FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039453075> ?p ?o ?g. }

• W2039453075 endingPage "112" @default.
• W2039453075 startingPage "109" @default.
• W2039453075 abstract "Brother of the regulator of imprinted sites (BORIS) is an epigenetically acting transcription factor which represses the tumor inhibitor functions of the tumor suppressor protein CTCF. BORIS expression has not been documented in adult females, making it an exciting molecular target for drug development in breast cancer. Previously, we demonstrated that vaccination of mice with zing-finger (ZF)-deleted non-functional BORIS results in regression of breast cancer and generation of potent anti-tumor immune responses. RNAi induction can be used as an alternative approach for selective tumor cell killing. Short interfering RNA (siRNA) molecules targeting BORIS were generated and their efficacy was tested in MDA-MB-231 breast cancer and non-malignant epithelial cell lines. Treatment with BORIS-specific siRNA, but not control siRNA led to a concentration-dependent reduction in BORIS expression and proportional apoptotic death of the cancer but not control cells. To our knowledge this is first report demonstrating a critical role of BORIS in maintaining tumor cell viability." @default.
• W2039453075 created "2016-06-24" @default.
• W2039453075 creator A5003489337 @default.
• W2039453075 creator A5004840287 @default.
• W2039453075 creator A5007628731 @default.
• W2039453075 creator A5020747559 @default.
• W2039453075 creator A5021809579 @default.
• W2039453075 creator A5024801252 @default.
• W2039453075 creator A5026025373 @default.
• W2039453075 creator A5030925921 @default.
• W2039453075 date "2008-05-01" @default.
• W2039453075 modified "2023-10-05" @default.
• W2039453075 title "Selective apoptosis of breast cancer cells by siRNA targeting of BORIS" @default.
• W2039453075 cites W1966933011 @default.
• W2039453075 cites W1982688267 @default.
• W2039453075 cites W2003170155 @default.
• W2039453075 cites W2006061308 @default.
• W2039453075 cites W2014713727 @default.
• W2039453075 cites W2017955991 @default.
• W2039453075 cites W2035357407 @default.
• W2039453075 cites W2042897749 @default.
• W2039453075 cites W2056890186 @default.
• W2039453075 cites W2083414728 @default.
• W2039453075 cites W2108132333 @default.
• W2039453075 cites W2135363218 @default.
• W2039453075 cites W2140936832 @default.
• W2039453075 cites W2148119803 @default.
• W2039453075 cites W2150365018 @default.
• W2039453075 cites W2164047860 @default.
• W2039453075 doi "https://doi.org/10.1016/j.bbrc.2008.03.040" @default.
• W2039453075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18355444" @default.
• W2039453075 hasPublicationYear "2008" @default.
• W2039453075 type Work @default.
• W2039453075 sameAs 2039453075 @default.
• W2039453075 citedByCount "49" @default.
• W2039453075 countsByYear W20394530752012 @default.
• W2039453075 countsByYear W20394530752013 @default.
• W2039453075 countsByYear W20394530752014 @default.
• W2039453075 countsByYear W20394530752015 @default.
• W2039453075 countsByYear W20394530752016 @default.
• W2039453075 countsByYear W20394530752017 @default.
• W2039453075 countsByYear W20394530752018 @default.
• W2039453075 countsByYear W20394530752019 @default.
• W2039453075 countsByYear W20394530752020 @default.
• W2039453075 countsByYear W20394530752021 @default.
• W2039453075 countsByYear W20394530752022 @default.
• W2039453075 countsByYear W20394530752023 @default.
• W2039453075 crossrefType "journal-article" @default.
• W2039453075 hasAuthorship W2039453075A5003489337 @default.
• W2039453075 hasAuthorship W2039453075A5004840287 @default.
• W2039453075 hasAuthorship W2039453075A5007628731 @default.
• W2039453075 hasAuthorship W2039453075A5020747559 @default.
• W2039453075 hasAuthorship W2039453075A5021809579 @default.
• W2039453075 hasAuthorship W2039453075A5024801252 @default.
• W2039453075 hasAuthorship W2039453075A5026025373 @default.
• W2039453075 hasAuthorship W2039453075A5030925921 @default.
• W2039453075 hasConcept C104317684 @default.
• W2039453075 hasConcept C121608353 @default.
• W2039453075 hasConcept C153911025 @default.
• W2039453075 hasConcept C166703698 @default.
• W2039453075 hasConcept C179185449 @default.
• W2039453075 hasConcept C190283241 @default.
• W2039453075 hasConcept C22615655 @default.
• W2039453075 hasConcept C502942594 @default.
• W2039453075 hasConcept C530470458 @default.
• W2039453075 hasConcept C54355233 @default.
• W2039453075 hasConcept C67705224 @default.
• W2039453075 hasConcept C86339819 @default.
• W2039453075 hasConcept C86803240 @default.
• W2039453075 hasConcept C96232424 @default.
• W2039453075 hasConceptScore W2039453075C104317684 @default.
• W2039453075 hasConceptScore W2039453075C121608353 @default.
• W2039453075 hasConceptScore W2039453075C153911025 @default.
• W2039453075 hasConceptScore W2039453075C166703698 @default.
• W2039453075 hasConceptScore W2039453075C179185449 @default.
• W2039453075 hasConceptScore W2039453075C190283241 @default.
• W2039453075 hasConceptScore W2039453075C22615655 @default.
• W2039453075 hasConceptScore W2039453075C502942594 @default.
• W2039453075 hasConceptScore W2039453075C530470458 @default.
• W2039453075 hasConceptScore W2039453075C54355233 @default.
• W2039453075 hasConceptScore W2039453075C67705224 @default.
• W2039453075 hasConceptScore W2039453075C86339819 @default.
• W2039453075 hasConceptScore W2039453075C86803240 @default.
• W2039453075 hasConceptScore W2039453075C96232424 @default.
• W2039453075 hasIssue "1" @default.
• W2039453075 hasLocation W20394530751 @default.
• W2039453075 hasLocation W20394530752 @default.
• W2039453075 hasOpenAccess W2039453075 @default.
• W2039453075 hasPrimaryLocation W20394530751 @default.
• W2039453075 hasRelatedWork W1572871015 @default.
• W2039453075 hasRelatedWork W1976394015 @default.
• W2039453075 hasRelatedWork W1998876971 @default.
• W2039453075 hasRelatedWork W2024030923 @default.
• W2039453075 hasRelatedWork W2030262874 @default.
• W2039453075 hasRelatedWork W2047147668 @default.
• W2039453075 hasRelatedWork W2130501958 @default.
• W2039453075 hasRelatedWork W2387630553 @default.
• W2039453075 hasRelatedWork W2411232599 @default.

• next