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• W2039441002 endingPage "e66427" @default.
• W2039441002 startingPage "e66427" @default.
• W2039441002 abstract "The catalogues of protein kinases, the essential effectors of cellular signaling, have been charted in Metazoan genomes for a decade now. Yet, surprisingly, using bioinformatics tools, we predicted protein kinase structure for proteins coded by five related human genes and their Metazoan homologues, the FAM69 family. Analysis of three-dimensional structure models and conservation of the classic catalytic motifs of protein kinases present in four out of five human FAM69 proteins suggests they might have retained catalytic phosphotransferase activity. An EF-hand Ca(2+)-binding domain in FAM69A and FAM69B proteins, inserted within the structure of the kinase domain, suggests they may function as Ca(2+)-dependent kinases. The FAM69 genes, FAM69A, FAM69B, FAM69C, C3ORF58 (DIA1) and CXORF36 (DIA1R), are by large uncharacterised molecularly, yet linked to several neurological disorders in genetics studies. The C3ORF58 gene is found deleted in autism, and resides in the Golgi. Unusually high cysteine content and presence of signal peptides in some of the family members suggest that FAM69 proteins may be involved in phosphorylation of proteins in the secretory pathway and/or of extracellular proteins." @default.
• W2039441002 created "2016-06-24" @default.
• W2039441002 creator A5072526330 @default.
• W2039441002 creator A5077931336 @default.
• W2039441002 creator A5088765826 @default.
• W2039441002 date "2013-06-28" @default.
• W2039441002 modified "2023-10-13" @default.
• W2039441002 title "A Novel Predicted Calcium-Regulated Kinase Family Implicated in Neurological Disorders" @default.
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• W2039441002 doi "https://doi.org/10.1371/journal.pone.0066427" @default.
• W2039441002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3696010" @default.
• W2039441002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23840464" @default.
• W2039441002 hasPublicationYear "2013" @default.
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