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• W2039421566 abstract "The precise contribution of IORT to the management of locally advanced and recurrent colorectal cancer (CRC) remains uncertain. We performed a systematic review and meta-analysis to assess the value of IORT in this setting. Studies published between 1965 and 2011 that reported outcomes after IORT for advanced or recurrent CRC were identified by an electronic literature search. Studies were assessed for methodological quality and design, and evaluated for technique of IORT delivery, oncological outcomes, and complications following IORT. Outcomes were analysed with fixed-effect and random-effect model meta-analyses and heterogeneity and publication bias examined. 29 studies comprising 14 prospective and 15 retrospective studies met the inclusion criteria and were assessed, yielding a total of 3003 patients. The indication for IORT was locally advanced disease in 1792 patients and locally recurrent disease in 1211 patients. Despite heterogeneity in methodology and reporting practice, IORT is principally applied for the treatment of close or positive margins. When comparative studies were evaluated, a significant effect favouring improved local control (OR 0.22; 95% CI = 0.05–0.86; p = 0.03), disease free survival (HR 0.51; 95% CI = 0.31–0.85; p = 0.009), and overall survival (HR 0.33; 95% CI = 0.2–0.54; p = 0.001) was noted with no increase in total (OR 1.13; 95% CI = 0.77–1.65; p = 0.57), urologic (OR 1.35; 95% CI = 0.84–2.82; p = 0.47), or anastomotic complications (OR 0.94; 95% CI = 0.42–2.1; p = 0.98). Increased wound complications were noted after IORT (OR 1.86; 95% CI = 1.03–3.38; p = 0.049). Despite methodological weaknesses in the studies evaluated, our results suggest that IORT may improve oncological outcomes in advanced and recurrent CRC." @default.
• W2039421566 created "2016-06-24" @default.
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• W2039421566 date "2013-03-01" @default.
• W2039421566 modified "2023-10-14" @default.
• W2039421566 title "Intraoperative radiotherapy in colorectal cancer: Systematic review and meta-analysis of techniques, long-term outcomes, and complications" @default.
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• W2039421566 cites W1963865689 @default.
• W2039421566 cites W1964878939 @default.
• W2039421566 cites W1965550940 @default.
• W2039421566 cites W1971294331 @default.
• W2039421566 cites W1973655270 @default.
• W2039421566 cites W1975866746 @default.
• W2039421566 cites W1976421266 @default.
• W2039421566 cites W1991222496 @default.
• W2039421566 cites W1992531014 @default.
• W2039421566 cites W1994210154 @default.
• W2039421566 cites W1995602322 @default.
• W2039421566 cites W1997505243 @default.
• W2039421566 cites W2000084660 @default.
• W2039421566 cites W2000931406 @default.
• W2039421566 cites W2003143824 @default.
• W2039421566 cites W2004299796 @default.
• W2039421566 cites W2007396297 @default.
• W2039421566 cites W2007458811 @default.
• W2039421566 cites W2007654119 @default.
• W2039421566 cites W2007872832 @default.
• W2039421566 cites W2015670847 @default.
• W2039421566 cites W2016091220 @default.
• W2039421566 cites W2021416608 @default.
• W2039421566 cites W2023623711 @default.
• W2039421566 cites W2028697497 @default.
• W2039421566 cites W2030803479 @default.
• W2039421566 cites W2031327905 @default.
• W2039421566 cites W2038364908 @default.
• W2039421566 cites W2040756044 @default.
• W2039421566 cites W2044968263 @default.
• W2039421566 cites W2046676971 @default.
• W2039421566 cites W2049162768 @default.
• W2039421566 cites W2049351453 @default.
• W2039421566 cites W2050234178 @default.
• W2039421566 cites W2051775822 @default.
• W2039421566 cites W2054385160 @default.
• W2039421566 cites W2058147567 @default.
• W2039421566 cites W2058703572 @default.
• W2039421566 cites W2071856006 @default.
• W2039421566 cites W2081077866 @default.
• W2039421566 cites W2083453608 @default.
• W2039421566 cites W2088095316 @default.
• W2039421566 cites W2088483854 @default.
• W2039421566 cites W2088783942 @default.
• W2039421566 cites W2103006031 @default.
• W2039421566 cites W2107328434 @default.
• W2039421566 cites W2112970335 @default.
• W2039421566 cites W2115094082 @default.
• W2039421566 cites W2115406440 @default.
• W2039421566 cites W2120776622 @default.
• W2039421566 cites W2120986439 @default.
• W2039421566 cites W2124886112 @default.
• W2039421566 cites W2125435699 @default.
• W2039421566 cites W2126930838 @default.
• W2039421566 cites W2127625516 @default.
• W2039421566 cites W2138123600 @default.
• W2039421566 cites W2139000771 @default.
• W2039421566 cites W2140282699 @default.
• W2039421566 cites W2154076862 @default.
• W2039421566 cites W2157823046 @default.
• W2039421566 cites W2160003330 @default.
• W2039421566 cites W2165693726 @default.
• W2039421566 cites W2171524637 @default.
• W2039421566 cites W2172255378 @default.
• W2039421566 cites W2276517358 @default.
• W2039421566 cites W4211147392 @default.
• W2039421566 cites W4243678738 @default.
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• W2039421566 doi "https://doi.org/10.1016/j.suronc.2012.11.001" @default.
• W2039421566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4663079" @default.
• W2039421566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23270946" @default.
• W2039421566 hasPublicationYear "2013" @default.
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