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- W2039447515 abstract "Experimental design and response surface modeling of retention behavior were employed to optimize the reversed-phase high-performance liquid chromatographic separation of chlorpromazine and thirteen biological metabolites. A single-factor screening design and window diagram identified a region of mobile phase pH yielding the best relative retention for the worst separated pair of peaks. The effects of three mobile phase factors (pH, methylamine concentration and methanol concentration) were evaluated by a factorial design and modeled by regression analysis. Chromatographic conditions were then selected on the basis of relative retention, peak symmetry and retention time using a series of pseudo-three-dimensional window diagrams." @default.
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- W2039447515 date "1989-12-01" @default.
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- W2039447515 title "Computer-assisted optimization of a high-performance liquid chromatographic separation for chlorpromazine and thirteen metabolites" @default.
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- W2039447515 doi "https://doi.org/10.1016/s0021-9673(01)89165-2" @default.
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