FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039452519> ?p ?o ?g. }

• W2039452519 abstract "Abstract Background SNAT1 is a subtype of the amino acid transport system A that has been implicated to play a potential role in cancer development and progression, yet its role in breast cancer remains unclear. In present study, we detected SNAT1 expression in breast cancers and explored its underlying mechanism in promoting breast carcinogenesis. Methods RT-PCR and Western blotting were performed to analyze the transcription and protein levels of SNAT1 in breast cancer cell lines and fresh tissues. Tissue microarray blocks containing breast cancer specimens obtained from 210 patients were constructed. Expression of SNAT1 in these specimens was analyzed using immunohistochemical studies. SNAT1 was down-regulated by SNAT1-shRNA in breast cancer cells and the functional significance was measured. Results SNAT1 was up-regulated in breast cancer cell lines and breast cancer tissues. Overexpression of SNAT1 was observed in 127 cases (60.5%). Expression of SNAT1 was significantly associated with tumor size, nodal metastasis, advanced disease stage, Ki-67, and ER status. Suppression of endogenous SNAT1 leads to cell growth inhibition, cell cycle arrest, and apoptosis of 4T1 cells and lowered the phosphorylation level of Akt. SNAT1 expression correlated significantly with p-Akt expression in human breast cancer samples. Conclusions The cross-talk between Akt signaling and SNAT1 might play a critical role in the development and progression of breast cancer, providing an important molecular basis for novel diagnostic markers and new attractive targets in the treatment of breast cancer patients." @default.
• W2039452519 created "2016-06-24" @default.
• W2039452519 creator A5000223213 @default.
• W2039452519 creator A5005864766 @default.
• W2039452519 creator A5044454984 @default.
• W2039452519 creator A5053787222 @default.
• W2039452519 creator A5058711314 @default.
• W2039452519 creator A5067292571 @default.
• W2039452519 creator A5078941517 @default.
• W2039452519 date "2013-07-12" @default.
• W2039452519 modified "2023-10-13" @default.
• W2039452519 title "Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression" @default.
• W2039452519 cites W1567389274 @default.
• W2039452519 cites W1708690454 @default.
• W2039452519 cites W1965993324 @default.
• W2039452519 cites W1967002030 @default.
• W2039452519 cites W1982575342 @default.
• W2039452519 cites W1985453548 @default.
• W2039452519 cites W1986868498 @default.
• W2039452519 cites W1998480684 @default.
• W2039452519 cites W1999946965 @default.
• W2039452519 cites W2018879809 @default.
• W2039452519 cites W2025977606 @default.
• W2039452519 cites W2029866449 @default.
• W2039452519 cites W2029882446 @default.
• W2039452519 cites W2041118914 @default.
• W2039452519 cites W2043310346 @default.
• W2039452519 cites W2069057214 @default.
• W2039452519 cites W2077283526 @default.
• W2039452519 cites W2090631044 @default.
• W2039452519 cites W2096401922 @default.
• W2039452519 cites W2106787323 @default.
• W2039452519 cites W2138687471 @default.
• W2039452519 cites W2151952736 @default.
• W2039452519 cites W2164509931 @default.
• W2039452519 doi "https://doi.org/10.1186/1471-2407-13-343" @default.
• W2039452519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3729721" @default.
• W2039452519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23848995" @default.
• W2039452519 hasPublicationYear "2013" @default.
• W2039452519 type Work @default.
• W2039452519 sameAs 2039452519 @default.
• W2039452519 citedByCount "44" @default.
• W2039452519 countsByYear W20394525192013 @default.
• W2039452519 countsByYear W20394525192014 @default.
• W2039452519 countsByYear W20394525192015 @default.
• W2039452519 countsByYear W20394525192016 @default.
• W2039452519 countsByYear W20394525192017 @default.
• W2039452519 countsByYear W20394525192018 @default.
• W2039452519 countsByYear W20394525192019 @default.
• W2039452519 countsByYear W20394525192020 @default.
• W2039452519 countsByYear W20394525192021 @default.
• W2039452519 countsByYear W20394525192022 @default.
• W2039452519 countsByYear W20394525192023 @default.
• W2039452519 crossrefType "journal-article" @default.
• W2039452519 hasAuthorship W2039452519A5000223213 @default.
• W2039452519 hasAuthorship W2039452519A5005864766 @default.
• W2039452519 hasAuthorship W2039452519A5044454984 @default.
• W2039452519 hasAuthorship W2039452519A5053787222 @default.
• W2039452519 hasAuthorship W2039452519A5058711314 @default.
• W2039452519 hasAuthorship W2039452519A5067292571 @default.
• W2039452519 hasAuthorship W2039452519A5078941517 @default.
• W2039452519 hasBestOaLocation W20394525191 @default.
• W2039452519 hasConcept C121608353 @default.
• W2039452519 hasConcept C126322002 @default.
• W2039452519 hasConcept C142724271 @default.
• W2039452519 hasConcept C143998085 @default.
• W2039452519 hasConcept C502942594 @default.
• W2039452519 hasConcept C530470458 @default.
• W2039452519 hasConcept C62478195 @default.
• W2039452519 hasConcept C71924100 @default.
• W2039452519 hasConcept C75217442 @default.
• W2039452519 hasConcept C86803240 @default.
• W2039452519 hasConcept C95444343 @default.
• W2039452519 hasConceptScore W2039452519C121608353 @default.
• W2039452519 hasConceptScore W2039452519C126322002 @default.
• W2039452519 hasConceptScore W2039452519C142724271 @default.
• W2039452519 hasConceptScore W2039452519C143998085 @default.
• W2039452519 hasConceptScore W2039452519C502942594 @default.
• W2039452519 hasConceptScore W2039452519C530470458 @default.
• W2039452519 hasConceptScore W2039452519C62478195 @default.
• W2039452519 hasConceptScore W2039452519C71924100 @default.
• W2039452519 hasConceptScore W2039452519C75217442 @default.
• W2039452519 hasConceptScore W2039452519C86803240 @default.
• W2039452519 hasConceptScore W2039452519C95444343 @default.
• W2039452519 hasIssue "1" @default.
• W2039452519 hasLocation W20394525191 @default.
• W2039452519 hasLocation W20394525192 @default.
• W2039452519 hasLocation W20394525193 @default.
• W2039452519 hasLocation W20394525194 @default.
• W2039452519 hasOpenAccess W2039452519 @default.
• W2039452519 hasPrimaryLocation W20394525191 @default.
• W2039452519 hasRelatedWork W1548146698 @default.
• W2039452519 hasRelatedWork W2058169199 @default.
• W2039452519 hasRelatedWork W2089776732 @default.
• W2039452519 hasRelatedWork W2350049866 @default.
• W2039452519 hasRelatedWork W2507518506 @default.
• W2039452519 hasRelatedWork W2557359331 @default.
• W2039452519 hasRelatedWork W2751784270 @default.
• W2039452519 hasRelatedWork W2892677547 @default.
• W2039452519 hasRelatedWork W2909515857 @default.

• next