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• W2039472011 abstract "BackgroundMeasles infection requires 2 cellular receptors, signaling lymphocyte activation molecule (SLAM) and CD46. Known and novel single nucleotide polymorphisms (SNPs) in SLAM and CD46 genes might influence the immune response to measles vaccine.ObjectiveWe sought to identify SNP associations in SLAM and CD46 genes with variations in measles antibody response.MethodsWe genotyped known SNPs in SLAM and CD46 genes in 339 subjects vaccinated with 2 doses of measles-mumps-rubella vaccine. We also sequenced the measles virus–binding domains of SLAM and CD46 to identify novel SNPs.ResultsIncreased representation of minor alleles for rs3796504 and rs164288 in the SLAM gene was associated with an allele dose-related decrease (4-fold) in measles-specific antibodies. Heterozygous genotype TC for rs12076998 located in the untranslated region 33 bp upstream of the measles virus–binding domain of the SLAM gene was associated with higher median antibody levels (1991 vs 1467 IU/L, P = .01) compared with wild-type TT. Within the CD46 gene, the minor allele C for intronic SNP (rs11118580) was associated with an allele dose-related decrease in measles antibodies (1072 vs 1795 IU/L, P < .01). Decreases in minor allele counts for rs3796504, rs164288, and rs1118580 demonstrated a significant (P < .001) additive effect on measles-specific antibodies.ConclusionOur data suggest that specific SNPs present in both the SLAM and CD46 genes are associated with measurable and significant variations in antibody response after measles vaccination.Clinical implicationsUnderstanding the immunogenetics of measles vaccine receptors is important to better understand variations in immune responses to vaccines and to design better vaccines. Measles infection requires 2 cellular receptors, signaling lymphocyte activation molecule (SLAM) and CD46. Known and novel single nucleotide polymorphisms (SNPs) in SLAM and CD46 genes might influence the immune response to measles vaccine. We sought to identify SNP associations in SLAM and CD46 genes with variations in measles antibody response. We genotyped known SNPs in SLAM and CD46 genes in 339 subjects vaccinated with 2 doses of measles-mumps-rubella vaccine. We also sequenced the measles virus–binding domains of SLAM and CD46 to identify novel SNPs. Increased representation of minor alleles for rs3796504 and rs164288 in the SLAM gene was associated with an allele dose-related decrease (4-fold) in measles-specific antibodies. Heterozygous genotype TC for rs12076998 located in the untranslated region 33 bp upstream of the measles virus–binding domain of the SLAM gene was associated with higher median antibody levels (1991 vs 1467 IU/L, P = .01) compared with wild-type TT. Within the CD46 gene, the minor allele C for intronic SNP (rs11118580) was associated with an allele dose-related decrease in measles antibodies (1072 vs 1795 IU/L, P < .01). Decreases in minor allele counts for rs3796504, rs164288, and rs1118580 demonstrated a significant (P < .001) additive effect on measles-specific antibodies. Our data suggest that specific SNPs present in both the SLAM and CD46 genes are associated with measurable and significant variations in antibody response after measles vaccination." @default.
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• W2039472011 date "2007-09-01" @default.
• W2039472011 modified "2023-10-08" @default.
• W2039472011 title "Variations in measles vaccine–specific humoral immunity by polymorphisms in SLAM and CD46 measles virus receptors" @default.
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• W2039472011 cites W1969430072 @default.
• W2039472011 cites W1976525356 @default.
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• W2039472011 cites W2015778158 @default.
• W2039472011 cites W2020350871 @default.
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• W2039472011 cites W2021056514 @default.
• W2039472011 cites W2023101811 @default.
• W2039472011 cites W2029476533 @default.
• W2039472011 cites W2031591176 @default.
• W2039472011 cites W2032410704 @default.
• W2039472011 cites W2033958700 @default.
• W2039472011 cites W2035038803 @default.
• W2039472011 cites W2035650947 @default.
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• W2039472011 doi "https://doi.org/10.1016/j.jaci.2007.04.036" @default.
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