FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039451386> ?p ?o ?g. }

• W2039451386 endingPage "1041" @default.
• W2039451386 startingPage "1032" @default.
• W2039451386 abstract "We recently reported the biological activity and some of the biochemical characteristics of a factor produced by a human T cell hybrid clone able to block hematopoietic progenitor cell proliferation. This 85-kD protein factor, which we have termed colony-inhibiting lymphokine (CIL), has growth regulatory activity on bone marrow precursors bearing Ia (class II) antigens of either granulocytic-monocytic (CFU-GM) or erythroid lineage (BFU-E and CFU-E). Experiments aimed to investigate the specificity of the inhibitory effect on hematopoietic progenitor cell growth suggested that the expression of HLA-DR surface antigens was required on the target cells. We describe in this communication how DR+ cell lines ceased dividing after a few days of culture in the presence of CIL, whereas DR- cell lines were completely unaffected. The increased DR expression on the ML3 cell surface, mediated by the activity of the gamma interferon (IFN gamma), increases the sensitivity to the growth inhibition factor of the ML3 cell line. To verify the hypothesis that the DR antigens might serve as receptors for the factor, enabling it also to interfere in the immune response, we tested CIL in a mixed lymphocyte reaction (MLR), one of the best known in vitro Ia antigen-dependent T cell-mediated immune responses. CIL is able to block major histocompatibility complex-allogeneic MLR both in human and mouse systems. The data indicate that CIL recognizes a nonpolymorphic structure (presumably on all Ia molecules) presented by stimulator cells of either species, and thereby interferes with specific interactions between stimulator and responder cells. Blocking of the alloantigen stimulation stage is also indicated, since CIL is effective only if added to the culture medium during the first 48 h of the MLR. Finally, mouse monoclonal anti-DR antibodies are able to sharply reduce CIL activity on sensitive DR+ cell lines. CIL may act physiologically as a multifunctional mediator in a complex network that links regulation of bone marrow differentiation and the generation of immune responses." @default.
• W2039451386 created "2016-06-24" @default.
• W2039451386 creator A5017682705 @default.
• W2039451386 creator A5045239840 @default.
• W2039451386 creator A5075546738 @default.
• W2039451386 date "1985-09-01" @default.
• W2039451386 modified "2023-10-09" @default.
• W2039451386 title "Inhibitory effect of a human T cell hybrid factor on both cell growth and mixed lymphocyte reactivity. Correlation with class II molecule expression." @default.
• W2039451386 cites W1524801043 @default.
• W2039451386 cites W1891016071 @default.
• W2039451386 cites W1927697103 @default.
• W2039451386 cites W1964643098 @default.
• W2039451386 cites W1994139317 @default.
• W2039451386 cites W1996249519 @default.
• W2039451386 cites W2008557815 @default.
• W2039451386 cites W2010566496 @default.
• W2039451386 cites W2029579492 @default.
• W2039451386 cites W2035460098 @default.
• W2039451386 cites W2038891519 @default.
• W2039451386 cites W2066435027 @default.
• W2039451386 cites W2069978012 @default.
• W2039451386 cites W2085662422 @default.
• W2039451386 cites W2094717710 @default.
• W2039451386 cites W2101391649 @default.
• W2039451386 cites W2105755716 @default.
• W2039451386 cites W211260929 @default.
• W2039451386 cites W2117631310 @default.
• W2039451386 cites W2120923915 @default.
• W2039451386 cites W2145387307 @default.
• W2039451386 cites W2154037033 @default.
• W2039451386 cites W2237078678 @default.
• W2039451386 cites W2305959659 @default.
• W2039451386 cites W2343364099 @default.
• W2039451386 cites W2408897729 @default.
• W2039451386 cites W2410635358 @default.
• W2039451386 cites W2412126959 @default.
• W2039451386 cites W262059328 @default.
• W2039451386 cites W2740180047 @default.
• W2039451386 cites W310554642 @default.
• W2039451386 cites W340685049 @default.
• W2039451386 doi "https://doi.org/10.1172/jci112056" @default.
• W2039451386 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/423978" @default.
• W2039451386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2931451" @default.
• W2039451386 hasPublicationYear "1985" @default.
• W2039451386 type Work @default.
• W2039451386 sameAs 2039451386 @default.
• W2039451386 citedByCount "3" @default.
• W2039451386 crossrefType "journal-article" @default.
• W2039451386 hasAuthorship W2039451386A5017682705 @default.
• W2039451386 hasAuthorship W2039451386A5045239840 @default.
• W2039451386 hasAuthorship W2039451386A5075546738 @default.
• W2039451386 hasBestOaLocation W20394513861 @default.
• W2039451386 hasConcept C104317684 @default.
• W2039451386 hasConcept C109159458 @default.
• W2039451386 hasConcept C147483822 @default.
• W2039451386 hasConcept C153911025 @default.
• W2039451386 hasConcept C170493617 @default.
• W2039451386 hasConcept C188280979 @default.
• W2039451386 hasConcept C201750760 @default.
• W2039451386 hasConcept C2022786 @default.
• W2039451386 hasConcept C203014093 @default.
• W2039451386 hasConcept C207936829 @default.
• W2039451386 hasConcept C2775960820 @default.
• W2039451386 hasConcept C2776090121 @default.
• W2039451386 hasConcept C2778740727 @default.
• W2039451386 hasConcept C28328180 @default.
• W2039451386 hasConcept C49382859 @default.
• W2039451386 hasConcept C54355233 @default.
• W2039451386 hasConcept C55493867 @default.
• W2039451386 hasConcept C81089528 @default.
• W2039451386 hasConcept C81885089 @default.
• W2039451386 hasConcept C86803240 @default.
• W2039451386 hasConcept C8891405 @default.
• W2039451386 hasConcept C95444343 @default.
• W2039451386 hasConceptScore W2039451386C104317684 @default.
• W2039451386 hasConceptScore W2039451386C109159458 @default.
• W2039451386 hasConceptScore W2039451386C147483822 @default.
• W2039451386 hasConceptScore W2039451386C153911025 @default.
• W2039451386 hasConceptScore W2039451386C170493617 @default.
• W2039451386 hasConceptScore W2039451386C188280979 @default.
• W2039451386 hasConceptScore W2039451386C201750760 @default.
• W2039451386 hasConceptScore W2039451386C2022786 @default.
• W2039451386 hasConceptScore W2039451386C203014093 @default.
• W2039451386 hasConceptScore W2039451386C207936829 @default.
• W2039451386 hasConceptScore W2039451386C2775960820 @default.
• W2039451386 hasConceptScore W2039451386C2776090121 @default.
• W2039451386 hasConceptScore W2039451386C2778740727 @default.
• W2039451386 hasConceptScore W2039451386C28328180 @default.
• W2039451386 hasConceptScore W2039451386C49382859 @default.
• W2039451386 hasConceptScore W2039451386C54355233 @default.
• W2039451386 hasConceptScore W2039451386C55493867 @default.
• W2039451386 hasConceptScore W2039451386C81089528 @default.
• W2039451386 hasConceptScore W2039451386C81885089 @default.
• W2039451386 hasConceptScore W2039451386C86803240 @default.
• W2039451386 hasConceptScore W2039451386C8891405 @default.
• W2039451386 hasConceptScore W2039451386C95444343 @default.
• W2039451386 hasIssue "3" @default.
• W2039451386 hasLocation W20394513861 @default.

• next