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• W2039396590 abstract "Data from mammalian systems on the molecular basis of immune recognition, on the structural and functional heterogeneity of lymphocytes, and on the interactions between lymphocytes have provided guidelines for examining the lymphocyte from a phylogenetic perspective. Current information indicates that regardless of the variability of organized lymphoid tissues and the sometimes subtle diversity of immune responses in evolutionarily distant forms, the small lymphocyte has been maintained both morphologically and as an effector of immune reactivities throughout vertebrate phylogeny. Moreover, the basic properties of the mammalian lymphocytes—the discriminatory recognition of nonself plus the amplification steps that follow such a recognition event appear to be common to lymphocytes from all vertebrates. Although examples of lymphocyte heterogeneity and cellular cooperation have been reported for representative elasmobranchs, teleosts, and amphibians, the extent and nature of lymphocyte diversity remain as major unsolved problems currently being investigated by immunologists." @default.
• W2039396590 created "2016-06-24" @default.
• W2039396590 creator A5056888488 @default.
• W2039396590 date "1975-02-01" @default.
• W2039396590 modified "2023-09-23" @default.
• W2039396590 title "Phylogeny of Lymphocyte Structure and Function" @default.
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• W2039396590 doi "https://doi.org/10.1093/icb/15.1.119" @default.
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