FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039439383> ?p ?o ?g. }

• W2039439383 endingPage "158" @default.
• W2039439383 startingPage "149" @default.
• W2039439383 abstract "The goal of this work was to develop a growth factor delivery system for use in nerve regeneration that would provide localized release of beta-nerve growth factor (β-NGF) and other members of the neurotrophin family in a controlled manner. Although β-NGF does not bind heparin with high affinity, we postulated that a basic domain found at the surface of native β-NGF could interact with heparin and slow its diffusion from a heparin-containing delivery system. To test this hypothesis, we used a heparin-containing fibrin-based cell ingrowth matrix consisting of three components, namely an immobilized heparin-binding peptide, heparin and a neurotrophin with low heparin-binding affinity. The heparin-binding peptide contained a factor XIIIa substrate and was covalently cross-linked to fibrin matrices during polymerization. This cross-linked heparin-binding peptide served to immobilize heparin within the matrix, and this immobilized heparin interacted with the neurotrophin and slowed the passive release of the growth factor from the matrix. The ability of heparin-containing fibrin matrices, with a high excess of heparin-binding sites, to slow the diffusion-based release of β-NGF from fibrin matrices was measured in the absence of cells. Conditions that provided for slow diffusion-based release of β-NGF, brain-derived neurotrophic factor, and neurotrophin-3 were tested in an assay of neurite extension from dorsal root ganglia to determine the ability of the delivery system to release active growth factor. The results demonstrated that neurotrophins, interacting with fibrin matrices containing a large molar excess of heparin relative to growth factor, enhanced neurite extension by up to 100% relative to unmodified fibrin. In the absence of the delivery system, free neurotrophins within the fibrin matrix did not enhance neurite extension. The results suggest that these matrices could serve as therapeutic materials to enhance peripheral nerve regeneration through nerve guide tubes and may have more general usefulness in tissue engineering for the delivery of non-heparin-binding growth factors." @default.
• W2039439383 created "2016-06-24" @default.
• W2039439383 creator A5000647986 @default.
• W2039439383 creator A5031517705 @default.
• W2039439383 date "2000-10-01" @default.
• W2039439383 modified "2023-10-18" @default.
• W2039439383 title "Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix" @default.
• W2039439383 cites W1487175372 @default.
• W2039439383 cites W1511063261 @default.
• W2039439383 cites W1513751959 @default.
• W2039439383 cites W1877097897 @default.
• W2039439383 cites W1926705561 @default.
• W2039439383 cites W1966305146 @default.
• W2039439383 cites W1981044942 @default.
• W2039439383 cites W1985257006 @default.
• W2039439383 cites W2002848795 @default.
• W2039439383 cites W2003144438 @default.
• W2039439383 cites W2011469489 @default.
• W2039439383 cites W2012180376 @default.
• W2039439383 cites W2032717928 @default.
• W2039439383 cites W2032890398 @default.
• W2039439383 cites W2037455416 @default.
• W2039439383 cites W2037753264 @default.
• W2039439383 cites W2051466070 @default.
• W2039439383 cites W2058286067 @default.
• W2039439383 cites W2063525911 @default.
• W2039439383 cites W2064813253 @default.
• W2039439383 cites W2069909727 @default.
• W2039439383 cites W2074785038 @default.
• W2039439383 cites W2077618441 @default.
• W2039439383 cites W2078342447 @default.
• W2039439383 cites W2129250883 @default.
• W2039439383 cites W2139741471 @default.
• W2039439383 doi "https://doi.org/10.1016/s0168-3659(00)00296-0" @default.
• W2039439383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11018553" @default.
• W2039439383 hasPublicationYear "2000" @default.
• W2039439383 type Work @default.
• W2039439383 sameAs 2039439383 @default.
• W2039439383 citedByCount "401" @default.
• W2039439383 countsByYear W20394393832012 @default.
• W2039439383 countsByYear W20394393832013 @default.
• W2039439383 countsByYear W20394393832014 @default.
• W2039439383 countsByYear W20394393832015 @default.
• W2039439383 countsByYear W20394393832016 @default.
• W2039439383 countsByYear W20394393832017 @default.
• W2039439383 countsByYear W20394393832018 @default.
• W2039439383 countsByYear W20394393832019 @default.
• W2039439383 countsByYear W20394393832020 @default.
• W2039439383 countsByYear W20394393832021 @default.
• W2039439383 countsByYear W20394393832022 @default.
• W2039439383 countsByYear W20394393832023 @default.
• W2039439383 crossrefType "journal-article" @default.
• W2039439383 hasAuthorship W2039439383A5000647986 @default.
• W2039439383 hasAuthorship W2039439383A5031517705 @default.
• W2039439383 hasConcept C12554922 @default.
• W2039439383 hasConcept C170493617 @default.
• W2039439383 hasConcept C185592680 @default.
• W2039439383 hasConcept C203014093 @default.
• W2039439383 hasConcept C2775960820 @default.
• W2039439383 hasConcept C2777557582 @default.
• W2039439383 hasConcept C2778423431 @default.
• W2039439383 hasConcept C2779036427 @default.
• W2039439383 hasConcept C2911038020 @default.
• W2039439383 hasConcept C54173615 @default.
• W2039439383 hasConcept C55493867 @default.
• W2039439383 hasConcept C86803240 @default.
• W2039439383 hasConcept C92020748 @default.
• W2039439383 hasConcept C95444343 @default.
• W2039439383 hasConceptScore W2039439383C12554922 @default.
• W2039439383 hasConceptScore W2039439383C170493617 @default.
• W2039439383 hasConceptScore W2039439383C185592680 @default.
• W2039439383 hasConceptScore W2039439383C203014093 @default.
• W2039439383 hasConceptScore W2039439383C2775960820 @default.
• W2039439383 hasConceptScore W2039439383C2777557582 @default.
• W2039439383 hasConceptScore W2039439383C2778423431 @default.
• W2039439383 hasConceptScore W2039439383C2779036427 @default.
• W2039439383 hasConceptScore W2039439383C2911038020 @default.
• W2039439383 hasConceptScore W2039439383C54173615 @default.
• W2039439383 hasConceptScore W2039439383C55493867 @default.
• W2039439383 hasConceptScore W2039439383C86803240 @default.
• W2039439383 hasConceptScore W2039439383C92020748 @default.
• W2039439383 hasConceptScore W2039439383C95444343 @default.
• W2039439383 hasIssue "1" @default.
• W2039439383 hasLocation W20394393831 @default.
• W2039439383 hasLocation W20394393832 @default.
• W2039439383 hasOpenAccess W2039439383 @default.
• W2039439383 hasPrimaryLocation W20394393831 @default.
• W2039439383 hasRelatedWork W1146534089 @default.
• W2039439383 hasRelatedWork W1856146912 @default.
• W2039439383 hasRelatedWork W1976268192 @default.
• W2039439383 hasRelatedWork W2008230694 @default.
• W2039439383 hasRelatedWork W2066217822 @default.
• W2039439383 hasRelatedWork W2331480780 @default.
• W2039439383 hasRelatedWork W2473676894 @default.
• W2039439383 hasRelatedWork W3005174885 @default.
• W2039439383 hasRelatedWork W3146891169 @default.
• W2039439383 hasRelatedWork W4295154367 @default.
• W2039439383 hasVolume "69" @default.

• next