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- W2039402710 abstract "Nucleolar size and appearance correlate with ribosome biogenesis and cellular activity. The mechanisms underlying changes in nucleolar appearance and regulation of nucleolar size that occur during differentiation and cell cycle progression are not well understood. Caenorhabditis elegans provides a good model for studying these processes because of its small size and transparent body, well-characterized cell types and lineages, and because its cells display various sizes of nucleoli. This paper details the advantages of using C. elegans to investigate features of the nucleolus during the organism's development by following dynamic changes in fibrillarin (FIB-1) in the cells of early embryos and aged worms. This paper also illustrates the involvement of the ncl-1 gene and other possible candidate genes in nucleolar-size control. Lastly, we summarize the ribosomal proteins involved in life span and innate immunity, and those homologous genes that correspond to human disorders of ribosomopathy." @default.
- W2039402710 created "2016-06-24" @default.
- W2039402710 creator A5001414258 @default.
- W2039402710 creator A5052612476 @default.
- W2039402710 creator A5054400304 @default.
- W2039402710 creator A5058807752 @default.
- W2039402710 date "2012-01-01" @default.
- W2039402710 modified "2023-10-17" @default.
- W2039402710 title "The Nucleolus of<i>Caenorhabditis elegans</i>" @default.
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- W2039402710 doi "https://doi.org/10.1155/2012/601274" @default.
- W2039402710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3345250" @default.
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- W2039402710 hasPublicationYear "2012" @default.
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