FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039441880> ?p ?o ?g. }

• W2039441880 endingPage "7403" @default.
• W2039441880 startingPage "7393" @default.
• W2039441880 abstract "In eukaryotic cells, replication past damaged sites in DNA is regulated by the ubiquitination of proliferating cell nuclear antigen (PCNA). Little is known about how this process is affected by chromatin structure. There are two isoforms of the Remodels the Structure of Chromatin (RSC) remodelling complex in yeast. We show that deletion of RSC2 results in a dramatic reduction in the level of PCNA ubiquitination after DNA-damaging treatments, whereas no such effect was observed after deletion of RSC1. Similarly, depletion of the BAF180 component of the corresponding PBAF (Polybromo BRG1 (Brahma-Related Gene 1) Associated Factor) complex in human cells led to a similar reduction in PCNA ubiquitination. Remarkably, we found that depletion of BAF180 resulted after UV-irradiation, in a reduction not only of ubiquitinated PCNA but also of chromatin-associated unmodified PCNA and Rad18 (the E3 ligase that ubiquitinates PCNA). This was accompanied by a modest decrease in fork progression. We propose a model to account for these findings that postulates an involvement of PBAF in repriming of replication downstream from replication forks blocked at sites of DNA damage. In support of this model, chromatin immunoprecipitation data show that the RSC complex in yeast is present in the vicinity of the replication forks, and by extrapolation, this is also likely to be the case for the PBAF complex in human cells." @default.
• W2039441880 created "2016-06-24" @default.
• W2039441880 creator A5007478113 @default.
• W2039441880 creator A5011775119 @default.
• W2039441880 creator A5019482354 @default.
• W2039441880 creator A5048471316 @default.
• W2039441880 date "2012-05-25" @default.
• W2039441880 modified "2023-09-25" @default.
• W2039441880 title "A role for chromatin remodellers in replication of damaged DNA" @default.
• W2039441880 cites W1840855988 @default.
• W2039441880 cites W1867451140 @default.
• W2039441880 cites W1965011585 @default.
• W2039441880 cites W1974795717 @default.
• W2039441880 cites W1974875206 @default.
• W2039441880 cites W1976320739 @default.
• W2039441880 cites W1981429455 @default.
• W2039441880 cites W1984320346 @default.
• W2039441880 cites W1985746590 @default.
• W2039441880 cites W1991626728 @default.
• W2039441880 cites W1994502400 @default.
• W2039441880 cites W1995586000 @default.
• W2039441880 cites W2001891149 @default.
• W2039441880 cites W2003928652 @default.
• W2039441880 cites W2019025864 @default.
• W2039441880 cites W2022093187 @default.
• W2039441880 cites W2033346972 @default.
• W2039441880 cites W2034195501 @default.
• W2039441880 cites W2036347938 @default.
• W2039441880 cites W2036477200 @default.
• W2039441880 cites W2042488015 @default.
• W2039441880 cites W2046702833 @default.
• W2039441880 cites W2047824377 @default.
• W2039441880 cites W2054918042 @default.
• W2039441880 cites W2059788298 @default.
• W2039441880 cites W2064809185 @default.
• W2039441880 cites W2065626377 @default.
• W2039441880 cites W2069281865 @default.
• W2039441880 cites W2070494924 @default.
• W2039441880 cites W2075662557 @default.
• W2039441880 cites W2078167546 @default.
• W2039441880 cites W2079198418 @default.
• W2039441880 cites W2080574942 @default.
• W2039441880 cites W2081705690 @default.
• W2039441880 cites W2085340666 @default.
• W2039441880 cites W2085866527 @default.
• W2039441880 cites W2099367992 @default.
• W2039441880 cites W2101940270 @default.
• W2039441880 cites W2102273403 @default.
• W2039441880 cites W2102604046 @default.
• W2039441880 cites W2106466938 @default.
• W2039441880 cites W2107747328 @default.
• W2039441880 cites W2111159182 @default.
• W2039441880 cites W2115494288 @default.
• W2039441880 cites W2119301405 @default.
• W2039441880 cites W2122526183 @default.
• W2039441880 cites W2128987469 @default.
• W2039441880 cites W2137319555 @default.
• W2039441880 cites W2147524392 @default.
• W2039441880 cites W2147966104 @default.
• W2039441880 cites W2156419287 @default.
• W2039441880 cites W2157422720 @default.
• W2039441880 cites W2159956396 @default.
• W2039441880 cites W2165361375 @default.
• W2039441880 cites W2168806722 @default.
• W2039441880 cites W2169950973 @default.
• W2039441880 doi "https://doi.org/10.1093/nar/gks453" @default.
• W2039441880 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3424576" @default.
• W2039441880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22638582" @default.
• W2039441880 hasPublicationYear "2012" @default.
• W2039441880 type Work @default.
• W2039441880 sameAs 2039441880 @default.
• W2039441880 citedByCount "48" @default.
• W2039441880 countsByYear W20394418802013 @default.
• W2039441880 countsByYear W20394418802014 @default.
• W2039441880 countsByYear W20394418802015 @default.
• W2039441880 countsByYear W20394418802016 @default.
• W2039441880 countsByYear W20394418802017 @default.
• W2039441880 countsByYear W20394418802018 @default.
• W2039441880 countsByYear W20394418802019 @default.
• W2039441880 countsByYear W20394418802020 @default.
• W2039441880 countsByYear W20394418802021 @default.
• W2039441880 countsByYear W20394418802022 @default.
• W2039441880 countsByYear W20394418802023 @default.
• W2039441880 crossrefType "journal-article" @default.
• W2039441880 hasAuthorship W2039441880A5007478113 @default.
• W2039441880 hasAuthorship W2039441880A5011775119 @default.
• W2039441880 hasAuthorship W2039441880A5019482354 @default.
• W2039441880 hasAuthorship W2039441880A5048471316 @default.
• W2039441880 hasBestOaLocation W20394418801 @default.
• W2039441880 hasConcept C101762097 @default.
• W2039441880 hasConcept C104317684 @default.
• W2039441880 hasConcept C104690221 @default.
• W2039441880 hasConcept C134320426 @default.
• W2039441880 hasConcept C134935766 @default.
• W2039441880 hasConcept C143425029 @default.
• W2039441880 hasConcept C14519417 @default.
• W2039441880 hasConcept C150194340 @default.
• W2039441880 hasConcept C153911025 @default.

• next