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• W2039454408 abstract "<b><i>Background/Aims:</i></b> The study was conducted to assess the influence of <i>CYP2C19 </i>polymorphisms on clopidogrel response variability and recurrent cardiovascular (CV) events in Chinese patients undergoing percutaneous coronary intervention (PCI). <b><i>Methods:</i></b> Platelet aggregation induced by 5 and 20 µmol/l adenosine diphosphate was measured in 109 patients at baseline, 12 h and 36 h after loading with 300 mg of clopidogrel. The primary end point was recurrent CV events, and the follow-up was scheduled at 1, 3, 6 and 12 months after PCI. The polymorphisms of <i>CYP2C19*2</i> and <i>CYP2C19*3 </i>were genotyped by DNA sequencing analysis<i>. </i><b><i>Results:</i></b> The maximal aggregation rates and inhibition of platelet aggregation among <i>CYP2C19*1/*1</i>, <i>CYP2C19*1/*2 </i>or <i>*3 </i>and <i>CYP2C19*2/*2 </i>or <i>*3 </i>genotypes were significantly different at 12 and 36 h after clopidogrel loading dose administration. Multiple linear regression analysis demonstrated that <i>CYP2C19*2</i> and <i>CYP2C19*3</i> might be predictors of clopidogrel response variability. During the 12-month follow-up, recurrent CV events occurred in 21 (19.63%) patients, and there were 5 (6.47%) deaths, 3 (2.80%) cases of ischemic stroke and 14 (13.1%) cases of acute coronary syndrome. Carriers of at least one <i>CYP2C19 </i>loss-of-function allele (<i>*1/*2 </i>or <i>*3, *2/*2 </i>or <i>*3</i>) incurred a 3.65-fold increase (95% CI 1.07–12.38; p = 0.038) in the risk of recurrent CV events 1 year after PCI compared to noncarriers (<i>*1/*1</i>). <b><i>Conclusion:</i></b> Polymorphisms in <i>CYP2C19*2 </i>and <i>CYP2C19*3 </i>contribute to variabilities in clopidogrel responsiveness. Patients carrying at least one <i>CYP2C19 </i>loss-of-function allele (<i>CYP2C19*2, *3</i>) are associated with an increased risk of recurrent CV events undergoing PCI." @default.
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• W2039454408 date "2013-01-01" @default.
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• W2039454408 title "Relationship of <b><i>CYP2C19*2 </i></b>and <b><i>CYP2C19*3 </i></b>Gene Polymorphism with Clopidogrel Response Variability and Recurrent Cardiovascular Events in Chinese Patients Undergoing Percutaneous Coronary Intervention" @default.
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• W2039454408 doi "https://doi.org/10.1159/000346736" @default.
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