FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039408817> ?p ?o ?g. }

• W2039408817 endingPage "210" @default.
• W2039408817 startingPage "203" @default.
• W2039408817 abstract "Dopaminergic mechanisms may be involved in the regulation of aldosterone secretion in humans and in the rat. Whether these effects are indirect or are exerted directly at the adrenal level has not yet been resolved. We now report the identification of dopaminergic binding sites in the bovine adrenal zone glomerulosa using [3H]spiperone, a butyrophenone with high affinity for D2 dopamine receptors. Specific [3H]spiperone binding (defined as binding displaceable by 10 microns (+)-butaclamol) reached equilibrium within 20 minutes at 22 degrees C, was reversible, and was heat labile (60 degrees C). Binding was of high affinity and saturable with a Kd of 1.8 +/- 0.2 nM and maximal specific binding of 38 +/- 8 fmol/mg (means +/- SEM; n = 18). [3H]Spiperone binding was unaffected by coincubation with angiotensin II, adrenocorticotropic hormone, or KCl. Binding characteristics, including a dissociation constant at the nanomolar range, greater potency of the D2-agonist LY 171555 relative to the D1-agonist SKF 38393 in inhibiting [3H]spiperone binding, and lack of stimulation of cyclic adenosine 3',5'-monophosphate by dopamine (10(-4) M), were consistent with a predominantly D2-receptor. In vitro studies with collagenase-dispersed adrenal zona glomerulosa cells showed that dopamine (10(-4) M) attenuated angiotensin II-stimulated aldosterone secretion. These observations are consistent with a direct inhibitory effect of dopamine on aldosterone secretion in the adrenal zona glomerulosa." @default.
• W2039408817 created "2016-06-24" @default.
• W2039408817 creator A5042599481 @default.
• W2039408817 creator A5057050066 @default.
• W2039408817 creator A5078824728 @default.
• W2039408817 creator A5085308382 @default.
• W2039408817 date "1986-03-01" @default.
• W2039408817 modified "2023-10-15" @default.
• W2039408817 title "Dopaminergic binding and inhibitory effect in the bovine adrenal zona glomerulosa." @default.
• W2039408817 cites W1502799818 @default.
• W2039408817 cites W1504831660 @default.
• W2039408817 cites W1866904685 @default.
• W2039408817 cites W1913026589 @default.
• W2039408817 cites W1965421408 @default.
• W2039408817 cites W1966428196 @default.
• W2039408817 cites W1968505499 @default.
• W2039408817 cites W1976342482 @default.
• W2039408817 cites W1982408634 @default.
• W2039408817 cites W1985073339 @default.
• W2039408817 cites W1986621583 @default.
• W2039408817 cites W1989086130 @default.
• W2039408817 cites W1995224276 @default.
• W2039408817 cites W2000976437 @default.
• W2039408817 cites W2012697765 @default.
• W2039408817 cites W2022189418 @default.
• W2039408817 cites W202219468 @default.
• W2039408817 cites W2026208653 @default.
• W2039408817 cites W2028352736 @default.
• W2039408817 cites W2030905853 @default.
• W2039408817 cites W2031917984 @default.
• W2039408817 cites W2033412830 @default.
• W2039408817 cites W2040838821 @default.
• W2039408817 cites W2043582582 @default.
• W2039408817 cites W2043813981 @default.
• W2039408817 cites W2047171463 @default.
• W2039408817 cites W2061805224 @default.
• W2039408817 cites W2066094043 @default.
• W2039408817 cites W2069194714 @default.
• W2039408817 cites W2076234746 @default.
• W2039408817 cites W2077395171 @default.
• W2039408817 cites W2078381039 @default.
• W2039408817 cites W2087548435 @default.
• W2039408817 cites W2096473163 @default.
• W2039408817 cites W2132726429 @default.
• W2039408817 cites W2142896111 @default.
• W2039408817 cites W2167449525 @default.
• W2039408817 cites W2261194073 @default.
• W2039408817 cites W2316643017 @default.
• W2039408817 cites W2318160141 @default.
• W2039408817 cites W2470836145 @default.
• W2039408817 doi "https://doi.org/10.1161/01.hyp.8.3.203" @default.
• W2039408817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3005168" @default.
• W2039408817 hasPublicationYear "1986" @default.
• W2039408817 type Work @default.
• W2039408817 sameAs 2039408817 @default.
• W2039408817 citedByCount "12" @default.
• W2039408817 crossrefType "journal-article" @default.
• W2039408817 hasAuthorship W2039408817A5042599481 @default.
• W2039408817 hasAuthorship W2039408817A5057050066 @default.
• W2039408817 hasAuthorship W2039408817A5078824728 @default.
• W2039408817 hasAuthorship W2039408817A5085308382 @default.
• W2039408817 hasBestOaLocation W20394088171 @default.
• W2039408817 hasConcept C120069818 @default.
• W2039408817 hasConcept C126322002 @default.
• W2039408817 hasConcept C134018914 @default.
• W2039408817 hasConcept C137183658 @default.
• W2039408817 hasConcept C170493617 @default.
• W2039408817 hasConcept C185592680 @default.
• W2039408817 hasConcept C2778258207 @default.
• W2039408817 hasConcept C2778525890 @default.
• W2039408817 hasConcept C2778938600 @default.
• W2039408817 hasConcept C2780178468 @default.
• W2039408817 hasConcept C2781073084 @default.
• W2039408817 hasConcept C2908929049 @default.
• W2039408817 hasConcept C513476851 @default.
• W2039408817 hasConcept C71924100 @default.
• W2039408817 hasConcept C86803240 @default.
• W2039408817 hasConceptScore W2039408817C120069818 @default.
• W2039408817 hasConceptScore W2039408817C126322002 @default.
• W2039408817 hasConceptScore W2039408817C134018914 @default.
• W2039408817 hasConceptScore W2039408817C137183658 @default.
• W2039408817 hasConceptScore W2039408817C170493617 @default.
• W2039408817 hasConceptScore W2039408817C185592680 @default.
• W2039408817 hasConceptScore W2039408817C2778258207 @default.
• W2039408817 hasConceptScore W2039408817C2778525890 @default.
• W2039408817 hasConceptScore W2039408817C2778938600 @default.
• W2039408817 hasConceptScore W2039408817C2780178468 @default.
• W2039408817 hasConceptScore W2039408817C2781073084 @default.
• W2039408817 hasConceptScore W2039408817C2908929049 @default.
• W2039408817 hasConceptScore W2039408817C513476851 @default.
• W2039408817 hasConceptScore W2039408817C71924100 @default.
• W2039408817 hasConceptScore W2039408817C86803240 @default.
• W2039408817 hasIssue "3" @default.
• W2039408817 hasLocation W20394088171 @default.
• W2039408817 hasLocation W20394088172 @default.
• W2039408817 hasLocation W20394088173 @default.
• W2039408817 hasOpenAccess W2039408817 @default.
• W2039408817 hasPrimaryLocation W20394088171 @default.

• next