W2039395810 countsByYear W20393958102019 @default.
• W2039395810 countsByYear W20393958102020 @default.
• W2039395810 countsByYear W20393958102021 @default.
• W2039395810 countsByYear W20393958102022 @default.
• W2039395810 countsByYear W20393958102023 @default.
• W2039395810 crossrefType "journal-article" @default.
• W2039395810 hasAuthorship W2039395810A5002188808 @default.
• W2039395810 hasAuthorship W2039395810A5005143509 @default.
• W2039395810 hasAuthorship W2039395810A5006876976 @default.
• W2039395810 hasAuthorship W2039395810A5018735035 @default.
• W2039395810 hasAuthorship W2039395810A5023948196 @default.
• W2039395810 hasAuthorship W2039395810A5028993654 @default.
• W2039395810 hasAuthorship W2039395810A5029444910 @default.
• W2039395810 hasAuthorship W2039395810A5063253432 @default.
• W2039395810 hasAuthorship W2039395810A5070568001 @default.
• W2039395810 hasAuthorship W2039395810A5088498091 @default.
• W2039395810 hasBestOaLocation W20393958101 @default.
• W2039395810 hasConcept C103888896 @default.
• W2039395810 hasConcept C104317684 @default.
• W2039395810 hasConcept C105702510 @default.
• W2039395810 hasConcept C127413603 @default.
• W2039395810 hasConcept C141231307 @default.
• W2039395810 hasConcept C146978453 @default.
• W2039395810 hasConcept C24432333 @default.
• W2039395810 hasConcept C2778022156 @default.
• W2039395810 hasConcept C2779489039 @default.
• W2039395810 hasConcept C523546767 @default.
• W2039395810 hasConcept C54355233 @default.
• W2039395810 hasConcept C60987743 @default.
• W2039395810 hasConcept C62130838 @default.
• W2039395810 hasConcept C86803240 @default.
• W2039395810 hasConcept C89423630 @default.
• W2039395810 hasConceptScore W2039395810C103888896 @default.
• W2039395810 hasConceptScore W2039395810C104317684 @default.
• W2039395810 hasConceptScore W2039395810C105702510 @default.
• W2039395810 hasConceptScore W2039395810C127413603 @default.
• W2039395810 hasConceptScore W2039395810C141231307 @default.
• W2039395810 hasConceptScore W2039395810C146978453 @default.
• W2039395810 hasConceptScore W2039395810C24432333 @default.

• next