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• W2039425559 abstract "Large unitary conductance Ca2+-activated K+ channels from smooth muscle membrane were incorporated into phospholipid planar bilayers, and the blockade induced by internally and externally applied Cs+ was characterized. Internal Cs+ blockade is voltage dependent and can be explained on the basis of a Cs+ binding to a site that senses 54% of the applied voltage, with an apparent dissociation constant, Kd(0), of 70 mM. On the other hand, external Cs+ blocks the channel in micromolar amounts, and the voltage dependence of blockade is a function of Cs+ concentration. The fractional electrical distance can be as large as 1.4 at 10 mM Cs+. This last result suggests that the channel behaves as a multi-ion pore. At large negative voltages the I-V relationships in the presence of external Cs+ show an upturn, indicating relief of Cs+ block. External Cs+ blockade is relieved by increasing the internal K+ concentration, but can be enhanced by increasing the external K+. All the characteristics of external Cs+ block can be explained by a model that incorporates a knock-on of Cs+ by K+." @default.
• W2039425559 created "2016-06-24" @default.
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• W2039425559 date "1987-11-01" @default.
• W2039425559 modified "2023-09-26" @default.
• W2039425559 title "Mechanisms of Cs+ blockade in a Ca2+-activated K+ channel from smooth muscle" @default.
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• W2039425559 doi "https://doi.org/10.1016/s0006-3495(87)83265-4" @default.
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